Risk and safety requirements for diagnostic and therapeutic procedures in allergology: World Allergy Organization Statement

World Allergy Organization Journal - Tập 9 - Trang 33 - 2016
Marek L. Kowalski1, Ignacio J. Ansotegui2, Werner Aberer3, Mona Al‐Ahmad4, Mübeccel Akdiş5, Barbara Ballmer‐Weber6, Kirsten Beyer7, Miguel Blanca8, Simon G A Brown9, Chaweewan Bunnag10, Arnaldo Capriles Hulett11, Mariana Castells12, Hiok Hee Chng13, F. De Blay14, Motohiro Ebisawa15, Stanley Fineman16, David B.K. Golden17, Tari Haahtela18, Michael Kaliner19, Connie Katelaris20, Bee Wah Lee21, Joanna Makowska22, Ulrich Müller23, Joaquim Mullol24, John Oppenheimer25, Hae‐Sim Park26, James Parkerson27, Giovanni Passalacqua28, Ruby Pawankar29, Harald Renz30, Franziska Ruëff31, Mario Sánchez‐Borges32, Joaquı́n Sastre33, Glenis Scadding34, Scott H. Sicherer35, Pongsakorn Tantilipikorn10, James M. Tracy36, Vera Van Kempen37, Barbara Bohle38, Giorgio Walter Canonica39, Luis Caraballo40, Maximiliano Gómez41, Komei Ito42, Erika Jensen‐Jarolim43, Mark Larché44, Giovanni Melioli45, Lars K. Poulsen46, Rudolf Valenta47, Torsten Zuberbier48
1Department of Immunology, Rheumatology & Allergy, Medical University of Lodz, 251 Pomorska Str, 92-213 Lodz, Poland.
2Department of Allergy and Immunology, Hospital Quiron Bizkaia, Bilbao, Spain.
3Department of Dermatology, Medical University of Graz, Graz, Austria
4Microbiology Department, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
5Swiss institute of Allergy & Asthma research, Davos, Switzerland.
6Allergy Unit, Dermatology Clinic, University Hospital Zürich, University Zürich, Zürich, Switzerland.
7Kirsten Beyer, Charité Universitätsmedizin Berlin, Klinik für Pädiatrie m.S. Pneumologie und Immunologie, Berlin, Germany.
8Hospital Reg. Univ. Carlos Haya, Allergy Serv, Malaga, Spain.
9Royal Perth Hospital, Department of Emergency Medicine, Perth, WA, Australia.
10Department of Otolaryngology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
11Allergology Unit, Hospital San Juan de Dios, Caracas, Venezuela.
12Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA.
13Department of Rheumatology, Allergy & Immunology, Tan Tock Seng Hospital, Singapore, Singapore.
14Hôpitaux Universitaires de Strasbourg, Chest Diseases Department, Strasbourg, France.
15Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan.
16Emory University School of Medicine, Atlanta Allergy & Asthma, Atlanta, Georgia.
17Johns Hopkins University, Baltimore, Md., USA
18Helsinki University Central Hospital, Helsinki, Finland.
19Institute for Asthma & Allergy, Bethesda, MD, USA.
20Westmead Medical Centre, Westmead, NSW, Australia.
21Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
22CSK, Department of Allergy & Clinical Immunology, Lodz, Poland.
23Spitalnetz, Bern, Switzerland.
24Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, and CIBERES, Barcelona, Spain.
25UMDNJ – Rutgers Medical School, c/o Pulmonary and Allergy Associates, Summit, New Jersey, USA.
26Department of Internal Medicine, Ajou University School of Medicine, Suwon, South Korea
27University of South Florida, Tampa, FL USA
28Allergy and Respiratory Diseases, IRCCS San Martino Hospital IST, University of Genoa, Genoa, Italy.
29Department of Pediatrics, Nippon Medical School, Tokyo, Japan
30Universitatsklinikum GI & MR GmbH, Institut fur Laboratoriumsmedizin & Path, Standort Marburg, Marburg, Germany.
31Klinikum der Ludwig-Maximilians-Universitat, Klinik & Poliklinik fur Dermatologie & Allergologie, Munchen, Germany.
32Allergy and Clinical Immunology Department, Centro Medico-Docente La Trinidadad, Caracas, Venezuela.
33Allergy Department, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, CIBER de Enfermedades Respiratorias (CIBERES), Institute Carlos III, Madrid, Spain.
34RNTNE Hospital, London, UK.
35Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
36University of Nebraska, Omaha, NE, USA.
37Institute for Prevention and Occupational Medicine, German Social Accident Insurance, Ruhr-University Bochum (IPA), Bochum, Germany.
38Division of Experimental Allergology, Department of Pathophysiology, Allergy Research Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria.
39Allergy & Respiratory Disease Clinic, DIMI – Department Int Med, University of Genoa, IRCCS AOU, San Martino – IST, Genoa, Italy.
40Immunology Department, Universidad De Cartagena, Cartagena, Colombia.
41Hospital San Bernardo, Salta, Argentina
42Department of Allergy, Aichi Children's Health and Medical Center, Aichi, Japan
43Messerli Research Institute, Medical University Vienna, University Vienna, Vienna, Austria.
44Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada
45Istituto Giannina Gaslini, Genoa, Italy
46Gentofte University Hospital, Lab for Allergology, Allergy Clinic, Hellerup, Denmark.
47Department of Pathophysiology, AKH, Wien, Austria.
48Campus Charite Mitte, Klinik fur Dermatologie & Allergologie, Berlin, Germany.

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Pepys, 1975, Skin testing, Br J Hosp Med (Lond), 14, 412

Piette, 2002, Prick tests to aeroallergens: is it possible simply to wipe the device between tests?, Allergy, 57, 940, 10.1034/j.1398-9995.2002.23536.x

Masse, 2011, Comparison of five techniques of skin prick tests used routinely in Europe, Allergy, 66, 1415, 10.1111/j.1398-9995.2011.02679.x

Brown, 1979, The relationship of respiratory allergy, skin test reactivity, and serum IgE in a community population sample, J Allergy Clin Immunol, 63, 328, 10.1016/0091-6749(79)90127-1

Nelson, 1993, Comparative performance of five commercial prick skin test devices, J Allergy Clin Immunol, 92, 750, 10.1016/0091-6749(93)90019-C

Oppenheimer, 2006, Skin testing, Ann Allergy Asthma Immunol, 96, S6, 10.1016/S1081-1206(10)60895-2

Bock, 1977, Proper use of skin tests with food extracts in diagnosis of hypersensitivity to food in children, Clin Allergy, 7, 375, 10.1111/j.1365-2222.1977.tb01466.x

Skassa-Brociek, 1987, Skin test reactivity to histamine from infancy to old age, J Allergy Clin Immunol, 80, 711, 10.1016/0091-6749(87)90292-2

Australasian Society of Clinical Immunology and Allergy. Skin Prick Testing for the diagnosis of allergic diseases – A Manual for Practitioners [http://www.allergy.org.au/health-professionals/papers/skin-prick-testing], 2006, Revised May 2013.

Liccardi, 2006, Systemic reactions from skin testing: literature review, J Investig Allergol Clin Immunol, 16, 75

Lockey, 1987, Fatalities from immunotherapy (IT) and skin testing (ST), J Allergy Clin Immunol, 79, 660, 10.1016/S0091-6749(87)80164-1

Bernstein, 2004, Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001, J Allergy Clin Immunol, 113, 1129, 10.1016/j.jaci.2004.02.006

Norrman, 2009, Adverse reactions to skin prick testing in children - prevalence and possible risk factors, Pediatr Allergy Immunol, 20, 273, 10.1111/j.1399-3038.2008.00761.x

Turkeltaub, 1989, The risk of adverse reactions from percutaneous prick-puncture allergen skin testing, venipuncture, and body measurements: data from the second National Health and Nutrition Examination Survey 1976-80 (NHANES II), J Allergy Clin Immunol, 84, 886, 10.1016/0091-6749(89)90384-9

Valyasevi, 1999, Systemic reactions to allergy skin tests, Ann Allergy Asthma Immunol, 83, 132, 10.1016/S1081-1206(10)62624-5

Swender, 2012, The rate of epinephrine administration associated with allergy skin testing in a suburban allergy practice from 1997 to 2010, Allergy Rhinol (Providence), 3, e55, 10.2500/ar.2012.3.0034

Devenney, 2000, Skin prick tests may give generalized allergic reactions in infants, Ann Allergy Asthma Immunol, 85, 457, 10.1016/S1081-1206(10)62571-9

Bernstein, 2008, Allergy diagnostic testing: an updated practice parameter, Ann Allergy Asthma Immunol, 100, S1

Bousquet, 2012, Practical guide to skin prick tests in allergy to aeroallergens, Allergy, 67, 18, 10.1111/j.1398-9995.2011.02728.x

Lockey, 1989, The Hymenoptera venom study II. Skin test results and safety of venom skin testing, J Allergy Clin Immunol, 84, 967, 10.1016/0091-6749(89)90396-5

Strohmeier, 2013, Simultaneous intradermal testing with Hymenoptera venoms is safe and more efficient than sequential testing, Allergy, 68, 542, 10.1111/all.12123

Yocum, 1996, Safety and efficacy of an accelerated method for venom skin testing, J Allergy Clin Immunol, 97, 1424, 10.1016/S0091-6749(96)70217-8

Golden, 2011, Stinging insect hypersensitivity: A practice parameter update 2011, J Allergy Clin Immunol, 127, 852, 10.1016/j.jaci.2011.01.025

Cox, 2008, Pearls and pitfalls of allergy diagnostic testing: report from the American College of Allergy Asthma and Immunology/American Academy of Allergy Asthma and Immunology Specific IgE Test Task Force, Ann Allergy Asthma Immunol, 101, 580, 10.1016/S1081-1206(10)60220-7

Kränke, 2009, Skin testing for IgE-mediated drug allergy, Immunol Allergy Clin N Am, 29, 503, 10.1016/j.iac.2009.04.003

Barbaud, 2009, Skin testing in delayed reactions to drugs, Immunol Allergy Clin N Am, 29, 517, 10.1016/j.iac.2009.04.010

Romano, 2002, Diagnosing nonimmediate reactions to penicillins by in vivo tests, Int Arch Allergy Immunol, 129, 169, 10.1159/000065876

Brockow, 2013, Skin test concentrations for systemically administered drugs – an ENDA/EAACI Drug Allergy Interest Group position paper, Allergy, 68, 702, 10.1111/all.12142

Barbaud, 1998, The use of skin testing in the investigation of cutaneous adverse drug reactions, Br J Dermatol, 139, 49, 10.1046/j.1365-2133.1998.02313.x

Romano, 2008, Patch testing in non-immediate drug eruptions, Allergy, Asthma and Clin Immunol, 4, 66, 10.1186/1710-1492-4-2-66

Rive, 2013, Testing for drug hypersensitivity syndromes, Clin Biochem Rev, 34, 15

Brockow, 2002, General considerations for skin test procedures in the diagnosis of drug hypersensitivity, Allergy, 57, 45

Barbaud, 2001, Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drug reactions, Contact Dermatitis, 45, 321, 10.1034/j.1600-0536.2001.450601.x

Alanko, 1993, Patch testing in cutaneous reactions caused by carbamazepine, Contact Dermatitis, 29, 254, 10.1111/j.1600-0536.1993.tb03560.x

Barbaud, 2004, Drug skin tests in cutaneous adverse drug reactions to pristinamycin: 29 cases with a study of cross-reactions between synergistins, Contact Dermatitis., 50, 22, 10.1111/j.0105-1873.2004.00280.x

Mashiah, 2003, A systemic reaction to patch testing for the evaluation of acute generalized exanthematous pustulosis, Arch Dermatol, 139, 1181, 10.1001/archderm.139.9.1181

van Kampen, 2000, Occupational airway sensitizers: an overview on the respective literature, Am J Ind Med., 38, 164, 10.1002/1097-0274(200008)38:2<164::AID-AJIM7>3.0.CO;2-2

Baur, 2014, Allergens causing occupational asthma: an evidence-based evaluation of the literature, Int Arch Occup Environ Health., 87, 339, 10.1007/s00420-013-0866-9

van Kampen, 2013, Evaluation of commercial skin prick test solutions for selected occupational allergens, Allergy, 68, 651, 10.1111/all.12116

Bergman, 1995, Contact urticaria with anaphylactic reactions caused by occupational exposure to iridium salt, Contact Dermatitis., 32, 14, 10.1111/j.1600-0536.1995.tb00833.x

Van Kampen, 2013, EAACI position paper: skin prick testing in the diagnosis of occupational type I allergies, Allergy., 68, 580, 10.1111/all.12120

Cabañes, 2012, SEAIC. Latex allergy: Position Paper, J Investig Allergol Clin Immunol., 22, 313

Chua, 2013, Prevalence of latex allergy in spina bifida patients in Singapore, Asia Pac Allergy., 3, 96, 10.5415/apallergy.2013.3.2.96

Kelly, 1993, Skin and serologic testing in the diagnosis of latex allergy, J Allergy Clin Immunol., 91, 1140, 10.1016/0091-6749(93)90316-8

Hamilton, 1998, Diagnosis of natural rubber latex allergy: multicenter latex skin testing efficacy study. Multicenter Latex Skin Testing Study Task Force, J Allergy Clin Immunol, 102, 482, 10.1016/S0091-6749(98)70139-3

Hamilton, 2002, Clinical and laboratory-based methods in the diagnosis of natural rubber latex allergy, J Allergy Clin Immunol, 110, S47, 10.1067/mai.2002.125334

Accetta Pedersen, 2012, Analysis of available diagnostic tests for latex sensitization in an at-risk population, Ann Allergy Asthma Immunol., 108, 94, 10.1016/j.anai.2011.11.009

Nettis, 2001, Systemic reactions on SPT to latex, Allergy., 56, 355, 10.1034/j.1398-9995.2001.00862.x

Ravensberg, 2007, Validated safety predictions of airway responses to house dust mite in asthma, Clin Exp Allergy, 37, 100, 10.1111/j.1365-2222.2006.02617.x

Taylor, 2000, Comparison of incremental and bolus dose inhaled allergen challenge in asthmatic subjects, Clin Exp Allergy, 30, 56, 10.1046/j.1365-2222.2000.00657.x

Moscato, 2012, EAACI consensus statement for investigation of work-related asthma in non-specialized centres, Allergy, 67, 491, 10.1111/j.1398-9995.2011.02784.x

Schulze, 2013, Bronchial allergen challenges in children - safety and predictors, Pediatr Allergy Immunol, 24, 19, 10.1111/pai.12031

Melillo G, Bonini S, Cocco O, Davies RJ, de Monchy GR, Frolund L, Pelikan Z. EAACI provocation tests with allergens. Report prepared by the European Academy of Allergology and Clinical Immunology Subcommittee on provocation tests with allergens. Allergy. 1997;52 (suppl.35):5-36.

Barnig, 2013, Nonallergic airway hyperresponsivenss and allergen-specific IgE levels are the main determinants of the early and late asthmatic response to allergen, J Investig Allergol Clin Immunol, 23, 267

Vandenplas, 2013, Incidence of severe asthmatic reactions after challenge exposure to occupational agents, Chest, 143, 1261, 10.1378/chest.12-1983

Bousquet, 2007, Safety conditions for allergic challenge tests realization, Rev Fr Allergol Immunol Clin, 47, 323

Kowalski, 2011, Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: review of the EAACI/ENDA and GA2LEN/HANNA, Allergy, 66, 818, 10.1111/j.1398-9995.2011.02557.x

Dahlén, 1998, Inhalation challenge in ASA-induced asthma, Respir Med, 92, 378, 10.1016/S0954-6111(98)90279-7

Melillo, 2001, Oral and inhalation provocation tests for the diagnosis of aspirin-induced asthma, Allergy, 56, 899, 10.1034/j.1398-9995.2001.00025.x

Nizankowska-Mogilnicka, 2007, EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity, Allergy, 62, 1111, 10.1111/j.1398-9995.2007.01409.x

Kowalski, 2013, Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs, Allergy, 68, 1219, 10.1111/all.12260

Hussein, 1989, The incidence of analgesics intolerance in asthmatic children detected by history and inhalation challenge with lysine acetylsalicylate, Klin Padiatr, 201, 1, 10.1055/s-2007-1025266

Melillo, 1993, Dosimeter inhalation test with lysine acetylsalicylate for the detection of aspirin-induced asthma, Ann Allergy, 71, 61

Park, 1995, Early and late onset asthmatic responses following lysine-aspirin inhalation in aspirin-sensitive asthmatic patients, Clin Exp Allergy, 25, 38, 10.1111/j.1365-2222.1995.tb01000.x

Nizankowska, 2000, Oral and bronchial provocation tests with aspirin for diagnosis of aspirin-induced asthma, Eur Respir J, 15, 863, 10.1034/j.1399-3003.2000.15e09.x

Makowska, 2008, Systemic responses after bronchial aspirin challenge in sensitive patients with asthma, J Allergy Clin Immunol, 121, 348, 10.1016/j.jaci.2007.09.039

Jang, 2000, Severe reaction to lysine aspirin, Allergy, 55, 1092, 10.1034/j.1398-9995.2000.00790.x

Phillips, 1989, Inhaled lysine-aspirin as a bronchoprovocation procedure in aspirin-sensitive asthma: its repeatability, absence of a late-phase reaction, and the role of histamine, J Allergy Clin Immunol, 84, 232, 10.1016/0091-6749(89)90330-8

Cockcroft, 2010, Direct challenge tests: Airway hyperresponsiveness in asthma: its measurement and clinical significance, Chest, 138, 18S, 10.1378/chest.10-0088

Anderson, 2010, Indirect challenge tests: Airway hyperresponsiveness in asthma: its measurement and clinical significance, Chest, 138, 25S, 10.1378/chest.10-0116

Parkerson, 2011, Mannitol as an indirect bronchoprovocation test for the 21st century, Ann Allergy Asthma Immunol, 106, 91, 10.1016/j.anai.2010.11.010

Cockcroft, 2006, Mechanisms of airway hyperresponsiveness, J Allergy Clin Immunol, 118, 551, 10.1016/j.jaci.2006.07.012

Sont, 1999, Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group, Am J Respir Crit Care Med, 159, 1043, 10.1164/ajrccm.159.4.9806052

Sastre, 2003, Need for monitoring nonspecific bronchial hyperresponsiveness before and after isocyanate inhalation challenge, Chest, 123, 1276, 10.1378/chest.123.4.1276

Schulze, 2012, Methacholine challenge in young children as evaluated by spirometry and impulse oscillometry, Respir Med, 106, 627, 10.1016/j.rmed.2012.01.007

Sterk, 1993, Eur Respir J Suppl, 16, 53, 10.1183/09041950.053s1693

Crapo, 2000, Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999, Am J Respir Crit Care Med, 161, 309, 10.1164/ajrccm.161.1.ats11-99

1997, Clinical exercise testing with reference to lung diseases: indications, standardization and interpretation strategies, Eur Respir J, 10, 2662, 10.1183/09031936.97.10112662

Pratter, 1993, Bronchodilator reversal of bronchospasm and symptoms incurred during methacholine bronchoprovocation challenge. Documentation of safety and time course, Chest, 104, 1342, 10.1378/chest.104.5.1342

Subbarao, 2005, Protection by budesonide and fluticasone on allergen-induced airway responses after discontinuation of therapy, J Allergy Clin Immunol, 115, 745, 10.1016/j.jaci.2004.11.023

Devillier, 2011, The allergen challenge chamber: a valuable tool for optimizing the clinical development of pollen immunotherapy, Allergy, 66, 163, 10.1111/j.1398-9995.2010.02473.x

Gosepath, 2005, Nasal provocation testing as an international standard for evaluation of allergic and nonallergic rhinitis, Laryngoscope, 115, 512, 10.1097/01.MLG.0000149682.56426.6B

Tantilipikorn, 2010, Nasal provocation test: how to maximize its clinical use?, Asian Pac J Allergy Immunol, 28, 225

Zerah-Lancer, 2009, Usefulness of nasal provocation tests in occupational rhinitis, Rhinology, 47, 432

Rondón, 2014, Follow-up study in local allergic rhinitis shows a consistent entity not evolving to systemic allergic rhinitis, J Allergy Clin Immunol, 133, 1026, 10.1016/j.jaci.2013.10.034

Pawankar, 2011, Burden of Disease: Rhinitis, Conjunctivitis, Rhinosinusitis, 27

Dordal, 2011, Allergen-specific nasal provocation testing: review by the rhinoconjunctivitis committee of the Spanish Society of Allergy and Clinical Immunology, J Investig Allergol Clin Immunol, 21, 1

Kanthawatana, 1997, Evaluation of threshold criteria for the nasal histamine challenge test in perennial allergic rhinitis, Asian Pac J Allergy Immunol, 15, 65

Rondon, 2010, Local allergic rhinitis: concept, clinical manifestations, and diagnostic approach, J Investig Allergol Clin Immunol, 20, 364

Tuskan, 2010, The value and safety of specific nasal provocation in the diagnosis of allergic rhinitis in mild persistent asthma under inhaled steroid therapy, Asian Pac J Allergy Immunol, 28, 115

Wojdas, 2005, Nasal provocative test in patients allergic to pollen, Ann Agric Environ Med, 12, 173

Passalacqua, 2013, Grading local side effects of sublingual immunotherapy for respiratory allergy: speaking the same language, J Allergy Clin Immunol, 132, 93, 10.1016/j.jaci.2013.03.039

Lee, 2010, Use of intranasal ketorolac and modified oral aspirin challenge for desensitization of aspirin-exacerbated respiratory disease, Ann Allergy Asthma Immunol, 105, 130, 10.1016/j.anai.2010.05.020

Miller, 2013, Nasal lysine aspirin challenge in the diagnosis of aspirin - exacerbated respiratory disease: asthma and rhinitis, Clin Exp Allergy, 43, 874, 10.1111/cea.12110

Makowska, 2015, Hypersensitivity to aspirin and other NSAIDs: Diagnostic approach in patients with chronic rhinosinusitis, Curr Allergy Asthma Rep, 15, 47, 10.1007/s11882-015-0552-y

Tichenor, 2008, Nasal and sinus endoscopy for medical management of resistant rhinosinusitis, including postsurgical patients, J Allergy Clin Immunol, 121, 917, 10.1016/j.jaci.2007.08.065

Van Spronsen, 2008, Evidence-based recommendations regarding the differential diagnosis and assessment of nasal congestion: using the new GRADE system, Allergy, 63, 820, 10.1111/j.1398-9995.2008.01729.x

Amine, 2013, Outcomes of endoscopy and computed tomography in patients with chronic rhinosinusitis, Int Forum Allergy Rhinol, 3, 73, 10.1002/alr.21071

Fokkens, 2012, European Position Paper on Rhinosinusitis and Nasal Polyps 2012, Rhinology, 50, 1

Alobid, 2014, Oral plus nasal corticosteroids improve smell, nasal congestion, and inflammation in sino-nasal polyposis, Laryngoscope, 124, 50, 10.1002/lary.24330

Berger, 2011, The contribution of flexible endoscopy for diagnosis of acute bacterial rhinosinusitis, Eur Arch Otorhinolaryngol, 268, 235, 10.1007/s00405-010-1329-5

Marseglia, 2007, The 10-day mark is a good way to diagnose not only acute rhinosinusitis but also adenoiditis, as confirmed by endoscopy, Int J Pediatr Otorhinolaryngol, 71, 581, 10.1016/j.ijporl.2006.12.003

Meltzer, 2004, Rhinosinusitis: establishing definitions for clinical research and patient care, J Allergy Clin Immunol, 114, 155, 10.1016/j.jaci.2004.09.029

Hellings, 2012, Executive summary of European Task Force document on diagnostic tools in rhinology, Rhinology, 50, 339, 10.4193/Rhino11.252

Nowak-Wegrzyn, 2009, Work Group report: oral food challenge testing, J Allergy Clin Immunol, 123, S365, 10.1016/j.jaci.2009.03.042

Bock, 1988, Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual, J Allergy Clin Immunol, 82, 986, 10.1016/0091-6749(88)90135-2

Sampson, 2012, Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report, J Allergy Clin Immunol, 130, 1260, 10.1016/j.jaci.2012.10.017

Ahrens, 2014, Positive reactions to placebo in children undergoing double-blind, placebo-controlled food challenge, Clin Exp Allergy, 44, 572, 10.1111/cea.12284

Sicherer, 1999, Food allergy: when and how to perform oral food challenges, Pediatr Allergy Immunol, 10, 226, 10.1034/j.1399-3038.1999.00040.x

Bindslev-Jensen, 2004, Standardization of food challenges in patients with immediate reactions to foods-position paper from the European Academy of Allergology and Clinical Immunology, Allergy, 59, 690, 10.1111/j.1398-9995.2004.00466.x

Liebermann, 2011, Outcomes of office-based. Open food challenges in the management of food allergy, J Allergy Clin Immunol, 128, 1120, 10.1016/j.jaci.2011.07.012

Untersmayr, 2008, The role of protein digestibility and antacids on food allergy outcomes, J Allergy Clin Immunol, 121, 1301, 10.1016/j.jaci.2008.04.025

Boyce, 2010, Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel, J Allergy Clin Immunol, 126, S1

Rancé, 2009, Oral food challenge in children: an expert review, Eur Ann Allergy Clin Immunol, 41, 35

Fleischer, 2011, Oral food challenges in children with a diagnosis of food allergy, J Pediatr, 158, 578, 10.1016/j.jpeds.2010.09.027

Bock, 2007, Further fatalities caused by anaphylactic reactions to food, 2001-2006, J Allergy Clin Immunol, 119, 1016, 10.1016/j.jaci.2006.12.622

Cianferoni, 2013, Oral food challenge to wheat: a near-fatal anaphylaxis and review of 93 food challenges in children, World Allergy Organ J, 6, 14, 10.1186/1939-4551-6-14

Perry, 2004, Risk of oral food challenges, J Allergy Clin Immunol, 114, 1164, 10.1016/j.jaci.2004.07.063

Sicherer, 2000, Dose-response in double-blind, placebo-controlled oral food challenges in children with atopic dermatitis, J Allergy Clin Immunol, 105, 582, 10.1067/mai.2000.104941

Järvinen, 2009, Epinephrine treatment is infrequent and biphasic reactions are rare in food-induced reactions during oral food challenges in children, J Allergy Clin Immunol, 124, 1267, 10.1016/j.jaci.2009.10.006

Rolinck-Werninghaus, 2012, Outcome of oral food challenges in children in relation to symptom-eliciting allergen dose and allergen-specific IgE, Allergy, 67, 951, 10.1111/j.1398-9995.2012.02838.x

Peters, 2012, The predictive value of skin prick testing for challenge-proven food allergy: a systematic review, Pediatr Allergy Immunol, 23, 347, 10.1111/j.1399-3038.2011.01237.x

Ahrens, 2012, Organ-specific symptoms during oral food challenge in children with food allergy, J Allergy Clin Immunol, 130, 549, 10.1016/j.jaci.2012.05.045

Calvani, 2012, Oral food challenge: safety, adherence to guidelines and predictive value of skin prick testing, Pediatr Allergy Immunol, 23, 755, 10.1111/pai.12016

Niggemann, 2012, Accurate oral food challenge requires a cumulative dose on a subsequent day, J Allergy Clin Immunol, 130, 261, 10.1016/j.jaci.2012.03.021

Sampson, 2011, A phase II, randomized, double blind, parallel group, placebo controlled oral food challenge trial of Xolair (omalizumab) in peanut allergy, J Allergy Clin Immunol, 127, 1309, 10.1016/j.jaci.2011.01.051

Leonard, 2011, Food protein-induced enterocolitis syndrome: an update on natural history and review of management, Ann Allergy Asthma Immunol, 107, 95, 10.1016/j.anai.2011.06.004

Aberer, 2003, European Network for Drug Allergy (ENDA); EAACI interest group on drug hypersensitivity: Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations, Allergy, 58, 854, 10.1034/j.1398-9995.2003.00279.x

Messaad, 2004, Drug provocation tests in patients with a history suggesting an immediate drug hypersensitivity reaction, Ann Intern Med, 140, 1001, 10.7326/0003-4819-140-12-200406150-00009

Aberer, 2009, Provocation tests in drug hypersensitivity, Immunol Allergy Clin North Am, 29, 567, 10.1016/j.iac.2009.04.008

Torres, 2003, Diagnosis of immediate allergic reactions to beta-lactam antibiotics, Allergy, 58, 961, 10.1034/j.1398-9995.2003.00280.x

Romano, 2004, ENDA; EAACI: Diagnosis of non-immediate reactions to betalactamantibiotics, Allergy, 59, 1153, 10.1111/j.1398-9995.2004.00678.x

Blanca, 2009, Update on the evaluation of hypersensitivity reactions to beta-lactams, Allergy, 64, 183, 10.1111/j.1398-9995.2008.01924.x

Torres, 2012, Diagnostic evaluation of patients with non-immediate cutaneous hypersensitivity reactions to iodinated contrast media, Allergy, 67, 929, 10.1111/j.1398-9995.2012.02840.x

Macy, 2007, Aspirin challenge and desensitization for aspirin-exacerbated respiratory disease: a practice paper, Ann Allergy Asthma Immunol, 98, 172, 10.1016/S1081-1206(10)60692-8

Mirakian, 2009, BSACI: BSACI guidelines for the management of drug allergy, Clin Exp Allergy, 39, 43, 10.1111/j.1365-2222.2008.03155.x

2010, Drug allergy: an updated practice parameter, Ann Allergy Asthma Immunol, 105, 259, 10.1016/j.anai.2010.08.002

du Toit, 2011, The RCPCH care pathway for children with drug allergies: an evidence and consensus basednational approach, Arch Dis Child, 96, i15, 10.1136/archdischild-2011-300116

Po, 2001, Causality assessment of adverse effects: when is re-challenge ethically acceptable?, Drug Saf, 24, 793, 10.2165/00002018-200124110-00001

Romano, 1999, A diagnostic protocol for evaluationg nonimmediate reactions to aminopenicillins, J Allergy Clin Immunol, 103, 1186, 10.1016/S0091-6749(99)70197-1

Toogood, 1988, Risk of anaphylaxis in patients receiving b-blocker drugs, J Allergy Clin Immunol, 81, 1, 10.1016/0091-6749(88)90212-6

Drain, 2001, Preventing and managing drug-induced anaphylaxis, Drug Saf, 24, 843, 10.2165/00002018-200124110-00005

Bernstein, 1999, Ann Allergy Asthma Immunol, 83, 665, 10.1016/S1081-1206(10)62890-6

Ruëff, 1996, The sting challenge test in Hymenoptera venom allergy. Position paper of the Subcommittee on Insect Venom Allergy of the European Academy of Allergology and Clinical Immunology, Allergy, 51, 216

Hunt, 1978, A controlled trial of immunotherapy in insect hypersensitivity, N Engl J Med, 299, 157, 10.1056/NEJM197807272990401

Franken, 1994, Lack of reproducibility of a single negative sting challenge response in the assessment of anaphylactic risk in patients with suspected yellow jacket hypersensitivity, J Allergy Clin Immunol, 93, 431, 10.1016/0091-6749(94)90351-4

Koschel, 2014, Tolerated sting challenge in patients on Hymenoptera venom immunotherapy improves health-related quality of life, J Investig Allergol Clin Immunol., 24, 226

Müller, 1992, Immunotherapy with honeybee venom and yellow jacket venom is different regarding efficacy and safety, J Allergy Clin Immunol, 89, 529, 10.1016/0091-6749(92)90319-W

Haeberli, 2003, Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy, Clin Exp Allergy, 33, 1216, 10.1046/j.1365-2222.2003.01755.x

Ruëff, 2013, Clinical effectiveness of Hymenoptera venom immunotherapy. A prospective observational multicenter study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity, PlosONE, 8, e63233, 10.1371/journal.pone.0063233

Ruëff, 2014, Predictors of clinical effectiveness of Hymenoptera venom immunotherapy, Clin Exp Allergy, 44, 736, 10.1111/cea.12275

Bonaparte, 2011, A double-blind randomised controlled trial assessing the efficacy of topical lidocaine in extended flexible endoscopic nasal examinations, Clin Otolaryngol, 36, 550, 10.1111/j.1749-4486.2011.02403.x

Urisu, 2011, Japanese guideline for food allergy, Allergol Int, 60, 221, 10.2332/allergolint.11-RAI-0329

Golden, 1981, Dose dependence of Hymenoptera venom immunotherapy, J Allergy Clin Immunol, 67, 370, 10.1016/0091-6749(81)90082-8

Bousquet, 1988, Systemic reactions during maintenance immunotherapy with honey bee venom, Ann Allergy, 61, 63

Ruëff, 2001, Patients still reacting to a sting challenge while receiving Hymenoptera venom immunotherapy are protected by increased venom doses, J Allergy and Clin Immunol, 108, 1027, 10.1067/mai.2001.119154

Niedoszytko, 2009, Mastocytosis and insect venom allergy: diagnosis, safety and efficacy of venom immunotherapy, Allergy, 64, 1237, 10.1111/j.1398-9995.2009.02118.x

Golden, 1996, Discontinuing venom immunotherapy: outcome after five years, J Allergy Clin Immunol, 97, 579, 10.1016/S0091-6749(96)70302-0

Herxeimer, 1951, Bronchial hypersensitization and hyposensitization in man, Int Arch Allergy Appl Immunol, 2, 40, 10.1159/000227899

Taylor, 1972, Local nasal desensitization in allergic rhinitis, Clin Allergy, 2, 125, 10.1111/j.1365-2222.1972.tb01277.x

Taudorf, 1983, Orally administered grass pollen, Allergy, 38, 561, 10.1111/j.1398-9995.1983.tb04140.x

Canonica, 2003, Non injection routes for immunotherapy, J Allergy Clin Immunol, 111, 437, 10.1067/mai.2003.129

Alvarez-Cuesta, 2006, Standards for practical allergen-specific immunotherapy, Allergy, 61, 1, 10.1111/j.1398-9995.2006.01219_1.x

Cox, 2011, Allergen immunotherapy: a practice parameter third update, J Allergy Clin Immunol, 127, S1, 10.1016/j.jaci.2010.09.034

Simioni, 2013, Efficacy of venom immunotherapy given every 3 or 4 months: a prospective comparison with the conventional regimen, Ann Allergy Asthma Immunol, 110, 51, 10.1016/j.anai.2012.09.014

Canonica, 2009, Sublingual immunotherapy: WAO Position Paper 2009. Canonica GW et al edts, Allergy, 64, 3

1993, (EAACI) The European Academy of Allergology and Clinical Immunology, Allergy, 48, 36

World Health Organization Position Paper. Allergen immunotherapy: therapeutical vaccines for allergic diseases. Bousquet J, Lockey R, Malling HJ edts. Allergy 1998;102:558–62.

Muller, 1990, Insect sting allergy – Clinical picture, diagnosis and treatment, Gustav Fischer Ed, 3, 33

Cox, 2010, Speaking the same language: The World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System, J Allergy Clin Immunol, 125, 569, 10.1016/j.jaci.2009.10.060

Simons, 2010, Anaphylaxis, J Allergy Clin Immunol, 125, S161, 10.1016/j.jaci.2009.12.981

Simons, 2012, 2012 Update: World Allergy Organization Guidelines for the assessment and management of anaphylaxis, Curr Opin Allergy Clin Immunol, 12, 389, 10.1097/ACI.0b013e328355b7e4

1986, CSM update. Desensitizing vaccines, Br Med J, 293, 948, 10.1136/bmj.293.6552.948

Rands, 1980, Anaphylactic reaction to desensitization for allergic rhinitis and asthma, BMJ, 281, 854, 10.1136/bmj.281.6244.854

Rands, 1983, Side effects of desensitization for allergy: a general practice survey, J R Coll Gen Pract, 33, 647

Cox, 2009, Comparison of allergen immunotherapy practice patterns in the United States and Europe, Ann Allergy Asthma Immunol, 103, 451, 10.1016/S1081-1206(10)60259-1

Reid, 1992, Survey of fatalities from skin testing and immunotherapy 1985-1989. J Allergy Clin Immunol. 1993;92(1 Pt 1):6-15Stewart GE, Lockey RF Systemic reactions from allergen immunotherapy, J Allergy Clin Immunol, 90, 567

Epstein, 2009, Fatal and Systemic Reactions to Subcutaneous Immunotherapy: ACAAI/AAAAI National Surveillence Study After One Year, Ann Allergy Asthma Immunol, 103, A23

Rank, 2008, Allergen immunotherapy safety: Characterizing systemic reactions and identifying risk factors, Allergy Asthma Proc, 29, 400, 10.2500/aap.2008.29.3141

Lockey, 2001, Systemic reactions and fatalities associated with allergen immunotherapy, Ann Allergy Asthma Immunol, 87, 47, 10.1016/S1081-1206(10)62195-3

Amin, 2006, Evaluation of near-fatal reactions to allergen-immunotherapy injections, J Allergy Clin Immunol, 117, 169, 10.1016/j.jaci.2005.10.010

Epstein, 2013, AAAi and ACAAI surveillance study of subcutaneous immuntherapy: year 3. What pracice modify the risk of systemic reactions?, Ann Allergy Asthma Immunol, 110, 274, 10.1016/j.anai.2013.01.015

Windom, 2008, An update on the safety of specific immunotherapy, Curr Opin Allergy Clin Immunol, 8, 571, 10.1097/ACI.0b013e32831845fb

Malling, 1998, Immunotherapy as an effective tool in allergy treatment, Allergy, 53, 461, 10.1111/j.1398-9995.1998.tb04082.x

Schiappoli, 2009, A prospective Italian survey on the safety of subcutaneous immunotherapy for respiratory allergy, Clin Exp Allergy, 39, 1569, 10.1111/j.1365-2222.2009.03286.x

Schiappoli M, Ridolo E, Senna G, et al. A prospective Italian survey on the safety of subcutaneous immunotherapy for respiratory allergy. Clin Exp Allergy. 2009;39:1569–74.

Aaronson, 2004, Incorrect allergy injections: allergists’ experiences and recommendations for prevention, J Allergy Clin Immunol, 113, 1117, 10.1016/j.jaci.2004.01.756

Roy, 2007, Increased frequency of large local reactions among systemic reactors during subcutaneous allergen immunotherapy, Ann Allergy Asthma Immunol, 99, 82, 10.1016/S1081-1206(10)60626-6

Linneberg, 2012, Allergen-specific immunotherapy and risk of autoimmune disease, Curr Opin Allergy Clin Immunol, 12, 635, 10.1097/ACI.0b013e3283588c8d

Shaikh, 1993, A retrospective study on the safety of immunotherapy in pregnancy, Clin Exp Allergy, 23, 857, 10.1111/j.1365-2222.1993.tb00264.x

Shaikh, 2012, A prospective study on the safety of sublingual immunotherapy in pregnancy, Allergy, 67, 741, 10.1111/j.1398-9995.2012.02815.x

Marshall, 1999, AIDS, HIV-positive patients, and allergies, Allergy Asthma Proc, 20, 301, 10.2500/108854199778251979

Hepner, 1990, Risk of systemic reactions in patients taking beta-blocker drugs receiving allergen immunotherapy injections, J Allergy Clin Immunol, 86, 407, 10.1016/S0091-6749(05)80105-8

Ohashi, 2006, Effect of pretreatment with fexofenadine on the safety of immunotherapy in patients with allergic rhinitis, Ann Allergy Asthma Immunol, 96, 600, 10.1016/S1081-1206(10)63556-9

Canonica, 2014, Sublingual immunotherapy: World Allergy Organization position paper 2013 update, World Allergy Organ J, 7, 6, 10.1186/1939-4551-7-6

Bonifazi, 2005, Prevention and treatment of hymenoptera venom allergy: guidelines for clinical practice, Allergy, 60, 1459, 10.1111/j.1398-9995.2005.00960.x

Brown, 2003, Ant venom immunotherapy: a double-blind placebo-controlled, crossover trial, Lancet, 361, 1001, 10.1016/S0140-6736(03)12827-9

Oude-Elberink, 2009, Immunotherapy improves health-related quality of life of adult patients with dermal reactions following yellow jacket stings, Clin Exp Allergy, 39, 883, 10.1111/j.1365-2222.2009.03230.x

Sasvary, 1994, Fatalities from insect sting from 1978 to 1987, Schweiz Med Wochenschr, 124, 1887

Müller, 2007, Cardiovascular disease and anaphylaxis, Curr Opin Allergy Clin Immunol, 7, 337, 10.1097/ACI.0b013e328259c328

Brown, 2012, Ultrarush versus semirush initiation of insect venom immunotherapy: a randomized controlled trial, J Allergy Clin Immunol, 130, 162, 10.1016/j.jaci.2012.02.022

Müller, 2005, Use of betablockers during immunotherapy for Hymenoptera venom allergy, J Allergy Clin Immunol, 115, 606, 10.1016/j.jaci.2004.11.012

Ruëff, 2010, Predictors of side effects during the buildup phase of venom immunotherapy for Hymenoptera venom allergy: The importance of baseline serum tryptase, J Allergy Clin Immunol, 126, 105, 10.1016/j.jaci.2010.04.025

Bonadonna, 2010, Mastocytosis and insect venom allergy, Curr Opin Clin Allergy Immunol, 10, 347, 10.1097/ACI.0b013e32833b280c

Bilo, 2010, Purified vs non purified venom immunotherapy, Curr Opin Allergy Clin Immunol, 10, 330, 10.1097/ACI.0b013e328339f2d1

Rueff, 2004, Specific immunotherapy in honey bee venom allergy: a comparative study using aqueous and aluminium hydroxide adsorbed preparations, Allergy, 59, 589, 10.1111/j.1398-9995.2004.00505.x

Simons, 2013, World Allergy Organization Anaphylaxis Guidelines: 2013 Update of the Evidence Base, Int Arch Allergy Immunol, 162, 193, 10.1159/000354543

Müller, 2008, Clinical and immunologic effects of H1 antihistamine preventive medication during honeybee venomimmunotherapy, J Allergy Clin Immunol, 122, 1001, 10.1016/j.jaci.2008.08.007

Galera, 2009, Severe anaphylaxis to bee venom immunotherapy: efficacy of pretreatment and concurrent treatment with omalizumab, J Investig Allergol Clin Immunol, 19, 225

Yeung, 2012, Oral immunotherapy for milk allergy, Cochrane Database of Syst Rev, 11, CD009542

Nurmatov, 2014, Effectiveness and safety of orally administered immunotherapy for food allergies: a systematic review and meta-analysis, Br J Nutr, 111, 12, 10.1017/S0007114513002353

Beyer, 2012, A European perspective on immunotherapy for food allergies, J Allergy Clin Immunol, 129, 1179, 10.1016/j.jaci.2012.03.037

Anagnostou, 2014, Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial, Lancet, 383, 1297, 10.1016/S0140-6736(13)62301-6

Wood, 2014, Oral immunotherapy for the treatment of peanut allergy: is it ready for prime time?, JACI: In Practice, 2, 97

Muraro, 2014, EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy, Allergy, 69, 1008, 10.1111/all.12429

Lucendo, 2014, Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a systematic review with meta-analysis, Ann Allergy Asthma Immunol, 113, 624, 10.1016/j.anai.2014.08.004

Cernadas, 2010, General considerations on rapid desensitization for drug hypersensitivity - a consensus statement, Allergy, 65, 1357, 10.1111/j.1398-9995.2010.02441.x

Scherer, 2013, Desensitization in delayed drug hypersensitivity reactions - an EAACI position paper of the Drug Allergy Interest Group, Allergy, 68, 844, 10.1111/all.12161

Legere, 2009, A safe protocol for rapid desensitization in patients with cystic fibrosis and antibiotic hypersensitivity, J Cyst Fibros, 8, 418, 10.1016/j.jcf.2009.08.002

Gastaminza, 2011, A new rapid desensitization protocol for chemotherapy agents, J Investig Allergol Clin Immunol, 21, 108

Castells, 2008, Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases, J Allergy Clin Immunol, 122, 574, 10.1016/j.jaci.2008.02.044

Stevenson, 1984, Aspirin-sensitive rhinosinusitis asthma: a double-blind crossover study of treatment with aspirin, J Allergy Clin Immunol, 73, 500, 10.1016/0091-6749(84)90361-0

Kitazawa, 2006, Successful vancomycin desensitization with a combination of rapid and slow infusion methods, Intern Med, 45, 317, 10.2169/internalmedicine.45.1388

Kobashi, 2010, Desensitization therapy for allergic reactions to antituberculous drugs, Intern Med, 49, 2297, 10.2169/internalmedicine.49.3590

Rossini, 2008, Aspirin desensitization in patients undergoing percutaneous coronary interventions with stent implantation, Am J Cardiol, 101, 786, 10.1016/j.amjcard.2007.10.045

Slowik, 2009, Aspirin desensitization in a patient with aspirin sensitivity and chronic idiopathic urticaria, Ann Allergy Asthma Immunol, 102, 171, 10.1016/S1081-1206(10)60252-9

Cernadas, 2013, Desensitization to antibiotics in children, Pediatr Allergy Immunol, 24, 3, 10.1111/pai.12001

de Groot, 2010, Clinical Practice: drug desensitization in children, Eur J Pediatr, 169, 1305, 10.1007/s00431-010-1236-1

Hope, 2009, Rational approach to aspirin dosing during oral challenges and desensitization of patients with aspirin-exacerbated respiratory disease, J Allergy Clin Immunol, 123, 406, 10.1016/j.jaci.2008.09.048

Wong, 2000, Rapid oral challenge-desensitization for patients with aspirin-related urticaria-angioedema, J Allergy Clin Immunol, 105, 997, 10.1067/mai.2000.104571

Feldweg, 2005, Rapid desensitization for hypersensitivity reactions to paclitaxel and docetaxel: a new standard protocol used in 77 successful treatments, Gynecol Oncol, 96, 824, 10.1016/j.ygyno.2004.11.043

Brennan, 2009, Hypersensitivity reactions to mAbs: 105 desensitizations in 23 patients, from evaluation to treatment, J Allergy Clin Immunol, 124, 1259, 10.1016/j.jaci.2009.09.009

Whitaker, 2011, Rapid desensitization for non-immediate reactions in patients with cystic fibrosis, J Cyst Fibros, 10, 282, 10.1016/j.jcf.2011.02.002

Breslow, 2009, Acetylsalicylic acid and montelukast block mast cell mediator-related symptoms during rapid desensitization, Ann Allergy Asthma Immunol, 102, 155, 10.1016/S1081-1206(10)60247-5

Madrigal-Burgaleta, 2013, Hypersensitivity and desensitization to antineoplastic agents: outcomes of 189 procedures with a new short protocol and novel diagnostic tools assessment, Allergy, 68, 853, 10.1111/all.12105

Eisenhauer, 1994, European-Canadian randomized trial of paclitaxel in relapsed ovarian cancer: high-dose versus low-dose and long versus short infusion, J Clin Oncol, 12, 2654, 10.1200/JCO.1994.12.12.2654

White, 2006, Effect of leukotriene modifier drugs on the safety of oral aspirin challenges, Ann Allergy Asthma Immunol, 97, 688, 10.1016/S1081-1206(10)61101-5

Long, 2014, Incidence of malignancy in patients with moderate-to-severe asthma treated with or without omalizumab, J Allergy Clin Immunol, 134, 560, 10.1016/j.jaci.2014.02.007

Jensen-Jarolim, 2008, AllergoOncology: the role of IgE-mediated allergy in cancer, Allergy, 63, 1255, 10.1111/j.1398-9995.2008.01768.x

Cooper, 2008, Geohelminth infections: a review of the role of IgE and assessment of potential risks of anti-IgE treatment, Allergy, 63, 409, 10.1111/j.1398-9995.2007.01601.x

Leiva-Salinas, 2014, Effectiveness and safety of omalizumab in a patient with chronic urticaria and hepatitis C. J Eur Acad Dermatol Venereol. 2015;29:1027-8Baena-Cagnani CE, Gómez RM. Current status of therapy with omalizumab in children, Curr Opin Allergy Clin Immunol, 14, 149

Baena-Cagnani, 2014, Current status of therapy with omaizumab in children, Curr Opin Allergy Clin Immunol, 14, 149, 10.1097/ACI.0000000000000044

Somerville, 2014, Immunogenicity and safety of omalizumab in pre-filled syringes in patients with allergic (IgE-mediated) asthma, Curr Med Res Opin, 30, 59, 10.1185/03007995.2013.844115

Chipps, 2012, Omalizumab: an update on efficacy and safety in moderate-to-severe allergic asthma, Allergy Asthma Proc, 33, 377, 10.2500/aap.2012.33.3599

Thomson, 2012, Omalizumab: clinical use for the management of asthma, Clin Med Insights Circ Respir Pulm Med, 6, 27, 10.4137/CCRPM.S7793

Corren, 2009, Safety and tolerability of omalizumab, Clin Exp Allergy, 39, 788, 10.1111/j.1365-2222.2009.03214.x

Maurer, 2013, Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria, N Engl J Med, 7, 924, 10.1056/NEJMoa1215372

Kim, 2010, Omalizumab: Practical considerations regarding the risk of anaphylaxis, Allergy Asthma Clin Immunol, 6, 32, 10.1186/1710-1492-6-32

XOLAIR [prescribing information and medication guide]. South San Francisco, CA: Genentech, Inc; 2014. Accessed at: http://www.xolair.com/.

Cox, 2007, American Academy of Allergy, Asthma, & Immunology; American College of Allergy, Asthma, and Immunology Joint Task Force Report on omalizumab-associated anaphylaxis, J Allergy Clin Immunol, 120, 1373, 10.1016/j.jaci.2007.09.032

Stiehm, 2013, Adverse effects of human immunoglobulin therapy, Transfus Med Rev, 27, 171, 10.1016/j.tmrv.2013.05.004

Chapel, 2013, Subcutaneous immunoglobulin replacement therapy: the European experience, Curr Opin Allergy Clin Immunol, 13, 623, 10.1097/ACI.0000000000000013

Niebur, 2015, Efficacy and tolerability of 16 % subcutaneous immunoglobulin compared with 20 % subcutaneous immunoglobulin in primary antibody deficiency, Clin Exp Immunol, 181, 441, 10.1111/cei.12623

Bork, 2013, Treatment with C1-esterase inhibitor concentrate in type I or II hereditary angioedema: a systematic literature review, Allergy Asthma Proc, 34, 312, 10.2500/aap.2013.34.3677

Bork, 2014, Pasteurized and nanofiltered, plasma-derived C1 esterase inhibitor concentrate for the treatment of hereditary angioedema, Immunotherapy, 6, 533, 10.2217/imt.14.33

Spath, 2015, On the dark side of therapies with immunoglobulin concentrates: the adverse events, Front Immunol, 6, 11, 10.3389/fimmu.2015.00011

Simons, 2011, World Allergy Organization Guidelines for the assessment and management of anaphylaxis, WAO Journal, 4, 13

Simons, 2014, International consensus on (ICON) anaphylaxis, World Allergy Org J, 7, 9, 10.1186/1939-4551-7-9

Muraro, 2014, Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology, Allergy, 69, 1026, 10.1111/all.12437

Spaner, 1989, Hypersensitivity to natural latex, J Allergy Clin Immunol, 83, 1135, 10.1016/0091-6749(89)90457-0

Bonnekoh, 1992, Safety of latex prick skin testing in allergic patients, JAMA, 267, 2603, 10.1001/jama.1992.03480190045019

Nicolaou, 2002, Anaphylaxis following prick testing with natural rubber latex, Contact Dermatitis, 47, 251, 10.1034/j.1600-0536.2002.470422.x