Risk Factors for Acute Retinopathy of Prematurity

Annals of Ophthalmology - Tập 39 - Trang 107-111 - 2007
Saleh A. Al-Amro1, Turki M. Al-Kharfi2, Abdulla A. Thabit1, Saleh M. Al-Mofada2
1Department of Ophthalmology, King Abdulaziz University, Riyadh, Kingdom of Saudi Arabia
2Department of Pediatrics at the School of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia

Tóm tắt

We prospectively studied the risk factors and the incidence of retinopathy of prematurity (ROP) in 195 consecutive preterm infants. Birth weight and duration of mechanical ventilation were the only factors significantly associated with the incidence of ROP. While indomethacin increases the risk of developing ROP, maternal antenatal steroids have a protective effect against the development of severe stages of ROP. The presence of intraventricular hemorrhage increases the risk of severe ROP.

Tài liệu tham khảo

McNamara JA, Moreno R, Tasman WS. Retinopathy of prematurity. In: Tasman W, Jaeger EA, eds. Duane’s Clinical Ophthalmology. Vol. 3, Philadelphia: Lippincott-Raven, 1996. Ch. 10 Pierce EA, Petersen RA, Smith LE. Retinopathy of prematurity. In: Albert D, Jakoiec F, eds. Principles and Practice of Ophthalmology. Philadelphia: W.H. Saunders Co., 2000: pp. 4443–4460 Phleps DL. Vitamin E and retrolental fibroplasias in 1982. Pediatrics 1982;70:420–424 Al-Amro SA, Al-Kharfi TM, Thabit AA, et al. Retinopathy of prematurity at King Khaled University Hospital in Riyadh. Saudi Med J 2003;24:720–724 Hunter DG, Mukai S. Retinopathy of prematurity: Pathogenesis, diagnosis and treatment. Int Ophthalmol Clin 1992;32:163–184 Compbell PB, Bull MJ, Ellis FD. Incidence of retinopathy of prematurity in a tertiary newborn Intensive Care unit. Arch Ophthalmol 1983;101:1686–1688 Quinn GE, Johnson L, Abbasi S. Onset of retinopathy of prematurity as related to post natal and postconceptional age. Br J Ophthalmol 1992;76:284–288 Kinsey VE, Jacobus JT, Hemphill FM. Cooperative study of retrolental fibroplasia and the use of oxygen. Arch Ophthalmol 1956;56:481–529 Flyn JT, Bancalari E, Snyder SE. A cohort study of transcutaneous oxygen tension and the incidence and severity of retinopathy of prematurity. N Engl J Med 1992;326:1050–1054 Lucey JF, Dangman B. A reexamination of the role of oxygen in retrolental fibroplasias. Pediatrics 1984;73:82–96 Owens WC, Owens EU. Retrolental fibroplasia in premature infants: II. Studies on the prophylaxis of the disease: The use of alphatocopheryl acetate. Am J Ophthalmol 1949;32:497–505 Hittner HM, Godio LB, Rudolph AJ. Retrolental fibroplasia: Efficacy of vitamin E in a double-blind clinical study of preterm infants. N Engl J Med 1981;305:1365–1371 Finer NN, Grant G, Schindler RF. Effect of intramuscular vitamin E on frequency and severity of retrolental fibroplasia: a controlled trial. Lancet 1982;1:1087–1091 Johnson L, Quinn GE, Abbasi S, et al. Effect of sustained pharmacologic vitamin E levels on incidence and severity of retinopathy of prematurity: A controlled clinical trial. J Pediatr 1989;114:827–838 Puklin JE, Simon RM, Ehrenkranz RA. Influence on retrolental fibroplasia of intramuscular vitamin E administration during respiratory distress syndrome. Ophthalmology 1982;89:96–102 Milner RA, Bell E, Blanchette V. Vitamin E supplement in under 1,500 g neonates. Retinopathy of prematurity conference, December 4–6, 1981. Columbus, OH: Ross Laboratories, 1981;703–716 Phelps DL, Rosenbaum AL, Isenberg SJ. Tocopherol efficacy and safety for preventing retinopathy of prematurity: A randomized, controlled, double-masked trial. Pediatrics 1987;79:489–500 Committee of the Institute of Medicine. A report of a study - vitamin E, retinopathy of prematurity. IOM-86-02. Washington, DC: National Academy Press, 1986 Ehrenkranz RA. Vitamin E and retinopathy of prematurity: Still controversial. J Pediatr 1989;114:801–803 Brown DR, Biglan AW, Stretavsky MM. Retinopathy of prematurity: The relationship with intraventricular hemorrhage and bronchopulmonary dysplasia. J Pediatr Ophthalmol Strabismus 1990;27:268–271 Bassiouny MR. Risk factors associated with retinopathy of prematurity: A study from Oman. J Trop Pediatr 1996;42:355–358 Arroe M, Peitersen B. Retinopathy of prematurity: Review of a seven-year period in a Danish neonatal intensive care unit. Acta Paediatr 1994;83:501–505 Batton DG, Roberts C, Trese M. Severe retinopathy of prematurity and steroid exposure. Pediatrics 1992;90:534–536 Flower RW, Blake DA, Wajer SD. Retrolental fibroplasia: Evidence for a role of the prostaglandin cascade in the pathogenesis of oxygen-induced retinopathy in the newborn beagle. Pediatr Res 1981;15:1293–1302 Schmidt B, Davis P, Moddemann D. Long-term effects of indomethacin prophylaxis in extremely low birth weight infants. N Engl J Med 2001;28:1966–1972 Bandstra ES, Montalvo BM, Goldberg RN. Prophylactic indomethacin for prevention of intraventricular hemorrhage in premature infants. Pediatrics 1988;82:533–542 Yeh TF, Raval D, Pyati S, et al. Retinopathy of prematurity and indomethacin therapy in premature infants with patent ductus arteriosus. Prostaglandins 1983;25:385–391 Darlow BA, Horwood LJ, Clement ERS. Retinopathy of prematurity: Risk factors in a prospective population-based study. Paediatr Perinat Epidemiol 1992;6:62–80 Nandgaonkar BN, Rotschild T, Yuk, Higgins RD. Indomethacin improves oxygen-induced retinopathy in the mouse. Pediatr Res 1999;46:184–188 Beauchamp MH, Martinez-Bermudez AK, Gobeil F Jr, et al. Role of thromboxane in retinal microvascular degeneration in oxygen-induced retinopathy. J Appl Physiol 2001;90:2279–2288 Stuart MJ, Phelps DL, Setty BN. Changes in oxygen tension and effects on cyclooxygenase metabolites: III. Decrease of retinal prostacyclin in kittens exposed to hyperoxia. Pediatrics 1999;82:367–372 Harold J, Schmidt B. Evidence-based neonatology; making a difference beyong discharge from the neonatal nursery. Curr Opin Pediatr 2002;14:165–169 Knight DB. The treatment of patent ductus arteriosus in preterm infants. A review and overview of randomized trials. Semin Neonatal 2001;6:63–73 Rowlands E. Ionides AC, Chinn S, et al. Reduced incidence of retinopathy of prematurity. Br J Ophthalmol 2001;85:933–935 Console V, Gagliardi L, De Giorgi A, et al. Retinopathy of prematurity and antenatal corticosteroids. The Italian ROP Study Group. Acta Bio-Med Ateneo parm 1997;68(Suppl 1):75–79 Blair BM, O’Halloran HS, Pauly TH, Stevens JL. Decreased incidence of retinopathy of prematurity 1995–1997. J AAPOS 2001;5:118–122