Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish

Alcarazpérez, 2008, Application of the dual-luciferase reporter assay to the analysis of promoter activity in Zebrafish embryos, BMC Biotechnol., 8, 81, 10.1186/1472-6750-8-81 Avruch, 2009, Amino acid regulation of TOR complex 1, Am. J. Physiol. Endocrinol. Metab., 296, e592, 10.1152/ajpendo.90645.2008 Bielczyk-Maczyńska, 2015, The ribosome biogenesis protein Nol9 is essential for definitive hematopoiesis and pancreas morphogenesis in zebrafish, PLoS Genet., 11, 10.1371/journal.pgen.1005677 Boglev, 2013, Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis, PLoS Genet., 9, 10.1371/journal.pgen.1003279 Boultwood, 2013, Activation of the mTOR pathway by the amino acid (L)-leucine in the 5q-syndrome and other ribosomopathies, Adv. Biol. Regul., 53, 8, 10.1016/j.jbior.2012.09.002 Buszczak, 2014, Cellular differences in protein synthesis regulate tissue homeostasis, Cell, 159, 242, 10.1016/j.cell.2014.09.016 Dez, 2004, Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification, Mol. Cell. Biol., 24, 6324, 10.1128/MCB.24.14.6324-6337.2004 Dibble, 2015, Regulation of mTORC1 by PI3K signaling, Trends Cell Biol., 25, 545, 10.1016/j.tcb.2015.06.002 Dibble, 2013, Signal integration by mTORC1 coordinates nutrient input with biosynthetic output, Nat. Cell Biol., 15, 555, 10.1038/ncb2763 Doudna, 2002, Structure and function of the eukaryotic ribosome: the next frontier, Cell, 109, 153, 10.1016/S0092-8674(02)00725-0 Ear, 2016, A zebrafish model of 5q-syndrome using CRISPR/Cas9 targeting RPS14 reveals a p53-independent and p53-dependent mechanism of erythroid failure, J. Genet. Genomics, 43, 307, 10.1016/j.jgg.2016.03.007 Field, 2003, Formation of the digestive system in zebrafish. I. Liver morphogenesis, Dev. Biol., 253, 279, 10.1016/S0012-1606(02)00017-9 Freed, 2010, The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis, Nucleic Acids Res., 38, 4798, 10.1093/nar/gkq185 Gangloff, 2004, Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development, Mol. Cell. Biol., 24, 9508, 10.1128/MCB.24.21.9508-9516.2004 García-Gómez, 2014, Final pre-40S maturation depends on the functional integrity of the 60S subunit ribosomal protein L3, PLoS Genet., 10, 10.1371/journal.pgen.1004205 Guertin, 2006, Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1, Dev. Cell, 11, 859, 10.1016/j.devcel.2006.10.007 He, 2014, Regeneration of liver after extreme hepatocyte loss occurs mainly via biliary transdifferentiation in zebrafish, Gastroenterology, 146, 789, 10.1053/j.gastro.2013.11.045 Iadevaia, 2012, Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis, Methods Mol. Biol., 821, 171, 10.1007/978-1-61779-430-8_10 Iadevaia, 2014, mTORC1 signaling controls multiple steps in ribosome biogenesis, Semin. Cell Dev. Biol., 36, 113, 10.1016/j.semcdb.2014.08.004 Kim, 2013, Nutrient regulation of the mTOR complex 1 signaling pathway, Mol. Cells, 35, 463, 10.1007/s10059-013-0138-2 Lafontaine, 2001, The function and synthesis of ribosome, Nat. Rev. Mol. Cell Biol., 2, 514, 10.1038/35080045 Liu, 2016, Macrophages mediate the repair of brain vascular rupture through direct physical adhesion and mechanical traction, Immunity, 44, 1162, 10.1016/j.immuni.2016.03.008 Liu, 2009, NF-kappaB and Snail1a coordinate the cell cycle with gastrulation, J. Cell Biol., 184, 805, 10.1083/jcb.200806074 Lu, 2009, EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development, Dev. Cell, 24, 543, 10.1016/j.devcel.2013.01.021 Makky, 2007, Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine, Dev. Biol., 303, 501, 10.1016/j.ydbio.2006.11.030 Mayer, 2003, Nil per os encodes a conserved RNA recognition motif protein required for morphogenesis and cytodifferentiation of digestive organs in zebrafish, Development, 130, 3917, 10.1242/dev.00600 Murakami, 2004, mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells, Mol. Cell. Biol., 24, 6710, 10.1128/MCB.24.15.6710-6718.2004 Payne, 2012, L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del (5q) MDS by activating the mTOR pathway, Blood, 120, 2214, 10.1182/blood-2011-10-382986 Pópulo, 2012, The mTOR signalling pathway in human cancer, Int. J. Mol. Sci., 13, 1886, 10.3390/ijms13021886 Provost, 2013, Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development, Zebrafish, 10, 161, 10.1089/zeb.2013.0884 Qin, 2014, Nom1 mediates pancreas development by regulating ribosome biogenesis in zebrafish, PLoS One, 9 Rosado, 2004, Npa1p is an essential trans-acting factor required for an early step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae, RNA, 10, 1073, 10.1261/rna.7340404 Rui, 2007, A link between protein translation and body weight, J. Clin. Invest., 117, 310, 10.1172/JCI31289 Shestopaloff, 2014, Method for finding metabolic properties based on the general growth law. Liver examples. A general framework for biological modeling, PLoS One, 9, 10.1371/journal.pone.0099836 Sofer, 2005, Regulation of mTOR and cell growth in response to energy stress by REDD1, Mol. Cell. Biol., 25, 5834, 10.1128/MCB.25.14.5834-5845.2005 Strunk, 2012, A translation-like cycle is a quality control checkpoint for maturing 40S ribosome subunits, Cell, 150, 111, 10.1016/j.cell.2012.04.044 von Walden, 2016, mTOR signaling regulates myotube hypertrophy by modulating protein synthesis, rDNA transcription, and chromatin remodeling, Am. J. Physiol. Cell. Physiol., 311, 633, 10.1152/ajpcell.00144.2016 Wang, 2006, Overexpression of ribosomal protein L15 is associated with cell proliferation in gastric cancer, BMC Cancer, 6, 91, 10.1186/1471-2407-6-91 Wang, 2015, Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications, Med. Res. Rev., 35, 225, 10.1002/med.21327 Westerfield, 2007 Wullschleger, 2006, TOR signaling in growth and metabolism, Cell, 124, 471, 10.1016/j.cell.2006.01.016 Yang, 2011, Depletion of Bhmt elevates sonic hedgehog transcript level and increases β-cell number in zebrafish, Endocrinology, 152, 4706, 10.1210/en.2011-1306 Yelick, 2015, Ribosomopathies: global process, tissue specific defects, Rare Dis., 3 Zhou, 2009, mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells, Proc. Natl. Acad. Sci. U. S. A., 106, 7840, 10.1073/pnas.0901854106