Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease

Cell - Tập 157 - Trang 472-485 - 2014
Ian Martin1,2,3, Jungwoo Wren Kim1,4,3, Byoung Dae Lee1,2,5, Ho Chul Kang1,2,6, Jin-Chong Xu1,2, Hao Jia1,4,3, Jeannette Stankowski1,2,3, Min-Sik Kim7,8, Jun Zhong9, Manoj Kumar1,2, Shaida A. Andrabi1,2,3, Yulan Xiong1,2, Dennis W. Dickson10, Zbigniew K. Wszolek11, Akhilesh Pandey7,12,13,8,3,14, Ted M. Dawson1,2,15,3, Valina L. Dawson1,2,4,15,3
1Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
3Adrienne Helis Malvin Medical Research Foundation, New Orleans, LA 70130, USA
4Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
5Age-Related and Brain Disease Research Center, Department of Neuroscience, Kyung Hee University, Seoul 130-701, South Korea
6Department of Physiology, Ajou University School of Medicine, Suwon 443-749, South Korea
7Department of Biological Chemistry, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
8McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
9McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
10Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
11Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA
12Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
13Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
14Diana Helis Henry Medical Research Foundation, New Orleans, LA 70130, USA
15Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

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