RhoD localization and function is dependent on its GTP/GDP-bound state and unique N-terminal motif

Aspenström, 2004, Rho GTPases have diverse effects on the organization of the actin filament system, Biochem. J., 377, 327, 10.1042/bj20031041 Aspenström, 2007, Taking Rho GTPases to the next level: the cellular functions of atypical Rho GTPases, Exp. Cell Res., 313, 3673, 10.1016/j.yexcr.2007.07.022 Blom, 2015, RhoD is a Golgi component with a role in anterograde protein transport from the ER to the plasma membrane, Exp. Cell Res., 333, 208, 10.1016/j.yexcr.2015.02.023 Blom, 2017, The atypical Rho GTPase RhoD is a regulator of actin cytoskeleton dynamics and directed cell migration, Exp. Cell Res., 352, 255, 10.1016/j.yexcr.2017.02.013 Chavrier, 1992, The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach, Gene, 112, 261, 10.1016/0378-1119(92)90387-5 Cherfils, 2013, Regulation of small GTPases by GEFs, GAPs, and GDIs, Physiol. Rev., 93, 269, 10.1152/physrev.00003.2012 Feig, 1988, Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP, Mol. Cell. Biol., 8, 3235 Gad, 2012, RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules, Mol. Biol. Cell, 23, 4807, 10.1091/mbc.e12-07-0555 Gasman, 2003, RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase, Nat. Cell Biol., 5, 195, 10.1038/ncb935 Hodge, 2016, Regulating Rho GTPases and their regulators, Nat. Rev. Mol. Cell. Biol., 17, 496, 10.1038/nrm.2016.67 Jaffe, 2005, Rho GTPases: biochemistry and biology, Annu. Rev. Cell. Dev. Biol., 21, 247, 10.1146/annurev.cellbio.21.020604.150721 Jaiswal, 2013, New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm, Biol. Chem., 394, 89, 10.1515/hsz-2012-0207 Murphy, 1996, Endosome dynamics regulated by a Rho protein, Nature, 384, 427, 10.1038/384427a0 Murphy, 2001, Dual function of RhoD in vesicular movement and cell motility, Eur. J. Cell Biol., 80, 391, 10.1078/0171-9335-00173 Nehru, 2013, RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor, Traffic, 14, 1242, 10.1111/tra.12121 Pols, 2009, Trafficking and function of the tetraspanin CD63, Exp. Cell Res., 315, 1584, 10.1016/j.yexcr.2008.09.020 Traut, 1994, Physiological concentrations of purines and pyrimidines, Mol. Cell Biochem., 140, 1, 10.1007/BF00928361 Tsubakimoto, 1999, Small GTPase RhoD suppresses cell migration and cytokinesis, Oncogene, 18, 2431, 10.1038/sj.onc.1202604 Zhang, 2011, GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration, Mol. Biol. Cell, 22, 2119, 10.1091/mbc.e10-12-0969