Rheumatoid arthritis is linked to oral bacteria: etiological association

Mesut Öğrendik1,2
1Altintas mah Kocacami cad, Erten Kocabay Apt, No:2 Kat:6, 09800 Nazilli, Aydin, Turkey
2Division of Rheumatology, Nazilli State Hospital, Nazilli, Turkey

Tóm tắt

Từ khóa


Tài liệu tham khảo

Tatakis DN, Kumar PS. Etiology and pathogenesis of periodontal diseases. Dent Clin North Am. 2005;49:491–516.

Greenwald RA, Kirkwood K. Adult periodontitis as a model for rheumatoid arthritis (with emphasis on treatment strategies). J Rheumatol. 1999;26:1650–3.

Mercado FB, Marshall RI, Klestov AC, Bartold PM. Relationship between rheumatoid arthritis and periodontitis. J Periodontol. 2001;72:779–87.

Rosenstein ED, Greenwald RA, Kushner LJ, Weissmann G. Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation. 2004;28:311–8.

Moen K, Brun JG, Madland TM, Tynning T, Jonsson R. Immunoglobulin G and A antibody responses to Bacteroides forsythus and Prevotella intermedia in sera and synovial fluids of arthritis patients. Clin Diagn Lab Immunol. 2003;10:1043–50.

Ogrendik M, Kokino S, Ozdemir F, Bird PS, Hamlet S. Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis. MedGenMed. 2005 Jun 16;7(2):2. http://www.medscape.com/viewarticle/505458 . Accessed 16 June 2005.

Moen K, Brun JG, Valen M, et al. Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs. Clin Exp Rheumatol. 2006;24:656–63.

Ogrendik M, Hakguder A, Keser N. Treatment of rheumatoid arthritis with ornidazole. A randomized, double-blind, placebo-controlled study. Rheumatology (Oxford). 2006;45:636–7.

Ogrendik M. Levofloxacin treatment in patients with rheumatoid arthritis receiving methotrexate. South Med J. 2007;100:135–9.

Ogrendik M. Effects of clarithromycin in patients with active rheumatoid arthritis. Curr Med Res Opin. 2007;23:515–22.

Das KM. Sulfasalazine therapy in inflammatory bowel disease. Gastroenterol Clin North Am. 1989;18:1–20.

Amin AR, Attur MG, Thakker GD, et al. A novel mechanism of action of tetracyclines: effects on nitric oxide synthases. Proc Natl Acad Sci USA. 1996;93:14014–9.

Tilley BC, Alarcon GS, Heyse SP, et al. Minocycline in rheumatoid arthritis. A 48-week, double-blind, placebo-controlled trial. MIRA Trial Group. Ann Intern Med. 1995;122:81–9.

Kloppenburg M, Breedveld FC, Terwiel JP, Mallee C, Dijkmans BA. Minocycline in active rheumatoid arthritis. A double-blind, placebo-controlled trial. Arthritis Rheum. 1994;37:629–36.

O’Dell JR, Haire CE, Palmer W, et al. Treatment of early rheumatoid arthritis with minocycline or placebo: results of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 1997;40:842–8.

O’Dell JR, Paulsen G, Haire CE, et al. Treatment of early seropositive rheumatoid arthritis with minocycline: four-year followup of a double-blind, placebo-controlled trial. Arthritis Rheum. 1999;42:1691–5.

Moreland LW, Baumgartner SW, Schiff MH, et al. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med. 1997;337:141–7.

Seymour GJ, Gemmell E. Cytokines in periodontal disease: where to from here? Acta Odontol Scand. 2001;59:167–73.

Yoshimura A, Hara Y, Kaneko T, Kato I. Secretion of IL-1 beta, TNF-alpha, IL-8 and IL-1ra by human polymorphonuclear leukocytes in response to lipopolysaccharides from periodontopathic bacteria. J Periodontal Res. 1997;32:279–86.

Kjeldsen M, Holmstrup P, Lindemann RA, Bendtzen K. Bacterial-stimulated cytokine production of peripheral mononuclear cells from patients of various periodontitis categories. J Periodontol. 1995;66:139–44.

Rossano F, Rizzo A, Sanges MR, Cipollaro de L’Ero G, Tufano MA. Human monocytes and gingival fibroblasts release tumor necrosis factor-alpha, interleukin-1 alpha and interleukin-6 in response to particulate and soluble fractions of Prevotella melaninogenica and Fusobacterium nucleatum. Int J Clin Lab Res. 1993;23:165–8.

Robinson AJ, Taylor DH, Wright GD. Infliximab therapy reduces periodontoid rheumatoid pannus formation. Rheumatology (Oxford). 2008;47:225–6.

McGraw WT, Potempa J, Farley D, Travis J. Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun. 1999;67:3248–56.

Gargiulo AV Jr, Robinson J, Toto PD, Gargiulo AW. Identification of rheumatoid factor in periodontal disease. J Periodontol. 1982;53:568–77.

Thé J, Ebersole JL. Rheumatoid factor (RF) distribution in periodontal disease. J Clin Immunol. 1991;11:132–42.

Tighe H, Carson DA. Rheumatoid factor. In: Ruddy S, Harris Jr. ED, Sledge CB, editors. Kelley’s textbook of rheumatology. Philadelphia: WB Saunders; 2001. p. 151–60.

Bonagura VR, Artandi SE, Davidson A, et al. Mapping studies reveal unique epitopes on IgG recognized by rheumatoid arthritis-derived monoclonal rheumatoid factors. J Immunol. 1993;151:3840–52.

Martin T, Crouzier R, Weber JC, Kipps TJ, Pasquali JL. Structure-function studies on a polyreactive (natural) autoantibody. Polyreactivity is dependent on somatically generated sequences in the third complementarity-determining region of the antibody heavy chain. J Immunol. 1994;152:5988–96.

Stastny P. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med. 1978;298:869–71.

Katz J, Goultschin J, Benoliel R, Brautbar C. Human leukocyte antigen (HLA) DR4. Positive association with rapidly progressing periodontitis. J Periodontol. 1987;58:607–10.

Gran JT, Husby G, Thorsby E. The association between rheumatoid arthritis and HLA antigen DR4. Ann Rheum Dis. 1983;42:292–6.

Bonfil JJ, Dillier FL, Mercier P, et al. A “case control” study on the role of HLA DR4 in severe periodontitis and rapidly progressive periodontitis. Identification of types and subtypes using molecular biology (PCR.SSO). J Clin Periodontol. 1999;26:77–84.

Lacki JK, Porawska W, Mackiewicz U, Mackiewicz S, Muller W. Changes in agalactosyl IgG levels correlate with radiological progression in early rheumatoid arthritis. Ann Med. 1996;28:265–9.

Haraldsson G, Meurman JH, Kononen E, Holbrook WP. Properties of hemagglutination by Prevotella melaninogenica. Anaerobe. 2005;11:285–9.

Cuesta IA, Sud S, Song Z, Affholter JA, et al. T-cell receptor (V beta) bias in the response of rheumatoid arthritis synovial fluid T cells to connective tissue antigens. Scand J Rheumatol. 1997;26:166–73.

Hall FC, Thomson K, Procter J, McMichael AJ, Wordsworth BP. TCR beta spectratyping in RA: evidence of clonal expansions in peripheral blood lymphocytes. Ann Rheum Dis. 1998;57:319–22.

Leung KP, Torres BA. Prevotella intermedia stimulates expansion of Vbeta-specific CD4(+) T cells. Infect Immun. 2000;68:5420–4.

Mathur A, Michalowicz B, Yang C, Aeppli D. Influence of periodontal bacteria and disease status on V beta expression in T cells. J Periodontal Res. 1995;30:369–73.

Yoshida A, Nakano Y, Yamashita Y, et al. Immunodominant region of Actinobacillus actinomycetemcomitans 40-kilodalton heat shock protein in patients with rheumatoid arthritis. J Dent Res. 2001;80:346–50.

Ando T, Kato T, Ishihara K, Ogiuchi H, Okuda K. Heat shock proteins in the human periodontal disease process. Microbiol Immunol. 1995;39:321–7.

Schett G, Redlich K, Xu Q, et al. Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. J Clin Invest. 1998;102:302–11.

Clague RB, Firth SA, Holt PJ, Skingle J, Greenbury CL, Webley M. Serum antibodies to type II collagen in rheumatoid arthritis: comparison of 6 immunological methods and clinical features. Ann Rheum Dis. 1983;42:537–44.

Ronnelid J, Lysholm J, Engstrom-Laurent A, Klareskog L, Heyman B. Local anti-type II collagen antibody production in rheumatoid arthritis synovial fluid. Evidence for an HLA-DR4-restricted IgG response. Arthritis Rheum. 1994;37:1023–9.

Bedi GS, Williams T. Purification and characterization of a collagen-degrading protease from Porphyromonas gingivalis. J Biol Chem. 1994;269:599–606.

Backlund J, Carlsen S, Hoger T, et al. Predominant selection of T cells specific for the glycosylated collagen type II epitope (263–270) in humanized transgenic mice and in rheumatoid arthritis. Proc Natl Acad Sci USA. 2002;99:9960–5.

Van den Steen PE, Proost P, Grillet B, et al. Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis. FASEB J. 2002;16:379–89.

Imamura T. The role of gingipains in the pathogenesis of periodontal disease. J Periodontol. 2003;74:111–8.

Andersen RB, Elling P. Immunofluorescent demonstration of intracellular fibrin in synovial tissue. Ann Rheum Dis. 1972;31:59–64.

Lundberg K, Kinloch A, Fisher BA, et al. Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase. Arthritis Rheum. 2008;58:3009–19.

Tesmer LA, Lundy SK, Sarkar S, Fox DA. Th17 cells in human disease. Immunol Rev. 2008;223:87–113.

Cardoso CR, Garlet GP, Crippa GE, et al. Evidence of the presence of T helper type 17 cells in chronic lesions of human periodontal disease. Oral Microbiol Immunol. 2009;24:1–6.

Kramer JM, Gaffen SL. Interleukin-17: a new paradigm in inflammation, autoimmunity, and therapy. J Periodontol. 2007;78:1083–93.

Oda T, Yoshie H, Yamazaki K. Porphyromonas gingivalis antigen preferentially stimulates T cells to express IL-17 but not receptor activator of NF-kappaB ligand in vitro. Oral Microbiol Immunol. 2003;18:30–6.