Review of evolving etiologies, implications and treatment strategies for the superior vena cava syndrome
Tóm tắt
Superior vena cava syndrome (SVCS) is a relatively common sequela of mediastinal malignancies and may cause significant patient distress. SVCS is a medical emergency if associated with laryngeal or cerebral edema. The etiologies and management of SVCS have evolved over time. Non-malignant SVCS is typically caused by infectious etiologies or by thrombus in the superior vena cava and can be managed with antibiotics or anti-coagulation therapy, respectively. Radiation therapy (RT) has long been a mainstay of treatment of malignant SVCS. Chemotherapy has also been used to manage SVCS. In the past 20 years, percutaneous stenting of the superior vena cava has emerged as a viable option for SVCS symptom palliation. RT and chemotherapy are still the only modalities that can provide curative treatment for underlying malignant etiologies of SVCS. The first experiences with treating SVCS with RT were reported in the 1970’s, and several advances in RT delivery have subsequently occurred. Hypo-fractionated RT has the potential to be a more convenient therapy for patients and may provide equal or superior control of underlying malignancies. RT may be combined with stenting and/or chemotherapy to provide both immediate symptom palliation and long-term disease control. Clinicians should tailor therapy on a case-by-case basis. Multi-disciplinary care will maximize treatment expediency and efficacy.
Tài liệu tham khảo
Ahmann FR (1984) A reassessment of the clinical implications of the superior vena caval syndrome. J Clin Oncol 2:961–969
Ampil F, Caldito G, Previgliano C (2012) Palliative radiotherapy for superior vena caval obstruction by lung cancer: a major issue about timing and a minor issue about efficacy. Ann Thorac Med 7:170–171. doi:10.4103/1817-1737.98854
Armstrong BA, Perez CA, Simpson JR, Hederman MA (1987) Role of irradiation in the management of superior vena cava syndrome. Int J Radiat Oncol Biol Phys 13:531–539
Baker GL, Barnes HJ (1992) Superior vena cava syndrome: etiology, diagnosis, and treatment. Am J Crit Care 1:54–64
Bekelman JE, Hahn SM (2014) Reference pricing with evidence development: a way forward for proton therapy. J Clin Oncol 32:1540–1542. doi:10.1200/jco.2014.55.6613
Bekelman JE, Asch DA, Tochner Z, Friedberg J, Vaughn DJ, Rash E, Raksowski K, Hahn SM (2014) Principles and reality of proton therapy treatment allocation. Int J Radiat Oncol Biol Phys 89:499–508. doi:10.1016/j.ijrobp.2014.03.023
Chan RH, Dar AR, Yu E, Stitt LW, Whiston F, Truong P, Vincent MD, Kocha WI (1997) Superior vena cava obstruction in small-cell lung cancer. Int J Radiat Oncol Biol Phys 38:513–520
Charnsangavej C, Carrasco CH, Wallace S, Wright KC, Ogawa K, Richli W, Gianturco C (1986) Stenosis of the vena cava: preliminary assessment of treatment with expandable metallic stents. Radiology 161:295–298. doi:10.1148/radiology.161.2.3763891
Chen JC, Bongard F, Klein SR (1990) A contemporary perspective on superior vena cava syndrome. Am J Surg 160:207–211
Cheng S (2009) Superior vena cava syndrome: a contemporary review of a historic disease. Cardiol Rev 17:16–23
Cheung P, Faria S, Ahmed S, Chabot P, Greenland J, Kurien E, Mohamed I, Wright JR, Hollenhorst H, de Metz C, Campbell H, Vu TT, Karvat A, Wai ES, Ung YC, Goss G, Shepherd FA, O’Brien P, Ding K, O’Callaghan C (2014) Phase II study of accelerated hypofractionated three-dimensional conformal radiotherapy for stage T1-3 N0 M0 non-small cell lung cancer: NCIC CTG BR.25. J Natl Cancer Inst. doi:10.1093/jnci/dju164
Davenport D, Ferree C, Blake D, Raben M (1976) Response of superior vena cava syndrome to radiation therapy. Cancer 38:1577–1580. doi:10.1002/1097-0142(197610)38:4<1577:AID-CNCR2820380422>3.0.CO;2-K
Davenport D, Ferree C, Blake D, Raben M (1978) Radiation therapy in the treatment of superior vena caval obstruction. Cancer 42:2600–2603
de Jager CP, Rutten MJ, Lips DJ (2013) “Benign” superior vena cava syndrome. Intensive Care Med 39:572–573. doi:10.1007/s00134-013-2855-6
De Meerleer G, Khoo V, Escudier B, Joniau S, Bossi A, Ost P, Briganti A, Fonteyne V, Van Vulpen M, Lumen N, Spahn M, Mareel M (2014) Radiotherapy for renal-cell carcinoma. Lancet Oncol 15:e170–e177. doi:10.1016/s1470-2045(13)70569-2
De Ruysscher D, Mark Lodge M, Jones B, Brada M, Munro A, Jefferson T, Pijls-Johannesma M (2012) Charged particles in radiotherapy: a 5-year update of a systematic review. Radiother Oncol 103:5–7. doi:10.1016/j.radonc.2012.01.003
Devita V (1997) Cancer: principles and practice of oncology. Lippincott Williams & Wilkins, Philadelphia. ISBN 13: 9780397515738
Din OS, Harden SV, Hudson E, Mohammed N, Pemberton LS, Lester JF, Biswas D, Magee L, Tufail A, Carruthers R, Sheikh G, Gilligan D, Hatton MQ (2013) Accelerated hypo-fractionated radiotherapy for non small cell lung cancer: results from 4 UK centres. Radiother Oncol 109:8–12. doi:10.1016/j.radonc.2013.07.014
Egelmeers A, Goor C, van Meerbeeck J, van den Weyngaert D, Scalliet P (1996) Palliative effectiveness of radiation therapy in the treatment of superior vena cava syndrome. Bull Cancer Radiother 83:153–157
Eren S, Karaman A, Okur A (2006) The superior vena cava syndrome caused by malignant disease. Imaging with multi-detector row CT. Eur J Radiol 59:93–103. doi:10.1016/j.ejrad.2006.01.003
Fagedet D, Thony F, Timsit JF, Rodiere M, Monnin-Bares V, Ferretti GR, Vesin A, Moro-Sibilot D (2013) Endovascular treatment of malignant superior vena cava syndrome: results and predictive factors of clinical efficacy. Cardiovasc Intervent Radiol 36:140–149. doi:10.1007/s00270-011-0310-z
Funakoshi T, Latif A, Galsky MD (2014) Safety and efficacy of addition of VEGFR and EGFR-family oral small-molecule tyrosine kinase inhibitors to cytotoxic chemotherapy in solid cancers: a systematic review and meta-analysis of randomized controlled trials. Cancer Treat Rev 40:636–647. doi:10.1016/j.ctrv.2014.02.004
Gauden SJ (1993) Superior vena cava syndrome induced by bronchogenic carcinoma: is this an oncological emergency? Australas Radiol 37:363–366
Gray BH, Olin JW, Graor RA, Young JR, Bartholomew JR, Ruschhaupt WF (1991) Safety and efficacy of thrombolytic therapy for superior vena cava syndrome. Chest 99:54–59
Gwon DI, Ko GY, Kim JH, Shin JH, Yoon HK, Sung KB (2013) Malignant superior vena cava syndrome: a comparative cohort study of treatment with covered stents versus uncovered stents. Radiology 266:979–987. doi:10.1148/radiol.12120517
Hamzik J, Chudej J, Dzian A, Sokol J, Kubisz P (2015) Endovascular stenting in malignant obstruction of superior vena cava. Int J Surg Case Rep 13:84–87. doi:10.1016/j.ijscr.2015.06.017
Hennequin LM, Fade O, Fays JG, Bic JF, Jaafar S, Bertal A, Anthoine D, Bernadac PA (1995) Superior vena cava stent placement: results with the Wallstent endoprosthesis. Radiology 196:353–361. doi:10.1148/radiology.196.2.7617844
Hohloch K, Bertram N, Trumper L, Beissbarth T, Griesinger F (2014) Superior vena cava syndrome caused by a malignant tumor: a retrospective single-center analysis of 124 cases. J Cancer Res Clin Oncol. doi:10.1007/s00432-014-1764-6
Hunter W, Johnston W (1757) The history of an aneurysm of the aorta, with some remarks on aneurysms in general. Medical observations and inquiries, vol 1. William Johnston, London
Khan UA, Shanholtz CB, McCurdy MT (2014) Oncologic mechanical emergencies. Emerg Med Clin N Am 32:495–508. doi:10.1016/j.emc.2014.04.001
Kim HJ, Kim HS, Chung SH (1993) CT diagnosis of superior vena cava syndrome: importance of collateral vessels. AJR Am J Roentgenol 161:539–542. doi:10.2214/ajr.161.3.8352099
Kishi K, Sonomura T, Mitsuzane K, Nishida N, Yang RJ, Nomura S, Satoh M, Yamada R, Kobayashi H, Juri M et al (1992) Expandable metallic stent therapy for SVC syndrome-effects on local venous pressure, vascular diameter, symptoms, and these correlations. Nihon Igaku Hoshasen Gakkai Zasshi 52:1661–1670
Kishi K, Sonomura T, Mitsuzane K, Nishida N, Yang RJ, Sato M, Yamada R, Shirai S, Kobayashi H (1993) Self-expandable metallic stent therapy for superior vena cava syndrome: clinical observations. Radiology 189:531–535. doi:10.1148/radiology.189.2.8210386
Koetters KT (2012) Superior vena cava syndrome. J Emerg Nurs 38:135–138x. doi:10.1016/j.jen.2010.08.019 (quiz 199)
Komoda S, Komoda T, Knosalla C, Pavel ME, Morawietz L, von Weikersthal LF, Lehmkuhl HB, Hetzer R (2012) A giant neuroendocrine tumor of the thymus gland causing superior vena cava syndrome. Gen Thorac Cardiovasc Surg 60:863–867. doi:10.1007/s11748-012-0104-5
Kvale PA, Selecky PA, Prakash UBS (2007) Palliative care in lung cancer*: Accp evidence-based clinical practice guidelines (2nd edition). Chest 132:368S–403S. doi:10.1378/chest.07-1391
Lacombe J, Mange A, Azria D, Solassol J (2013) Identification of predictive biomarkers to radiotherapy outcome through proteomics approaches. Cancer Radiother. 17:62–69. doi:10.1016/j.canrad.2012.11.003 quiz 70, 72
Lacout A, Marcy PY, Thariat J, Lacombe P, El Hajjam M (2012) Radio-anatomy of the superior vena cava syndrome and therapeutic orientations. Diagn Interv Imaging 93:569–577. doi:10.1016/j.diii.2012.03.025
Lanciego C, Pangua C, Chacon JI, Velasco J, Boy RC, Viana A, Cerezo S, Garcia LG (2009) Endovascular stenting as the first step in the overall management of malignant superior vena cava syndrome. AJR Am J Roentgenol 193:549–558. doi:10.2214/ajr.08.1904
Lonardi F, Gioga G, Agus G, Coeli M, Campostrini F (2002) Double-flash, large-fraction radiation therapy as palliative treatment of malignant superior vena cava syndrome in the elderly. Support Care Cancer 10:156–160. doi:10.1007/s00520-001-0313-4
Maki RG, Awan RA, Dixon RH, Jhanwar S, Antonescu CR (2002) Differential sensitivity to imatinib of 2 patients with metastatic sarcoma arising from dermatofibrosarcoma protuberans. Int J Cancer 100:623–626
Maleux G, Gillardin P, Fieuws S, Heye S, Vaninbroukx J, Nackaerts K (2013) Large-bore nitinol stents for malignant superior vena cava syndrome: factors influencing outcome. AJR Am J Roentgenol 201:667–674. doi:10.2214/ajr.12.9582
Marcy P-Y, Magne N, Bentolila F, Drouillard J, Bruneton J-N, Descamps B (2001) Superior vena cava obstruction: is stenting necessary? Support Care Cancer 9:103–107
Martin M, Baumgartner I, Kolb M, Triller J, Dinkel HP (2002) Fatal pericardial tamponade after Wallstent implantation for malignant superior vena cava syndrome. Journal Endovasc Ther 9:680–684. doi:10.1583/1545-1550(2002)009<0680:fptawi>2.0.co;2
McKenzie JT, McTyre E, Kunaprayoon D, Redmond KP (2013) Stereotactic body radiotherapy for superior vena cava syndrome. Rep Pract Oncol Radiother 18:179–181. doi:10.1016/j.rpor.2012.12.003
Mineo TC, Ambrogi V, Nofroni I, Pistolese C (1999) Mediastinoscopy in superior vena cava obstruction: analysis of 80 consecutive patients. Ann Thorac Surg 68:223–226
Mitin T, Zietman AL (2014) Promise and pitfalls of heavy-particle therapy. J Clin Oncol 32:2855–2863. doi:10.1200/jco.2014.55.1945
Mose S, Stabik C, Eberlein K, Ramm U, Bottcher HD, Budischewski K (2006) Retrospective analysis of the superior vena cava syndrome in irradiated cancer patients. Anticancer Res 26:4933–4936
Nagata T, Makutani S, Uchida H, Kichikawa K, Maeda M, Yoshioka T, Anai H, Sakaguchi H, Yoshimura H (2007) Follow-up results of 71 patients undergoing metallic stent placement for the treatment of a malignant obstruction of the superior vena cava. Cardiovasc Intervent Radiol 30:959–967. doi:10.1007/s00270-007-9088-4
Nicholson AA, Ettles DF, Arnold A, Greenstone M, Dyet JF (1997) Treatment of malignant superior vena cava obstruction: metal stents or radiation therapy. J Vasc Interv Radiol 8:781–788
Nogeire C, Mincer F, Botstein C (1979) Long survival in patients with bronchogenic carcinoma complicated by superior vena caval obstruction. Chest 75:325–329. doi:10.1378/chest.75.3.325
Olsen DR, Bruland ØS, Frykholm G, Norderhaug IN (2007) Proton therapy: a systematic review of clinical effectiveness. Radiother Oncol 83:123–132. doi:10.1016/j.radonc.2007.03.001
Ostler PJ, Clarke DP, Watkinson AF, Gaze MN (1997) Superior vena cava obstruction: a modern management strategy. Clin oncol (R Coll Radiol) 9:83–89
Parish JM, Marschke RF Jr, Dines DE, Lee RE (1981) Etiologic considerations in superior vena cava syndrome. Mayo Clin Proc 56:407–413
Percarpio B, Gray S (1979) Prolonged survival following the superior vena cava syndrome. Chest J 75:639–640
Pereira JR, Martins SJ, Ikari FK, Nikaedo SM, Gampel O (1999) Neoadjuvant chemotherapy vs. radiotherapy alone for superior vena cava syndrome (SVCS) due to non-small cell lung cancer (NSCLC): preliminary results of randomized phase II trial. Eur J Cancer 35(Supplement 4):S260. doi:10.1016/S0959-8049(99)81452-X
Perez C, Brady L, Waver D, Freeman C (2007) Perez and Brady’s principles and practice of radiation oncology, 5th edn. Lipincott Williams & Wilkin, Philadelphia. ISBN-13: 9780781763691
Rachapalli V, Boucher LM (2014) Superior vena cava syndrome: role of the interventionalist. Can Assoc Radiol J. 65:168–176. doi:10.1016/j.carj.2012.09.003
Rice TW, Rodriguez RM, Light RW (2006a) The superior vena cava syndrome: clinical characteristics and evolving etiology. Medicine 85:37–42. doi:10.1097/01.md.0000198474.99876.f0
Rice TW, Rodriguez RM, Barnette R, Light RW (2006b) Prevalence and characteristics of pleural effusions in superior vena cava syndrome. Respirology 11:299–305. doi:10.1111/j.1440-1843.2006.00841.x
Rizvi AZ, Kalra M, Bjarnason H, Bower TC, Schleck C, Gloviczki P (2008) Benign superior vena cava syndrome: stenting is now the first line of treatment. J Vasc Surg 47:372–380. doi:10.1016/j.jvs.2007.09.071
Robinson C, Stephans K, Reddy C, Djemil T, Videtic G (2009) Stereotactic body radiotherapy (SBRT) for radiographically diagnosed primary lung cancer without histologic confirmation. Int J Radiat Oncol Biol Phys 75:S453–S454. doi:10.1016/j.ijrobp.2009.07.1037
Rodrigues CI, Njo KH, Karim AB (1993) Hypofractionated radiation therapy in the treatment of superior vena cava syndrome. Lung cancer. 10:221–228
Rosch J, Uchida BT, Hall LD, Antonovic R, Petersen BD, Ivancev K, Barton RE, Keller FS (1992) Gianturco-Rosch expandable Z-stents in the treatment of superior vena cava syndrome. Cardiovasc Intervent Radiol 15:319–327
Rowell NP, Gleeson FV (2001) Steroids, radiotherapy, chemotherapy and stents for superior vena caval obstruction in carcinoma of the bronchus. Cochrane Database Syst Rev. doi:10.1002/14651858.cd001316
Schechter MM (1954) The superior vena cava syndrome. Am J Med Sci 227:46–56
Schraufnagel DE, Hill R, Leech JA, Pare JA (1981) Superior vena caval obstruction. Is it a medical emergency? Am J Med 70:1169–1174
Sculier JP, Evans WK, Feld R, Deboer G, Payne DG, Shepherd FA, Pringle JF, Yeoh JL, Quirt IC, Curtis JE, Herman JG (1986) Superior vena caval obstruction syndrome in small cell lung cancer. Cancer 57:847–851. doi:10.1002/1097-0142(19860215)57:4<847:AID-CNCR2820570427>3.0.CO;2-H
Sofue K, Takeuchi Y, Arai Y, Sugimura K (2013) Life-threatening cerebral edema caused by acute occlusion of a superior vena cava stent. Cardiovasc Intervent Radiol 36:272–275. doi:10.1007/s00270-012-0421-1
Spiro SG, Shah S, Harper PG, Tobias JS, Geddes DM, Souhami RL (1983) Treatment of obstruction of the superior vena cava by combination chemotherapy with and without irradiation in small-cell carcinoma of the bronchus. Thorax 38:501–505. doi:10.1136/thx.38.7.501
Stanford W, Jolles H, Ell S, Chiu LC (1987) Superior vena cava obstruction: a venographic classification. AJR Am J Roentgenol 148:259–262. doi:10.2214/ajr.148.2.259
Sugawara K, Mizumoto M, Numajiri H, Ohno T, Ohnishi K, Ishikawa H, Okumura T, Sakurai H (2014) Proton beam therapy for a patient with a giant thymic carcinoid tumor and severe superior vena cava syndrome. Rare Tumors 6(2). doi:10.4081/rt.2014.5177
Sundstrøm S, Bremnes R, Aasebø U, Aamdal S, Hatlevoll R, Brunsvig P, Johannessen DC, Klepp O, Fayers PM, Kaasa S (2004) Hypofractionated palliative radiotherapy (17 Gy per two fractions) in advanced non-small-cell lung carcinoma is comparable to standard fractionation for symptom control and survival: a National Phase III Trial. J Clin Oncol 22:801–810. doi:10.1200/jco.2004.06.123
Taguchi J, Kinoshita I, Akita H (2011) Gan to kagaku ryoho [Superior vena cava syndrome]. Cancer Chemother 38:518–523
Tanigawa N, Sawada S, Mishima K, Okuda Y, Mizukawa K, Ohmura N, Toita T, Ogawa K, Kobayashi M, Kobayashi M (1998) Clinical outcome of stenting in superior vena cava syndrome associated with malignant tumors. Comparison with conventional treatment. Acta Radiol. 39:669–674
Timmerman RD, Kavanagh BD, Cho LC, Papiez L, Xing L (2007) Stereotactic body radiation therapy in multiple organ sites. J Clin Oncol 25:947–952. doi:10.1200/jco.2006.09.7469
Timmerman R, Paulus R, Galvin J, Michalski J, Straube W, Bradley J, Fakiris A, Bezjak A, Videtic G, Johnstone D, Fowler J, Gore E, Choy H (2010) Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA J Am Med Assoc 303:1070–1076. doi:10.1001/jama.2010.261
Timmerman RD, Herman J, Cho LC (2014) Emergence of stereotactic body radiation therapy and its impact on current and future clinical practice. J Clin Oncol 32:2847–2854. doi:10.1200/jco.2014.55.4675
Trigaux JP, Van Beers B (1990) Thoracic collateral venous channels: normal and pathologic CT findings. J Comput Assist Tomogr 14:769–773
Uberoi R (2006) Quality assurance guidelines for superior vena cava stenting in malignant disease. Cardiovasc Intervent Radiol 29:319–322. doi:10.1007/s00270-005-0284-9
Wan JF, Bezjak A (2010) Superior vena cava syndrome. Hematol Oncol Clin N Am 24:501–513. doi:10.1016/j.hoc.2010.03.003
Watkinson AF, Yeow TN, Fraser C (2008) Endovascular stenting to treat obstruction of the superior vena cava. BMJ (Clinical research ed) 336:1434–1437. doi:10.1136/bmj.39562.512789.80
Willers H, Azzoli CG, Santivasi WL, Xia F (2013) Basic mechanisms of therapeutic resistance to radiation and chemotherapy in lung cancer. Cancer J. 19:200–207. doi:10.1097/PPO.0b013e318292e4e3
Wilson LD, Detterbeck FC, Yahalom J (2007a) Superior Vena Cava Syndrome with malignant causes. N Engl J Med 356:1862–1869. doi:10.1056/NEJMcp067190
Wilson P, Bezjak A, Asch M, Barton R, Wong R, Levin W, Kane G, Kirkbride P (2007b) The difficulties of a randomized study in superior vena caval obstruction. J Thorac Oncol 2:514–519. doi:10.1097/JTO.0b013e318060096b
Yamagami T, Nakamura T, Kato T, Iida S, Nishimura T (2002) Hemodynamic changes after self-expandable metallic stent therapy for vena cava syndrome. AJR Am J Roentgenol 178:635–639. doi:10.2214/ajr.178.3.1780635
Yellin A, Rosen A, Reichert N, Lieberman Y (1990) Superior vena cava syndrome. The myth–the facts. Am Rev Respir Dis 141:1114–1118. doi:10.1164/ajrccm/141.5_Pt_1.1114
Yu JB, Wilson LD, Detterbeck FC (2008) Superior Vena Cava Syndrome: a proposed classification system and algorithm for management. J Thorac Oncol 3(811–814):8. doi:10.1097/JTO.1090b1013e3181804791