Review of Whole Plant Extracts With Activity Against Herpes Simplex Viruses In Vitro and In Vivo

Anna Garber1, Lianna Barnard1, Chris Pickrell1
1Department of Research, Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada

Tóm tắt

Herpes simplex viruses, HSV-1 and HSV-2, are highly contagious and cause lifelong, latent infections with recurrent outbreaks of oral and/or genital lesions. No cure exists for HSV-1 or HSV-2 infections, but antiviral medications are commonly used to prevent and treat outbreaks. Resistance to antivirals has begun to emerge, placing an importance on finding new and effective therapies for prophylaxis and treatment of HSV outbreaks. Botanicals may be effective HSV therapies as the constituents they contain act through a variety of mechanisms, potentially making the development of antiviral resistance more challenging. A wide variety of plants from different regions in the world have been studied for antiviral activity against HSV-1 and/or HSV-2 and showed efficacy of varying degrees. The purpose of this review is to summarize research conducted on whole plant extracts against HSV-1 and/or HSV-2 in vitro and in vivo. The majority of the research reviewed was conducted in vitro using animal cell lines, and some studies used an animal model design. Also summarized are a limited number of human trials conducted using botanical therapies on HSV lesions.

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Tài liệu tham khảo

10.1016/j.vaccine.2015.12.076

10.1016/S0140-6736(00)04638-9

10.5604/12321966.1152063

10.3390/ijms19103266

Opstelten W, 2008, Can Fam Physician, 54, 1683

10.3390/v11050463

World Health Organization. Herpes simplex virus. World Health Organization. Accessed July 6, 2019. https://www.who.int/news-room/fact-sheets/detail/herpes-simplex-virus#hsv1

10.1056/NEJMcp023065

10.3233/JAD-140822

10.1684/ejd.2013.2072

10.1258/0956462011923859

10.1038/ijos.2016.3

Chi CC, 2015, Cochrane Database Syst Rev, 2015, CD010095

Le Cleach L, 2014, Cochrane Database Syst Rev, CD009036

Heslop R, 2016, Cochrane Database Syst Rev, CD010684

Hammer KDP, 2018, EMJ Dermatol, 6, 118, 10.33590/emjdermatol/10311121

10.1016/0166-3542(95)00010-J

10.1016/0030-4220(78)90223-2

Lopez BS, 2009, In Vivo, 23, 1011

Mailoo VJ, 2017, Integr Med (Encinitas), 16, 42

Singh BB, 2005, Altern Med Rev, 10, 123

10.1159/000250926

10.1111/jphp.12436

10.1016/j.micres.2012.11.002

Garcia CC, 2010, Nat Prod Commun, 5, 1307

Faral-Tello P, 2012, Sci World J, 2012

10.1016/S0378-8741(01)00292-6

10.1016/S0166-3542(03)00152-9

10.1002/ptr.1518

10.5897/AJB2007.000-2276

Montanha JA, 2004, Acta Farm Bonaerense, 23, 183

10.1002/ptr.1305

10.1016/0166-3542(93)90094-Y

Abdul AM, 1996, Pertanika J Trop Agric Sci, 19, 129

10.1016/S0378-8741(99)00049-5

10.1016/0378-8741(96)01409-2

10.1111/j.1472-765X.2010.02924.x

10.1016/S0378-8741(98)00013-0

10.3851/IMP2988

10.1142/S0192415X03001582

10.1016/j.fitote.2005.03.010

10.1016/j.biopha.2017.07.116

10.1248/bpb.26.1600

10.1055/a-1087-8303

10.1002/ptr.2650070606

10.3109/13880200903468873

10.1007/s12250-014-3486-y

10.1016/j.antiviral.2013.01.001

10.1002/ptr.3085

10.1080/14786419.2017.1354186

10.1016/S0306-3623(98)00214-6

10.1002/(SICI)1099-1573(199903)13:2<142::AID-PTR392>3.0.CO;2-7

10.1016/S0378-8741(99)00008-2

10.1142/S0192415X04002284

Santoyo S, 2012, J Food Nutr Res, 51, 225

10.1002/ptr.1858

10.1093/jac/dkg291

10.1159/000263619

Farahani M., 2014, Appl Environ Microbiol, 2, 102

10.1016/j.jep.2012.07.016

10.1016/j.jep.2009.08.001

10.1016/j.jep.2005.08.053

10.1080/14786419.2017.1423300

10.3109/13880209.2011.643902

10.1016/j.phymed.2007.03.013

10.1016/S0944-7113(00)80068-9

10.1002/ptr.1458

10.1016/0378-8741(94)90103-1

10.1590/S0102-695X2012005000061

10.1016/S0367-326X(02)00080-1

10.1016/S2221-1691(13)60064-7

10.1016/0166-3542(93)90010-G

10.1016/j.jep.2017.08.010

10.1055/s-2006-961006

10.1186/s12906-017-1618-2

Vijayan P, 2004, Indian J Med Res, 120, 24

Zandi K, 2007, Afr J Biotechnol, 66, 2511

10.1007/s10811-011-9692-1

10.1055/s-2002-34397

10.1055/s-0029-1186137

10.1248/bpb.28.2258

10.1016/S0367-326X(02)00125-9

10.3390/v7010352

10.1080/14786410701589790

10.1177/095632020401500305

10.1002/cbdv.201900511

Schnitzler P, 2001, Pharmazie, 56, 343

10.1002/ptr.2226

10.1590/S0074-02762002000400017

10.4314/tjpr.v15i4.13

10.1111/j.1440-1681.2005.04194.x

10.1002/(SICI)1099-1573(199902)13:1<37::AID-PTR382>3.0.CO;2-S

10.1016/j.nbt.2009.08.005

10.1080/14786419.2010.528758

10.1007/s00705-016-3032-3

10.1016/j.jep.2013.09.005

10.1016/S0378-8741(98)00095-6

10.1016/0166-3542(94)00076-K

10.1016/S0923-1811(96)00555-5

Ghannad MS, 2014, Jundishapur J Microbiol, 7, e11616

10.21873/invivo.10994

10.1080/13102818.2019.1656108

10.1016/0378-8741(96)01387-6

Bonvicini F, 2018, New Microbiol, 41, 187

10.1055/s-2006-958063

10.1016/j.antiviral.2011.09.005

10.1371/journal.pone.0115475

10.1002/ptr.2198

10.1002/ptr.3590

Kaushik NK, 2015, Int J Adv Res, 3, 1365

10.1615/IntJMedMushr.v15.i1.40

10.1016/0166-3542(93)90073-R

10.1055/s-2005-873175

10.1078/094471102321616463

10.1016/S0378-8741(98)00098-1

10.1016/j.antiviral.2008.06.009

10.1016/S0764-4469(98)80461-7

10.1142/S0192415X01000472

10.1002/ptr.1348

Dimitrova Z, 1993, Acta Microbiol Bulg, 29, 65

10.1055/s-2006-951719

10.1016/j.phymed.2008.04.018

10.1080/14786410802075939

10.1159/000335590

10.21859/isv.8.1.35

Reichling J, 2008, Forsch Komplementmed, 15, 313

10.1078/094471103322331467

10.1016/j.phymed.2014.01.013

10.1186/1472-6882-13-266

10.1007/s11373-005-9001-6

10.1111/j.1440-1681.2005.04270.x

10.1159/000092859

10.1016/0166-3542(95)00839-X

10.1371/journal.pone.0139338

10.1016/j.micpath.2017.12.017

10.1016/j.phymed.2008.06.009

10.1142/S0192415X09006655

10.7150/ijms.6902

10.1016/S0378-8741(00)00228-2

10.1002/ptr.1300

10.1016/j.antiviral.2005.02.008

10.1016/j.micres.2004.11.002

10.1142/S0192415X03000874

10.1016/S0166-3542(02)00007-4

10.1515/znc-2000-9-1026

10.1099/00222615-38-4-262

10.1016/S0166-3542(01)00141-3

10.1177/2156587216676421

10.1016/j.fitote.2010.11.022

Reichling J, 2009, Pharmazie, 64, 538

10.1016/S0166-3542(98)00023-0

10.1016/j.tripleo.2011.04.007

10.1016/j.phymed.2007.11.013

10.1002/ptr.1207

Sakagami H, 2016, In Vivo, 30, 421

Nocchi SR, 2017, Planta Med, 83, 509

10.1515/znc-2009-11-1210

10.1111/jam.13729

10.1002/ptr.881

10.1111/jam.13279

10.4103/0255-0857.43561

10.1016/j.phymed.2018.06.040

10.1002/ptr.2638

Alvarez AL, 2011, Phytother Res, 25, 296, 10.1002/ptr.3382

10.1186/s12906-017-1620-8

10.1002/ptr.6084

10.2174/1389201016666150505125235

Cella M, 2004, Rev Argent Microbiol, 36, 136

10.1016/j.jep.2017.11.039

10.14715/cmb/2018.64.8.2

10.1142/S0192415X10007749

10.1078/S0944-7113(04)70069-0

10.3923/pjbs.2013.180.184

10.1002/ptr.2650040305

10.1007/BF01920746

10.1016/0192-0561(94)90059-0

10.1002/jmv.1890460107

10.1016/j.antiviral.2007.08.012

10.1159/000119705

10.3390/v10110580

10.1093/jac/48.3.450

10.1016/S0944-7113(11)80019-X

10.1016/S0944-7113(99)80013-0

Clewell A, 2012, J Drugs Dermatol, 11, 209

10.1023/A:1008049117811

10.1089/acm.2006.6297

Saller R, 2001, Forsch Komplementarmed Klass Naturheilkd, 8, 373

10.3390/molecules22050722

10.1142/S0192415X03001090

10.1016/j.jep.2004.05.004

10.3851/IMP3118

10.1002/(SICI)1099-1573(199906)13:4<355::AID-PTR454>3.0.CO;2-E

10.1055/s-1999-14061

10.1258/0956462011916947