Review article: bifidobacteria as probiotic agents – physiological effects and clinical benefits
Tóm tắt
Bifidobacteria, naturally present in the dominant colonic microbiota, represent up to 25% of the cultivable faecal bacteria in adults and 80% in infants. As probiotic agents, bifidobacteria have been studied for their efficacy in the prevention and treatment of a broad spectrum of animal and/or human gastrointestinal disorders, such as colonic transit disorders, intestinal infections, and colonic adenomas and cancer. The aim of this review is to focus on the gastrointestinal effects of bifidobacteria as probiotic agents in animal models and man. The traditional use of bifidobacteria in fermented dairy products and the GRAS (‘Generally Recognised As Safe’) status of certain strains attest to their safety. Some strains, especially
Từ khóa
Tài liệu tham khảo
Blaut M, 2002, Molecular biological methods for studying the gut microbiota: the EU human gut flora project, Br J Nutr, 87, S203, 10.1079/BJN/2002539
Yoshioka H, 1983, Development and differences of intestinal flora in the neonatal period in breast‐fed and bottle‐fed infants, Pediatrics, 72, 317, 10.1542/peds.72.3.317
European commission (Health and Consumer protection directorate‐general), Qualified Presumption of Safety. On a Generic Approach to the Safety Assessment of micro‐organisms Used in Feed/food and Feed/food Production
FAO/WHO, 2001, Report of a Joint FAO/WHO Expert Group. Health and Nutritional Properties of Probiotics in Food Including Powder milk with Live Lactic Acid Bacteria
Marteau P, 1992, Survival of Lactobacillus acidophilus and Bifidobacterium sp. in the small intestine following ingestion in fermented milk. A rational basis for the use of probiotics in man, Gastroenterol Clin Biol, 16, 25
Boffa LC, 1992, Modulation of colonic epithelial cell proliferation, histone acetylation, and luminal short chain fatty acids by variation of dietary fiber (wheat bran) in rats, Cancer Res, 52, 5906
Cummings JH, 1995, Human Colonic Bacteria: Role in Nutrition, Physiology and Pathology, 101
Krause LJ, 1996, Feeding human milk to rats increases Bifidobacterium in the cecum and colon which correlates with enhanced folate status, J Nutr, 126, 1505, 10.1093/jn/126.5.1505
Yamazaki S, 1985, Immunological responses to monoassociated Bifidobacterium longum and their relation to prevention of bacterial invasion, Immunology, 56, 43
Ouwehand A, 2002, The role of the intestinal microflora for the development of the immune system in early childhood, Eur J Nutr, 41, I32
Roos NM, 2000, Effects of probiotic bacteria on diarrhea, lipid metabolism, and carcinogenesis: a review of papers published between 1988 and 1998, Am J Clin Nutr, 71, 405, 10.1093/ajcn/71.2.405
Moreau MC, 1998, Functional Foods: The Consumer, the Products and the Evidence, 47
Moreau MC, 1998, International Congress of Immunology, 407
Phuapradit P, 1999, Reduction of rotavirus infection in children receiving bifidobacteria‐supplemented formula, J Med Assoc Thai, 82, S43
Plummer S, 2004, Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea, Int Microbiol, 7, 59
Ling WH, 1994, Lactobacillus strain GG supplementation decreases colonic hydrolytic and reductive enzyme activities in healthy female adults, J Nutr, 124, 18, 10.1093/jn/124.1.18
Pedrosa MC, 1995, Survival of yogurt‐containing organisms and Lactobacillus gasseri (ADH) and their effect on bacterial enzyme activity in the gastrointestinal tract of healthy and hypochlorhydric elderly subjects, Am J Clin Nutr, 61, 353, 10.1093/ajcn/61.2.353
Rowland IR, 1975, Degradation of N‐nitrosamines by intestinal bacteria, Appl Microbiol, 29, 7, 10.1128/am.29.1.7-12.1975
Bouhnik Y, 1996, Effects of Bifidobacterium sp fermented milk ingested with or without inulin on colonic bifidobacteria and enzymatic activities in healthy humans, Eur J Clin Nutr, 50, 269
Andrieux CM, 2002, Metabolic characteristics of the faecal microflora in humans from three age groups, Scand J Gastroenterol, 37, 792, 10.1080/gas.37.7.792.798
Ayanaba A, 1973, Microbial formation of nitrosamines in vitro, Appl Microbiol, 25, 862, 10.1128/am.25.6.862-868.1973
Roncucci L, 1992, Early events in human colorectal carcinogenesis. Aberrant crypts and microadenoma, Ital J Gastroenterol, 24, 498
Reddy BS, 1993, Inhibitory effect of Bifidobacterium longum on colon, mammary, and liver carcinogenesis induced by 2‐amino‐3‐methylimidazo[4,5‐f]quinoline, a food mutagen, Cancer Res, 53, 3914