Reversed-phase chiral liquid chromatography on polysaccharide-based stationary phase coupled with tandem mass spectrometry for simultaneous determination of four stereoisomers of MK-0974 in human plasma

Yang Xu1, Donald G. Musson1
1Merck Research Laboratories, Department of Drug Metabolism and Pharmacokinetics, WP75A-303, West Point, PA 19486, USA

Tài liệu tham khảo

Richards, 1997, Chem. Ind. Mislanova, 2003, J. Chromtogr. B, 797, 91, 10.1016/j.jchromb.2003.07.018 C.S. Burgey, Z.J. Deng, D.N. Ngugen, D.V. Paone, A.W. Shaw, T.M. Williams, The United State Patent and Trademark Office (USPTO) October 11, US Patent number 6,953,790 (2005). Ho, 2007, Neurology Xu, 2008, J. Chromatogr. B, 863, 64, 10.1016/j.jchromb.2007.12.017 Mislanova, 2003, J. Chromatogr. B, 797, 91, 10.1016/j.jchromb.2003.07.018 Maftouh, 2005, J. Chromatogr. A, 1088, 67, 10.1016/j.chroma.2004.12.038 Perrin, 2002, J. Chromatogr. A, 966, 119, 10.1016/S0021-9673(02)00746-X Cirilli, 2006, J. Chromatogr. A, 1101, 198, 10.1016/j.chroma.2005.10.003 Zagrobelny, 1998, J. Pharm. Biomed. Anal., 17, 1057, 10.1016/S0731-7085(98)00071-5 Lipka, 2004, J. Chromatogr. A, 1034, 161, 10.1016/j.chroma.2004.02.021 Lipka, 2005, J. Biochem. Biophys. Methods, 64, 46, 10.1016/j.jbbm.2005.05.008 Desai, 2004, J. Chromatogr. A, 1035, 203, 10.1016/j.chroma.2004.02.057 Petritis, 2001, J. Chromatogr. A, 913, 331, 10.1016/S0021-9673(00)01268-1 Basakova, 2002, J. Chromatogr. B, 770, 63, 10.1016/S0378-4347(01)00559-X Yashima, 2001, J. Chromatogr. A, 906, 105, 10.1016/S0021-9673(00)00501-X Food and Drug Administration, US Department of Health and Human Services, Guidance for Industry: Safety Testing of Drug Metabolites, February 2008.