Retrospective mining of toxicology data to discover multispecies and chemical class effects: Anemia as a case study

Aziz, 2014, Alterations of blood indices associated with low-dose administration of methomyl insecticide for short times to albino rats, Egypt. J. Biol., 16, 17, 10.4314/ejb.v16i1.2 Badawi, 2009, Metabolites of the phenylurea herbicides chlorotoluron, diuron, isoproturon and linuron produced by the soil fungus Mortierella sp, Environ. Pollut., 157, 2806, 10.1016/j.envpol.2009.04.019 Bailey, 2014, An analysis of the use of animal models in predicting human toxicology and drug safety, Altern. Lab. Anim., 42, 181, 10.1177/026119291404200306 Barr, 2007, Identification of human urinary metabolites of acetochlor in exposed herbicide applicators by high-performance liquid chromatography-tandem mass spectrometry, J. Expo. Sci. Environ. Epidemiol., 17, 559, 10.1038/sj.jes.7500583 Bhardwaj, 2014, Elimination of young erythrocytes from blood circulation and altered erythropoietic patterns during paraquat induced anemic phase in mice, PLoS One, 9, e99364, 10.1371/journal.pone.0099364 Bitsch, 2006, REPDOSE: a database on repeated dose toxicity studies of commercial chemicals–A multifunctional tool, Regul. Toxicol. Pharmacol., 46, 202, 10.1016/j.yrtph.2006.05.013 Braun, 2006, Life-threatening intoxication with methylene bis(thiocyanate): clinical picture and pitfalls. A case report, BMC Emerg. Med., 6, 5, 10.1186/1471-227X-6-5 Burka, 1993, NTP technical report on the toxicity studies of methylene bis(thiocyanate) (CAS No. 6317-18-6) administered by gavage to F344/N rats and B6C3F1 mice, Toxic. Rep. Ser., 32, 1 Bus, 1987, Perspectives on the mechanism of action of the splenic toxicity of aniline and structurally-related compounds, Food Chem. Toxicol., 25, 619, 10.1016/0278-6915(87)90024-X Busschers, 2013, vol. 2013, 499 Cabagna, 2005, Hematological parameters of health status in the common toad Bufo arenarum in agroecosystems of Santa Fe Province, Argentina, Appl. Herpetol., 2, 373, 10.1163/157075405774483085 Cheng, 2004, Arsenic inhibition of the JAK-STAT pathway, Oncogene, 23, 3603, 10.1038/sj.onc.1207466 Chow, 1975, Propanil (3,4-dichloropropionanilide)-induced methemoglobin formation in relation to its metabolism in vitro, Toxicol. Appl. Pharmacol., 33, 14, 10.1016/0041-008X(75)90238-0 Claassen, 1994 Clark, 1988, Hematological effects of ethyl methanesulfonate, paraquat and phenylhydrazine in Japanese quail, Comp. Biochem. Physiol. C, 89, 15, 10.1016/0742-8413(88)90140-5 Coller, 2015, Blood at 70: its roots in the history of hematology and its birth, Blood, 126, 2548, 10.1182/blood-2015-09-659581 COSMOS, 2016 Dorato, 2005, The no-observed-adverse-effect-level in drug safety evaluations: use, issues, and definition(s), Regul. Toxicol. Pharmacol., 42, 265, 10.1016/j.yrtph.2005.05.004 Drzyzga, 2003, Diphenylamine and derivatives in the environment: a review, Chemosphere, 53, 809, 10.1016/S0045-6535(03)00613-1 Eddleston, 2002, Severe propanil [N-(3,4-dichlorophenyl) propanamide] pesticide self-poisoning, J. Toxicol. Clin. Toxicol., 40, 847, 10.1081/CLT-120016955 Everds, 2015, Evaluation of clinical pathology data: correlating changes with other study data, Toxicol. Pathol., 43, 90, 10.1177/0192623314555340 Everds, 2013, Interpreting stress responses during routine toxicity studies: a review of the biology, impact, and assessment, Toxicol. Pathol., 41, 560, 10.1177/0192623312466452 Fisher, 1993 Fujitani, 2000, Subchronic toxicity of chlorpropham (CIPC) in ICR mice, Food Chem. Toxicol., 38, 617, 10.1016/S0278-6915(00)00043-0 Fujitani, 1997, Hemotoxicity of chlorpropham (CIPC) in F344 rats, Toxicology, 123, 111, 10.1016/S0300-483X(97)00113-3 Fujitani, 2001, Effects of chlorpropham (CIPC) on the hemopoietic system of rats, Food Chem. Toxicol., 39, 253, 10.1016/S0278-6915(00)00139-3 Fujitani, 2004, Chlorpropham-induced splenotoxicity and its recovery in rats, Food Chem. Toxicol., 42, 1469, 10.1016/j.fct.2004.04.008 Gadagbui, 2010, Derived Reference Doses (RfDs) for the environmental degradates of the herbicides alachlor and acetochlor: results of an independent expert panel deliberation, Regul. Toxicol. Pharmacol., 57, 220, 10.1016/j.yrtph.2010.02.010 Gomyo, 1991, Analytical method for the total content of Residues of triflumizole fungicide and its metabolites in crops by high performance liquid and gas chromatography, Anal. Sci., 7, 579, 10.2116/analsci.7.579 Hamilton, 2006 Hareng, 2005, The integrated project ReProTect: a novel approach in reproductive toxicity hazard assessment, Reprod. Toxicol., 20, 441, 10.1016/j.reprotox.2005.04.003 Haschek, 2010 Jang, 2014, Hemolytic uremic syndrome associated with paraquat intoxication, J. Clin. Apher., 29, 183, 10.1002/jca.21310 Jaworska, 2002, Probabilistic assessment of biodegradability based on metabolic pathways: catabol system, Sar. QSAR Environ. Res., 13, 307, 10.1080/10629360290002794 Jefferies, 1998, Dialkylquinonimines validated as in vivo metabolites of alachlor, acetochlor, and metolachlor herbicides in rats, Chem. Res. Toxicol., 11, 353, 10.1021/tx970209z JMPR, 2000 Jung, 2013, Clinical characteristics of patients with indoxacarb insecticide poisoning, J. Korean Soc. Emerg. Med., 24, 188 Kaushansky, 2010 Kavlock, 2012, Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management, Chem. Res. Toxicol., 25, 1287, 10.1021/tx3000939 Kawatsu, 1977, Studies on the anemia of fish-VIII. Hemorrhagic anemia of carp caused by a herbicide, molinate, NIPPON SUISAN GAKKAISHI, 43, 905, 10.2331/suisan.43.905 Kiese, 1966, The biochemical production of ferrihemoglobin-forming derivatives from aromatic amines, and mechanisms of ferrihemoglobin formation, Pharmacol. Rev., 18, 1091 Kleinstreuer, 2013, In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis, Toxicol. Sci., 131, 40, 10.1093/toxsci/kfs285 Knudsen, 2009, Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB, Reprod. Toxicol., 28, 209, 10.1016/j.reprotox.2009.03.016 Kolanczyk, 2012, MetaPath: an electronic knowledge base for collating, exchanging and analyzing case studies of xenobiotic metabolism, Regul. Toxicol. Pharmacol., 63, 84, 10.1016/j.yrtph.2012.02.013 Leet, 2014, High-content screening in zebrafish embryos identifies butafenacil as a potent inducer of anemia, PLoS One, 9, e104190, 10.1371/journal.pone.0104190 Maita, 1991, Chronic toxicity studies with thiram in Wistar rats and beagle dogs, Fundam. Appl. Toxicol., 16, 667, 10.1016/0272-0590(91)90154-V Malerba, 2002, In vitro myelotoxicity of propanil and 3,4-dichloroaniline on murine and human CFU-E/BFU-E progenitors, Toxicol. Sci., 69, 433, 10.1093/toxsci/69.2.433 Marchevsky, 2011 Martin, 2009, Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef database, Environ. Health. Perspect., 117, 392, 10.1289/ehp.0800074 Martin, 2011, Predictive model of rat reproductive toxicity from ToxCast high throughput screening, Biol. Reprod., 85, 327, 10.1095/biolreprod.111.090977 Martin, 2009, Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database, Toxicol. Sci., 110, 181, 10.1093/toxsci/kfp080 McMillan, 1991, Role of metabolites in propanil-induced hemolytic anemia, Toxicol. Appl. Pharmacol., 110, 70, 10.1016/0041-008X(91)90290-U McMillan, 1991, Contribution of 3,4-dichlorophenylhydroxylamine in propanil-induced hemolytic anemia, Adv. Exp. Med. Biol., 283, 343, 10.1007/978-1-4684-5877-0_44 Mekenyan, 2012, Simulation of Chemical Metabolism for Fate and Hazard Assessment. V. Mammalian Hazard Assessment, Sar. QSAR Environ. Res., 23, 553, 10.1080/1062936X.2012.679689 Mueller, 2005 Nakagawa, 2004, Biotransformation of chlorpropham (CIPC) in isolated rat hepatocytes and xenoestrogenic activity of CIPC and its metabolites by in vitro assays, Xenobiotica, 34, 257, 10.1080/0049825042000196767 Nakagawa, 2004, Chlorpropham induces mitochondrial dysfunction in rat hepatocytes, Toxicology, 200, 123, 10.1016/j.tox.2004.03.012 NTP, 2011 OECD, 2014 O'Mullane, 2013, vol. 2013, 219 Park, 2011, Successful treatment of methemoglobinemia and acute renal failure after indoxacarb poisoning, Clin. Toxicol. (Phila), 49, 744, 10.3109/15563650.2011.602080 Pastorelli, 1998, 3,4 Dichloroaniline-haemoglobin adducts in humans: preliminary data on agricultural workers exposed to propanil, Biomarkers, 3, 227, 10.1080/135475098231246 Piersma, 2011, Combined retrospective analysis of 498 rat multi-generation reproductive toxicity studies: on the impact of parameters related to F1 mating and F2 offspring, Reprod. Toxicol., 31, 392, 10.1016/j.reprotox.2010.11.013 Pinkhas, 1963, Sulfhemoglobinemia and acute hemolytic anemia with heinz bodies following contact with a fungicide— zinc ethylene bisdithiocarbamate—in a subject with glucose-6-phosphate dehydrogenase deficiency and hypocatalasemia, Blood, 21, 484, 10.1182/blood.V21.4.484.484 Plunkett, 2015, Challenges in using the ToxRefDB as a resource for toxicity prediction modeling, Regul. Toxicol. Pharmacol., 72, 610, 10.1016/j.yrtph.2015.05.013 Qing, 2013, Isolation and characterization of acetochlor-degrading strain Sphingomonas sp. DC-6 and preliminary studies on its metabolic pathway, J. Agric. Sci. Technol. (Beijing), 15, 67 Sabbioni, 1992, Hemoglobin binding of monocyclic aromatic amines: molecular dosimetry and quantitative structure activity relationships for the N-oxidation, Chem. Biol. Interact., 81, 91, 10.1016/0009-2797(92)90029-K Sakuratani, 2013, Hazard Evaluation Support System (HESS) for predicting repeated dose toxicity using toxicological categories, Sar. QSAR Environ. Res., 24, 351, 10.1080/1062936X.2013.773375 Sancho, 2000, Cholinesterase activity and hematological parameters as biomarkers of sublethal molinate exposure in Anguilla anguilla, Ecotoxicol. Environ. Saf., 46, 81, 10.1006/eesa.1999.1888 Santos, 2015, Toxicological evaluation of ametryn effects in Wistar rats, Exp. Toxicol. Pathol., 67, 525, 10.1016/j.etp.2015.08.001 Serafimova, 2007, Identification of the structural requirements for mutagenicity by incorporating molecular flexibility and metabolic activation of chemicals. II. General ames mutagenicity model, Chem. Res. Toxicol., 20, 662, 10.1021/tx6003369 Shih, 2011, Methemoglobinemia following ingestion of Indoxacarb: a case report, J. Acute Med., 1, 55, 10.1016/j.jacme.2011.10.005 Sipes, 2011, Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data, Toxicol. Sci., 124, 109, 10.1093/toxsci/kfr220 Tchounwou, 2003, Carcinogenic and systemic health effects associated with arsenic exposure–a critical review, Toxicol. Pathol., 31, 575 Theunissen, 2014, Toward a comparative retrospective analysis of rat and rabbit developmental toxicity studies for pharmaceutical compounds, Reprod. Toxicol., 47, 27, 10.1016/j.reprotox.2014.04.004 Thomas, 1967, Chronic toxicity of diphenylamine to albino rats, Toxicol. Appl. Pharmacol., 10, 362, 10.1016/0041-008X(67)90118-4 Thomas, 1967, The chronic toxicity of diphenylamine for dogs, Toxicol. Appl. Pharmacol., 11, 184, 10.1016/0041-008X(67)90037-3 U.S. EPA, 2008 Velisek, 2008, Effects of metribuzin on rainbow trout (Oncorhynchus mykiss), Veterinarni Med., 53, 324, 10.17221/1857-VETMED Weiss, 2005, Anemia of chronic disease, N. Engl. J. Med., 352, 1011, 10.1056/NEJMra041809 Weiss, 2002, Simultaneous determination of various aromatic amines and metabolites of aromatic nitro compounds in urine for low level exposure using gas chromatography-mass spectrometry, J. Chromatogr. B Anal. Technol. Biomed. Life Sci., 778, 179, 10.1016/S0378-4347(01)00542-4 WHO Core Assessment Group on Pesticide Residues, W. H. F, 2015 Wu, 2010, Methemoglobinemia induced by indoxacarb intoxication, Clin. Toxicol. (Phila), 48, 766, 10.3109/15563650.2010.503657 Yoshida, 1989, Twenty-eight day repeated dose toxicity testing of diphenylamine in F344 rats, Eisei Shikenjo Hokoku, 107, 56 Zhang, 2002, Arsenic speciation and distribution in an arsenic hyperaccumulating plant, Sci. Total Environ., 300, 167