Retrospective Assessment of Dobutamine Therapy for Hypotension in Anesthetized Horses
Tóm tắt
Dobutamine was infused (1.7 μg/kg/minute) into 200 anesthetized horses as treatment for hypotension. The horses had been premedicated with xylazine, and anesthesia was induced with guaifenesin and ketamine and maintained with halothane. One hundred fifty‐seven horses (79%) responded with an average increase in systolic blood pressure of at least 10 mm Hg within 10 minutes. A cardiac arrhythmia developed in 56 horses (28%) after dobutamine administration: 34 with sinus bradycardia, 18 with atrioventricular block, 2 with premature atrial contractions, and 2 with atrioventricular dissociation. Dobutamine intravenous infusion was effective treatment for hypotension in horses anesthetized with halothane.
Từ khóa
Tài liệu tham khảo
Manley SV., 1981, Veterinary Clinics of North America Symposium on Equine Anesthesia, 116
Riebold TW, 1983, Large animal anesthesia, 90
Grandy JL, 1987, Arterial hypotension and the development of postanesthetic myopathy in halothane‐anes‐thetized horses, Am J Vet Res, 48, 192
Swanson CR, 1985, Hemodynamic responses in halothane anesthetized horses given infusions of dopamine or dobutamine, Am J Vet Res, 46, 365
Liang CS, 1979, Dobutamine infusion in conscious dogs with and without autonomic nervous system inhibition: effects on systemic hemodynamics, regional blood flow and cardiac metabolism, J Pharmacol Exp Ther, 211, 698
Wetmore LA, 1987, Mixed venous oxygen tension as an estimate of cardiac output in anesthetized horses, Am J Vet Res, 48, 971
Kenakin TP., 1981, An in vitro quantitative analysis of the alpha‐receptor partial agonist activity of dobutamine and its relevance to inotropic selectivity, J Pharmacol Exp Ther, 216, 210
Muir WW, 1975, Effects of xylazine and acetylpromazine upon induced ventricular fibrillation in dogs anesthetized with thiamylal and halothane, Am J Vet Res, 36, 1299
TranquilliWJ ThurmanJC BensonGJ.Alterations in the arrhythmogenic dose of epinephrine (ADE) induced by xylazine and specific adrenergic receptor antagonists in halothane anesthetized pigs. Proceedings of the Second International Congress of Veterinary Anesthesia1985:92–3.
Muir WW, 1978, Evaluation of xylazine, guaifenesin and ketamine hydrochloride for restraint in horses, Am J Vet Res, 39, 1274
Bednarski RM, 1986, Ketamine and the arrhythmogenic dose of epinephrine in cats anesthetized with halothane and isoflurane, Am J Vet Res, 47, 2122
Purohit RC, 1981, Effects of xylazine and ketamine hydrochloride on the electroencephalogram and the electrocardiogram in the horse, Am J Vet Res, 42, 615