Retroperitoneal Castleman’s disease: advocating a multidisciplinary approach for a rare clinical entity

World Journal of Surgical Oncology - Tập 12 - Trang 1-7 - 2014
Austin D Williams1, Adriana Sanchez2, Jun Steve Hou2, Rene Rothstein Rubin3, Mark E Hysell4, Blake D Babcock1, Mohammad F Shaikh1, Michael S Weingarten5, Wilbur B Bowne1
1Division of Surgical Oncology, Department of Surgery, Drexel University College of Medicine, Philadelphia, USA
2Department of Pathology, Drexel University College of Medicine, Philadelphia, USA
3Division of Hematology/Oncology, Department of Internal Medicine, Drexel University College of Medicine, Philadelphia, USA
4Department of Diagnostic Radiology, Hahnemann University Hospital, Philadelphia, USA
5Division of Vascular Surgery, Department of Surgery, Drexel University College of Medicine, Philadelphia, USA

Tóm tắt

Castleman’s disease is a rare and poorly understood disease entity that may resemble more common conditions and represents a clinical challenge to the treating surgeon. In this report, we describe a case of a 61-year-old Caucasian woman with a symptomatic retroperitoneal mass. The specimen obtained from her resection contained a protuberant encapsulated mass, exhibiting microscopic features consistent with localized, unicentric Castleman’s disease. These characteristics included architectural features and immunohistochemical findings consistent with the hyaline vascular variant of Castleman’s disease. We report a very rare case of a retroperitoneal hyaline vascular type of Castleman’s disease. We discuss the diagnostic dilemma Castleman’s disease may present to the surgeon, with an emphasis on multidisciplinary management of these patients. We also review current data on pathogenesis, treatment and outcomes.

Tài liệu tham khảo

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