Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity

AK Abbas, 1996, Functional diversity of helper T lymphocytes., Nature, 383, 787, 10.1038/383787a0

E Bettelli, 2008, Induction and effector functions of T(H)17 cells., Nature, 453, 1051, 10.1038/nature07036

RM Anthony, 2007, Protective immune mechanisms in helminth infection., Nat Rev Immunol, 7, 975, 10.1038/nri2199

TA Wynn, 2007, Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases., J Clin Invest, 117, 524, 10.1172/JCI31487

RK Grencis, 2004, Interleukin-13: a key mediator in resistance to gastrointestinal-dwelling nematode parasites., Clin Rev Allergy Immunol, 26, 51, 10.1385/CRIAI:26:1:51

A Zhao, 2008, Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages., Gastroenterology, 135, 217, 10.1053/j.gastro.2008.03.077

FD Finkelman, 2004, Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites., Immunol Rev, 201, 139, 10.1111/j.0105-2896.2004.00192.x

EJ Pearce, 2002, The immunobiology of schistosomiasis., Nat Rev Immunol, 2, 499, 10.1038/nri843

KF Hoffmann, 2001, Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type 1 and type 2 cytokine-mediated inflammatory reactions., FASEB J, 15, 2545, 10.1096/fj.01-0306fje

P Loke, 2002, IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype., BMC Immunol, 3, 7, 10.1186/1471-2172-3-7

NG Sandler, 2003, Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair., J Immunol, 171, 3655, 10.4049/jimmunol.171.7.3655

F Shen, 2006, Identification of common transcriptional regulatory elements in interleukin-17 target genes., J Biol Chem, 281, 24138, 10.1074/jbc.M604597200

J Pesce, 2006, The IL-21 receptor augments Th2 effector function and alternative macrophage activation., J Clin Invest, 116, 2044, 10.1172/JCI27727

NG Sandler, 2003, Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair., J Immunol, 171, 3655, 10.4049/jimmunol.171.7.3655

IN Holcomb, 2000, FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family., EMBO J, 19, 4046, 10.1093/emboj/19.15.4046

B Gerstmayer, 2003, Identification of RELMgamma, a novel resistin-like molecule with a distinct expression pattern., Genomics, 81, 588, 10.1016/S0888-7543(03)00070-3

J Bełtowski, 2003, Adiponectin and resistin–new hormones of white adipose tissue., Med Sci Monit, 9, RA55

T Liu, 2004, Regulation of found in inflammatory zone 1 expression in bleomycin-induced lung fibrosis: role of IL-4/IL-13 and mediation via STAT-6., J Immunol, 173, 3425, 10.4049/jimmunol.173.5.3425

AM Stütz, 2003, The Th2 cell cytokines IL-4 and IL-13 regulate found in inflammatory zone 1/resistin-like molecule alpha gene expression by a STAT6 and CCAAT/enhancer-binding protein-dependent mechanism., J Immunol, 170, 1789, 10.4049/jimmunol.170.4.1789

JP Edwards, 2006, Biochemical and functional characterization of three activated macrophage populations., J Leukoc Biol, 80, 1298, 10.1189/jlb.0406249

MG Nair, 2003, Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro., Immunol Lett, 85, 173, 10.1016/S0165-2478(02)00225-0

G Raes, 2002, FIZZ1 and Ym as tools to discriminate between differentially activated macrophages., Dev Immunol, 9, 151, 10.1080/1044667031000137629

MJ Chung, 2007, Antiapoptotic effect of found in inflammatory zone (FIZZ)1 on mouse lung fibroblasts., J Pathol, 212, 180, 10.1002/path.2161

T Liu, 2004, FIZZ1 stimulation of myofibroblast differentiation., Am J Pathol, 164, 1315, 10.1016/S0002-9440(10)63218-X

P Misson, 2004, Markers of macrophage differentiation in experimental silicosis., J Leukoc Biol, 76, 926, 10.1189/jlb.0104019

AL Mora, 2006, Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis., Am J Respir Cell Mol Biol, 35, 466, 10.1165/rcmb.2006-0121OC

MG Nair, 2005, Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells., Infect Immun, 73, 385, 10.1128/IAI.73.1.385-394.2005

Y Sun, 2008, Found in Inflammatory Zone 1 Induces Angiogenesis in Murine Models of Asthma., Lung

G Trujillo, 2008, A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis., Am J Pathol, 172, 1209, 10.2353/ajpath.2008.070832

TA Wynn, 2004, Fibrotic disease and the T(H)1/T(H)2 paradigm., Nat Rev Immunol, 4, 583, 10.1038/nri1412

RM Anthony, 2006, Memory T(H)2 cells induce alternatively activated macrophages to mediate protection against nematode parasites., Nat Med, 12, 955, 10.1038/nm1451

P Loke, 2007, Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection., J Immunol, 179, 3926, 10.4049/jimmunol.179.6.3926

JJ Reece, 2006, Innate immune responses to lung-stage helminth infection induce alternatively activated alveolar macrophages., Infect Immun, 74, 4970, 10.1128/IAI.00687-06

MG Chiaramonte, 2001, Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis., Hepatology, 34, 273, 10.1053/jhep.2001.26376

TR Ramalingam, 2008, Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain., Nat Immunol, 9, 25, 10.1038/ni1544

RM Reiman, 2006, Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity., Infect Immun, 74, 1471, 10.1128/IAI.74.3.1471-1479.2006

D Artis, 2004, RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract., Proc Natl Acad Sci U S A, 101, 13596, 10.1073/pnas.0404034101

MG Nair, 2008, Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation., J Immunol, 181, 4709, 10.4049/jimmunol.181.7.4709

A Munitz, 2008, Resistan-like molecule a promotes colitis., J Allergy Clin Immunol, 122, 1200, 10.1016/j.jaci.2008.10.017

DM Valenzuela, 2003, High-throughput engineering of the mouse genome coupled with high-resolution expression analysis., Nat Biotechnol, 21, 652, 10.1038/nbt822

M Hesse, 2001, Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism., J Immunol, 167, 6533, 10.4049/jimmunol.167.11.6533

D Voehringer, 2006, Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system., J Exp Med, 203, 1435, 10.1084/jem.20052448

B Blagoev, 2002, Inhibition of adipocyte differentiation by resistin-like molecule alpha. Biochemical characterization of its oligomeric nature., J Biol Chem, 277, 42011, 10.1074/jbc.M206975200

S Gordon, 2003, Alternative activation of macrophages., Nat Rev Immunol, 3, 23, 10.1038/nri978

G Raes, 2002, Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages., J Leukoc Biol, 71, 597, 10.1189/jlb.71.4.597

MG Chiaramonte, 1999, IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs., J Immunol, 162, 920, 10.4049/jimmunol.162.2.920

GJ McKenzie, 1999, Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses., J Exp Med, 189, 1565, 10.1084/jem.189.10.1565

MG Chiaramonte, 1999, An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response., J Clin Invest, 104, 777, 10.1172/JCI7325

PG Fallon, 2000, Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent., J Immunol, 164, 2585, 10.4049/jimmunol.164.5.2585

AL Mora, 2006, Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis., Am J Respir Cell Mol Biol, 35, 466, 10.1165/rcmb.2006-0121OC

Z Zhu, 1999, Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production., J Clin Invest, 103, 779, 10.1172/JCI5909

P Loke, 2005, Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection., Proc Natl Acad Sci U S A, 102, 9872, 10.1073/pnas.0503961102

R Persaud, 2007, Characterization of the immuno-regulatory response to the tapeworm Hymenolepis diminuta in the non-permissive mouse host., Int J Parasitol, 37, 393, 10.1016/j.ijpara.2006.09.012

RK Grencis, 2004, Interleukin-13: a key mediator in resistance to gastrointestinal-dwelling nematode parasites., Clin Rev Allergy Immunol, 26, 51, 10.1385/CRIAI:26:1:51

W Hans, 2000, Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice., Eur Cytokine Netw, 11, 67

M Wills-Karp, 1998, Interleukin-13: central mediator of allergic asthma., Science, 282, 2258, 10.1126/science.282.5397.2258