Retinoic Acid-Induced Protein 14 (RAI14) Promotes mTOR-Mediated Inflammation Under Inflammatory Stress and Chemical Hypoxia in a U87 Glioblastoma Cell Line

Xiaogang Shen1, JiaRui Zhang1, Xiaolong Zhang1, Yifan Wang1, Yunfeng Hu1, J. Guo2
1Key Laboratory of Drug Target and Drug for Degenerative Disease, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China
2State Key Laboratory Cultivation Base For TCM Quality and Efficacy, School of Medicine and Life Science, Nanjing University of Chinese Medicine, Nanjing, 210023, People’s Republic of China

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Caccamo A, Belfiore R, Oddo S (2018) Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer’s disease. Neurobiol Aging 68:59–67. https://doi.org/10.1016/j.neurobiolaging.2018.03.032

Chen T, Guo Y, Shan J, Zhang J, Shen X, Guo J, Liu XM (2018a) Vector analysis of cytoskeletal structural tension and the mechanisms that underpin spectrin-related forces in pyroptosis. Antioxid Redox Sign. https://doi.org/10.1089/ars.2017.7366

Chen WR, Liu HB, Chen YD, Sha Y, Ma Q, Zhu PJ, Mu Y (2018b) Melatonin attenuates myocardial ischemia/reperfusion injury by inhibiting autophagy via an AMPK/mTOR signaling pathway. Cell Physiol Biochem 47:2067–2076. https://doi.org/10.1159/000491474

Choi YJ et al (2012) Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion. PLoS ONE 7:e43418. https://doi.org/10.1371/journal.pone.0043418

Coffey RT, Shi Y, Long MJC, Marr MTN, Hedstrom L (2016) Ubiquilin-mediated small molecule inhibition of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem 291:5221–5233. https://doi.org/10.1074/jbc.M115.691584

Collignon E et al (2018) Immunity drives TET1 regulation in cancer through NF-kappaB. Sci Adv 4:7309. https://doi.org/10.1126/sciadv.aap7309

Cosin-Roger J et al (2017) Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation. Nat Commun 8:98. https://doi.org/10.1038/s41467-017-00213-3

Dan HC, Cooper MJ, Cogswell PC, Duncan JA, Ting JP, Baldwin AS (2008) Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Gene Dev 22:1490–1500. https://doi.org/10.1101/gad.1662308

Gu L, Huang B, Shen W, Gao L, Ding Z, Wu H, Guo J (2013) Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi. J Neuroinflamm 10:109. https://doi.org/10.1186/1742-2094-10-109

Guo F et al (2013) mTOR regulates DNA damage response through NF-kappaB-mediated FANCD2 pathway in hematopoietic cells. Leukemia 27:2040–2046. https://doi.org/10.1038/leu.2013.93

Guo YC, Wang YX, Ge YP, Yu LJ, Guo J (2018) Analysis of subcellular structural tension in axonal growth of neurons. Rev Neurosci 29:125–137. https://doi.org/10.1515/revneuro-2017-0047

Han R, Gao J, Zhai H, Xiao J, Ding Y, Hao J (2016) RAD001 (everolimus) attenuates experimental autoimmune neuritis by inhibiting the mTOR pathway, elevating Akt activity and polarizing M2 macrophages. Exp Neurol 280:106–114. https://doi.org/10.1016/j.expneurol.2016.04.005

Hara K et al (1997) Regulation of eIF-4E BP1 phosphorylation by mTOR. J Biol Chem 272:26457–26463

Hasson SA et al (2013) High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature 504:291–295. https://doi.org/10.1038/nature12748

Hay N, Sonenberg N (2004) Upstream and downstream of mTOR. Gene Dev 18:1926–1945

Hsu Y et al (2013) Genome-wide analysis of three-way interplay among gene expression, cancer cell invasion and anti-cancer compound sensitivity. BMC Med 11:106. https://doi.org/10.1186/1741-7015-11-106

Huttlin EL et al (2017) Architecture of the human interactome defines protein communities and disease networks. Nature 545:505–509. https://doi.org/10.1038/nature22366

Kielian T (2006) Toll-like receptors in central nervous system glial inflammation and homeostasis. J Neurosci Res 83:711–730

Kingwell K (2013) Neuro-oncology: everolimus for astrocytoma in tuberous sclerosis complex. Nat Rev Neurol 9:6. https://doi.org/10.1038/nrneurol.2012.257

Kutty RK et al (2001) Molecular characterization and developmental expression of NORPEG, a novel gene induced by retinoic acid. J Biol Chem 276:2831–2840

Kutty RK et al (2006) Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein. Biochem Bioph Res Co 345:1333–1341

Lee D et al (2007) IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 130:440–455

Li S et al (2008) Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism. Cell Metab 8:105–117. https://doi.org/10.1016/j.cmet.2008.06.013

Li J, Tang Y, Cai D (2012) IKKbeta/NF-kappaB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes. Nat Cell Biol 14:999–1012. https://doi.org/10.1038/ncb2562

Li J et al (2016) Nuclear PKC-theta facilitates rapid transcriptional responses in human memory CD4 + T cells through p65 and H2B phosphorylation. J Cell Sci 129:2448–2461. https://doi.org/10.1242/jcs.181248

Liu Y et al (2017) Peripheral immune tolerance alleviates the intracranial lipopolysaccharide injection-induced neuroinflammation and protects the dopaminergic neurons from neuroinflammation-related neurotoxicity. J Neuroinflamm 14:223. https://doi.org/10.1186/s12974-017-0994-3

Peng YF et al (2000) Ankycorbin: a novel actin cytoskeleton-associated protein. Genes Cells 5:1001–1008

Qian X, Mruk DD, Cheng CY (2013) Rai14 (retinoic acid induced protein 14) is involved in regulating f-actin dynamics at the ectoplasmic specialization in the rat testis*. PLoS ONE 8:e60656. https://doi.org/10.1371/journal.pone.0060656

Subhan F et al (2017) Fish scale collagen peptides protect against CoCl2/TNF-alpha-induced cytotoxicity and inflammation via inhibition of ROS, MAPK, and NF-kappaB pathways in HaCaT cells. Oxid Med Cell Longev 2017:9703609. https://doi.org/10.1155/2017/9703609

Temiz-Resitoglu M et al (2017) Activation of mTOR/IκB-α/NF-κB pathway contributes to LPS-induced hypotension and inflammation in rats. Eur J Pharmacol 802:7–19. https://doi.org/10.1016/j.ejphar.2017.02.034

Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM (2012) A unifying model for mTORC1-mediated regulation of mRNA translation. Nature 485:109–113. https://doi.org/10.1038/nature11083

Vitiello D, Neagoe P, Sirois MG, White M (2015) Effect of everolimus on the immunomodulation of the human neutrophil inflammatory response and activation. Cell Mol Immunol 12:40–52. https://doi.org/10.1038/cmi.2014.24

Wendel H et al (2004) Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428:332–337

Yang T, Li D, Liu F, Qi L, Yan G, Wang M (2015) Regulation on Beclin-1 expression by mTOR in CoCl2-induced HT22 cell ischemia-reperfusion injury. Brain Res 1614:60–66. https://doi.org/10.1016/j.brainres.2015.04.016

Yun S et al (2016) 4EBP1/c-MYC/PUMA and NF-kappaB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells. Blood 127:2711–2722. https://doi.org/10.1182/blood-2015-02-629485