Retard de croissance intra-utérin, petit poids de naissance et risque métabolique

Lavoisier - Tập 2 - Trang 166-172 - 2007
J. Beltrand1,2, C. Levy-Marchal1,2
1Inserm, U690, hôpital Robert-Debré, Paris, France
2Université Paris-VII, Paris, France

Tóm tắt

Depuis 15 ans, il est établi que la restriction de croissance fœtale aboutissant à un petit poids de naissance (PPN) module le risque de développer un diabète de type 2 ou des maladies cardiovasculaires. L’apparition précoce d’une insulino-résistance semble l’élément clé de ce phénomène. Son histoire naturelle reste cependant mal connue mais semble relier l’environnement nutritionnel intra-utérin, le rattrapage staturo-pondéral et les modifications métaboliques qui s’y associent et le tissu adipeux.

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