Resveratrol reverses the effect of TNF-α on inflammatory markers in a model of autoimmune uveitis

Brady, 2016, Corticosteroid implants for chronic non-infectious uveitis, Cochrane Database Syst. Rev., 2, CD010469 Crane, 2001, Expression of the chemokines MIP-1alpha, MCP-1, and RANTES in experimental autoimmune uveitis, Invest. Ophthalmol. Vis. Sci., 42, 1547 Park, 2014, Immunopathogenesis of ocular Behcet’s disease, J. Immunol. Res., 2014, 10.1155/2014/653539 Marques, 2009, Resveratrol: cellular actions of a potent natural chemical that confers a diversity of health benefits, Int. J. Biochem. Cell Biol., 41, 2125, 10.1016/j.biocel.2009.06.003 Rayalam, 2008, Phytochemicals and regulation of the adipocyte life cycle, J. Nutr. Biochem., 19, 717, 10.1016/j.jnutbio.2007.12.007 Gupta, 2014, Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols, Arch. Biochem. Biophys., 559, 91, 10.1016/j.abb.2014.06.006 Manna, 2000, Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation, J. Immunol., 164, 6509, 10.4049/jimmunol.164.12.6509 Liu, 2017, Resveratrol attenuates ICAM-1 expression and monocyte adhesiveness to TNF-alpha-treated endothelial cells: evidence for an anti-inflammatory cascade mediated by the miR-221/222/AMPK/p38/NF-kappaB pathway, Sci. Rep., 7, 44689, 10.1038/srep44689 Deng, 2011, Inhibition of TNF-alpha-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4’-trimethoxystilbene, Phytother. Res., 25, 451, 10.1002/ptr.3279 Wang, 2016, Resveratrol attenuated TNF-alpha-induced MMP-3 expression in human nucleus pulposus cells by activating autophagy via AMPK/SIRT1 signaling pathway, Exp. Biol. Med. (Maywood), 241, 848, 10.1177/1535370216637940 Tome-Carneiro, 2013, Resveratrol in primary and secondary prevention of cardiovascular disease: a dietary and clinical perspective, Ann. N. Y. Acad. Sci., 1290, 37, 10.1111/nyas.12150 Kubota, 2010, Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation, Am. J. Pathol., 177, 1725, 10.2353/ajpath.2010.100098 Kubota, 2009, Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation, Invest. Ophthalmol. Vis. Sci., 50, 3512, 10.1167/iovs.08-2666 Kutty, 2005, Multistate outbreak of toxic anterior segment syndrome, J. Cataract Refract. Surg., 2008, 585 Abu-Amero, 2016, Resveratrol and ophthalmic diseases, Nutrients, 8, 200, 10.3390/nu8040200 Bola, 2014, Resveratrol and the eye: activity and molecular mechanisms, Graefes Arch. Clin. Exp. Ophthalmol., 252, 699, 10.1007/s00417-014-2604-8 Lancon, 2016, Anti-oxidant, anti-inflammatory and anti-angiogenic properties of resveratrol in ocular diseases, Molecules, 21, 304, 10.3390/molecules21030304 Khan, 2010, Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway, Am. J. Pathol., 177, 481, 10.2353/ajpath.2010.090836 Pintea, 2011, Antioxidant effect of trans-resveratrol in cultured human retinal pigment epithelial cells, J. Ocul. Pharmacol. Ther., 27, 315, 10.1089/jop.2010.0144 Soufi, 2012, Chronic resveratrol administration has beneficial effects in experimental model of type 2 diabetic rats, Endocr. Regul., 46, 83, 10.4149/endo_2012_02_83 Rutar, 2016, Role of chemokines in shaping macrophage activity in AMD, Adv. Exp. Med. Biol., 854, 11, 10.1007/978-3-319-17121-0_2 Losso, 2010, Trans-resveratrol inhibits hyperglycemia-induced inflammation and connexin downregulation in retinal pigment epithelial cells, J. Agric. Food Chem., 58, 8246, 10.1021/jf1012067 Nagineni, 2014, Resveratrol suppresses expression of VEGF by human retinal pigment epithelial cells: potential nutraceutical for age-related macular degeneration, Aging Dis., 5, 88 Kurup, 2009, Therapeutic efficacy of intravitreal bevacizumab on posterior uveitis complicated by neovascularization, Acta Ophthalmol., 87, 349, 10.1111/j.1755-3768.2008.01208.x Moshfeghi, 2016, The role of Anti-VEGF therapy in the treatment of diabetic macular edema, Ophthalmic Surg. Lasers Imaging Retina, 47, S4, 10.3928/23258160-20160601-02 Richer, 2014, Resveratrol based oral nutritional supplement produces long-term beneficial effects on structure and visual function in human patients, Nutrients, 6, 4404, 10.3390/nu6104404 Richer, 2013, Observation of human retinal remodeling in octogenarians with a resveratrol based nutritional supplement, Nutrients, 5, 1989, 10.3390/nu5061989 Liew, 2016, Interleukin-33 in health and disease, Nature reviews, 16, 676 Barbour, 2014, IL-33 attenuates the development of experimental autoimmune uveitis, Eur. J. Immunol., 44, 3320, 10.1002/eji.201444671 Theodoropoulou, 2017, Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye, J. Pathol., 241, 45, 10.1002/path.4816 Hardman, 2016, Interleukin-33, friend and foe in type-2 immune responses, Curr. Opin. Immunol., 42, 16, 10.1016/j.coi.2016.05.004 Asadi-Samani, 2017, Inhibition of Th1 and Th17 cells by medicinal plants and their derivatives: a systematic review, Phytother. Res., 31, 1128, 10.1002/ptr.5837 Curnow, 2005, Multiplex bead immunoassay analysis of aqueous humor reveals distinct cytokine profiles in uveitis, Invest. Ophthalmol. Vis. Sci., 46, 4251, 10.1167/iovs.05-0444 Carreno, 2016, Cytokine and chemokine tear levels in patients with uveitis, Acta Ophthalmol., 95, e405, 10.1111/aos.13292 Tung, 2015, Anti-inflammatory effect of resveratrol in old mice liver, Exp. Gerontol., 64, 1, 10.1016/j.exger.2015.02.004 Kutty, 2015, Resveratrol attenuates CXCL11 expression induced by proinflammatory cytokines in retinal pigment epithelial cells, Cytokine, 74, 335, 10.1016/j.cyto.2015.03.016 Sugita, 2000, Soluble Fas ligand and soluble Fas in ocular fluid of patients with uveitis, Br. J. Ophthalmol., 84, 1130, 10.1136/bjo.84.10.1130 Li, 2009, Effect of resveratrol-induced FasL up-regulation on the apoptosis of pancreatic acinar cells in rats with severe acute pancreatitis, Nan fang yi ke da xue xue bao = J. Southern Medi. Uni., 29, 454 Mulakayala, 2013, Synthesis and evaluation of resveratrol derivatives as new chemical entities for cancer, J. Mol. Graph. Model., 41, 43, 10.1016/j.jmgm.2013.01.005 Su, 2005, Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells, Carcinogenesis, 26, 1, 10.1093/carcin/bgh220 Li, 2013, Resveratrol reduces acute lung injury in a LPS induced sepsis mouse model via activation of Sirt1, Mol. Med. Rep., 7, 1889, 10.3892/mmr.2013.1444 Petro, 2011, Regulatory role of resveratrol on Th17 in autoimmune disease, Int. Immunopharmacol., 11, 310, 10.1016/j.intimp.2010.07.011 Shindler, 2010, Oral resveratrol reduces neuronal damage in a model of multiple sclerosis, J. Neuroophthalmol., 30, 328, 10.1097/WNO.0b013e3181f7f833 Park, 2005, A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17, Nat. Immunol., 6, 1133, 10.1038/ni1261 Amadi-Obi, 2007, TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1, Nat. Med., 13, 711, 10.1038/nm1585 Wan, 2016, Cutting edge: IL-1 receptor signaling is critical for the development of autoimmune uveitis, J. Immunol., 196, 543, 10.4049/jimmunol.1502080 Zhang, 2015, Effects of curcumin on interleukin-23 and interleukin-17 expression in rat retina after retinal ischemia-reperfusion injury, Int. J. Clin. Exp. Pathol., 8, 9223 Bakheet, 2017, Resveratrol ameliorates dysregulation of Th1, Th2, Th17, and T regulatory cell-related transcription factor signaling in a BTBR T + tf/J mouse model of autism, Mol. Neurobiol., 54, 5201, 10.1007/s12035-016-0066-1 Lanzilli, 2012, Anti-inflammatory effect of resveratrol and polydatin by in vitro IL-17 modulation, Inflammation., 35, 240, 10.1007/s10753-011-9310-z Wang, 2015, Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit, Rheumatol. Int., 32, 1541, 10.1007/s00296-010-1720-y Yao, 2015, Effect of resveratrol on Treg/Th17 signaling and ulcerative colitis treatment in mice, World J. Gastroenterol., 21, 6572, 10.3748/wjg.v21.i21.6572 Iyer, 2012, Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease, Crit. Rev. Immunol., 32, 23, 10.1615/CritRevImmunol.v32.i1.30 Couper, 2008, IL-10: the master regulator of immunity to infection, J. Immunol., 180, 5771, 10.4049/jimmunol.180.9.5771 Jung, 2004, Expression profiling of IL-10-regulated genes in human monocytes and peripheral blood mononuclear cells from psoriatic patients during IL-10 therapy, Eur. J. Immunol., 34, 481, 10.1002/eji.200324323 Boocock, 2007, Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 848, 182, 10.1016/j.jchromb.2006.10.017 Meng, 2004, Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice, J. Agric. Food Chem., 52, 935, 10.1021/jf030582e Brown, 2010, Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis, Cancer Res., 70, 9003, 10.1158/0008-5472.CAN-10-2364 Chow, 2010, Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study, Cancer Prev. Res. Phila. (Phila), 3, 1168, 10.1158/1940-6207.CAPR-09-0155 Barry, 2014, Pharmacotherapy for uveitis: current management and emerging therapy, Clin. Ophthalmol., 8, 1891 Gilger, 2006, A novel bioerodible deep scleral lamellar cyclosporine implant for uveitis, Invest. Ophthalmol. Vis. Sci., 47, 2596, 10.1167/iovs.05-1540 FDA, 2017 Bansal, 2015, Experimental autoimmune uveitis and other animal models of uveitis: an update, Indian J. Ophthalmol., 63, 211, 10.4103/0301-4738.156914 Lee, 2014, Autoimmune and autoinflammatory mechanisms in uveitis, Semin. Immunopathol., 36, 581, 10.1007/s00281-014-0433-9 Juan, 2010, Multidrug resistance proteins restrain the intestinal absorption of trans-resveratrol in rats, J. Nutr., 140, 489, 10.3945/jn.109.114959