Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport in vivo

Fukao, 2004, Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice, Blood Coagul Fibrinolysis, 15, 441, 10.1097/00001721-200408000-00001 Do, 2008, Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice, Biochem Biophys Res Commun, 374, 55, 10.1016/j.bbrc.2008.06.113 Auger, 2005, Dietary wine phenolics catechin, quercetin, and resveratrol efficiently protect hypercholesterolemic hamsters against aortic fatty streak accumulation, J Agric Food Chem, 53, 2015, 10.1021/jf048177q Belguendouz, 1997, Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins, Biochem Pharmacol, 53, 1347, 10.1016/S0006-2952(96)00820-9 Zou, 1999, Resveratrol inhibits copper ion-induced and azo compound-initiated oxidative modification of human low density lipoprotein, Biochem Mol Biol Int, 47, 1089 Martin, 2006, The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model, Br J Pharmacol, 147, 873, 10.1038/sj.bjp.0706469 Berrougui, 2009, A new insight into resveratrol as an atheroprotective compound: inhibition of lipid peroxidation and enhancement of cholesterol efflux, Atherosclerosis, 207, 420, 10.1016/j.atherosclerosis.2009.05.017 Kaneko, 2011, Resveratrol prevents the development of abdominal aortic aneurysm through attenuation of inflammation, oxidative stress, and neovascularization, Atherosclerosis, 217, 350, 10.1016/j.atherosclerosis.2011.03.042 Ramprasath, 2010, Anti-atherogenic effects of resveratrol, Eur J Clin Nutr, 64, 660, 10.1038/ejcn.2010.77 Escola-Gil, 2009, In vivo macrophage-specific RCT and antioxidant and anti-inflammatory HDL activity measurements: new tools for predicting HDL atheroprotection, Atherosclerosis, 206, 321, 10.1016/j.atherosclerosis.2008.12.044 Rader, 2009, The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis, J Lipid Res, 50, S189, 10.1194/jlr.R800088-JLR200 Rosenson, 2012, Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport, Circulation, 125, 1905, 10.1161/CIRCULATIONAHA.111.066589 Howitz, 2003, Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan, Nature, 425, 191, 10.1038/nature01960 Baur, 2006, Resveratrol improves health and survival of mice on a high-calorie diet, Nature, 444, 337, 10.1038/nature05354 Lagouge, 2006, Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha, Cell, 127, 1109, 10.1016/j.cell.2006.11.013 Timmers, 2011, Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans, Cell Metab, 14, 612, 10.1016/j.cmet.2011.10.002 Pacholec, 2010, SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1, J Biol Chem, 285, 8340, 10.1074/jbc.M109.088682 Sevov, 2006, Resveratrol regulates the expression of LXR-alpha in human macrophages, Biochem Biophys Res Commun, 348, 1047, 10.1016/j.bbrc.2006.07.155 Li, 2007, SIRT1 deacetylates and positively regulates the nuclear receptor LXR, Mol Cell, 28, 91, 10.1016/j.molcel.2007.07.032 Qiang, 2011, Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation, Cell Metab, 14, 758, 10.1016/j.cmet.2011.10.007 Stein, 2010, SIRT1 decreases Lox-1-mediated foam cell formation in atherogenesis, Eur Heart J, 31, 2301, 10.1093/eurheartj/ehq107 Zhang, 2003, Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo, Circulation, 108, 661, 10.1161/01.CIR.0000086981.09834.E0 Banks, 2008, SirT1 gain of function increases energy efficiency and prevents diabetes in mice, Cell Metab, 8, 333, 10.1016/j.cmet.2008.08.014 Julve, 2010, Human apolipoprotein A-II determines plasma triglycerides by regulating lipoprotein lipase activity and high-density lipoprotein proteome, Arterioscler Thromb Vasc Biol, 30, 232, 10.1161/ATVBAHA.109.198226 Escola-Gil, 2011, The cholesterol content of Western diets plays a major role in the paradoxical increase in high-density lipoprotein cholesterol and upregulates the macrophage reverse cholesterol transport pathway, Arterioscler Thromb Vasc Biol, 31, 2493, 10.1161/ATVBAHA.111.236075 Andres-Lacueva, 2012, Distribution of resveratrol metabolites in liver, adipose tissue, and skeletal muscle in rats fed different doses of this polyphenol, J Agric Food Chem, 60, 4833, 10.1021/jf3001108 Rotches-Ribalta, 2012, Gut and microbial resveratrol metabolite profiling after moderate long-term consumption of red wine versus dealcoholized red wine in humans by an optimized ultra-high-pressure liquid chromatography tandem mass spectrometry method, J Chromatogr A, 10.1016/j.chroma.2012.09.093 Calpe-Berdiel, 2008, Liver X receptor-mediated activation of reverse cholesterol transport from macrophages-to-feces in vivo requires ABCG5/G8, J Lipid Res, 49, 1904, 10.1194/jlr.M700470-JLR200 Silvennoinen, 2012, Acute psychological stress accelerates reverse cholesterol transport via corticosterone-dependent inhibition of intestinal cholesterol absorption, Circ Res, 111, 1459 Zanotti, 2008, The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential, J Lipid Res, 49, 954, 10.1194/jlr.M700254-JLR200 Naik, 2006, Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo, Circulation, 113, 90, 10.1161/CIRCULATIONAHA.105.560177 Yu, 2003, Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8, J Biol Chem, 278, 15565, 10.1074/jbc.M301311200 Grefhorst, 2012, Pharmacological LXR activation reduces presence of SR-B1 in liver membranes contributing to LXR-mediated induction of HDL-cholesterol, Atherosclerosis, 222, 382, 10.1016/j.atherosclerosis.2012.02.014 Chen, 2012, Dietary resveratrol increases the expression of hepatic 7alpha-hydroxylase and ameliorates hypercholesterolemia in high fat-fed C57BL/6J mice, Lipids Health Dis, 11, 56, 10.1186/1476-511X-11-56 Li, 2010, Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice, Hepatology, 52, 678, 10.1002/hep.23721 Mendez-Gonzalez, 2010, Disodium ascorbyl phytostanol phosphate (FM-VP4), a modified phytostanol, is a highly active hypocholesterolaemic agent that affects the enterohepatic circulation of both cholesterol and bile acids in mice, Br J Nutr, 103, 153, 10.1017/S0007114509991656 Rocha, 2009, Resveratrol toxicity: effects on risk factors for atherosclerosis and hepatic oxidative stress in standard and high-fat diets, Food Chem Toxicol, 47, 1362, 10.1016/j.fct.2009.03.010 Lehmann, 1997, Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway, J Biol Chem, 272, 3137, 10.1074/jbc.272.6.3137