Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

Cell Metabolism - Tập 8 Số 2 - Trang 157-168 - 2008
Kevin J. Pearson1, Joseph A. Baur2, Kaitlyn N. Lewis3, Leonid Peshkin2, Nathan L. Price4,1, Nazar Labinskyy5, William R. Swindell6, Davida Kamara3, Robin K. Minor3, Evelyn Perez3, Hamish A. Jamieson7, Yongqing Zhang3, Stephen Dunn8, Kumar Sharma9, Nancy Pleshko10, Laura A. Woollett11, Anna Csiszár5, Yuji Ikeno12, David G. Le Couteur7, Peter J. Elliott13, Kevin G. Becker3, Plácido Navas14, Donald K. Ingram15, Norman S. Wolf16, Zoltán Ungvári5, David Sinclair2, Rafael de Cabo3
1Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.
2Harvard University
3NATIONAL INSTITUTES OF HEALTH
4Department of Pathology and Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston MA 02115, USA
5New York Medical College
6Department of Pathology, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48103, USA
7University of Sydney
8Johns Hopkins University
9University of california at San Diego
10Hospital for Special Surgery - New York
11Genome Research Institute
12Barshop Institute for Longevity and Aging Studies and Department of Pathology, University of Texas Health Science Center at San Antonio, and Research Service, Audie Murphy VA Hospital (STVHCS),15355 Lambda Drive, San Antonio, TX 78245-3207, USA
13(GlaxoSmithKline)
14Instituto de Salud Carlos III
15LSU Pennington Biomedical Research Center
16University of Washington

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Anderson, 2003, Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae, Nature, 423, 181, 10.1038/nature01578

Barger, 2003, The retardation of aging by caloric restriction: its significance in the transgenic era, Exp. Gerontol., 38, 1343, 10.1016/j.exger.2003.10.017

Barger, 2008, A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice, PLoS ONE, 3, e2264, 10.1371/journal.pone.0002264

Bass, 2007, Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans, Mech. Ageing Dev., 128, 546, 10.1016/j.mad.2007.07.007

Bauer, 2004, An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster, Proc. Natl. Acad. Sci. USA, 101, 12980, 10.1073/pnas.0403493101

Baur, 2006, Therapeutic potential of resveratrol: the in vivo evidence, Nat. Rev. Drug Discov., 5, 493, 10.1038/nrd2060

Baur, 2006, Resveratrol improves health and survival of mice on a high-calorie diet, Nature, 444, 337, 10.1038/nature05354

Benjamini, 1995, Controlling the false discovery rate: a powerful and practical approach to multiple testing, J. Roy. Statist. Soc. Ser. B, 57, 289

Boily, 2008, SirT1 regulates energy metabolism and response to caloric restriction in mice, PLoS ONE, 3, e1759, 10.1371/journal.pone.0001759

Bordone, 2007, SIRT1 transgenic mice show phenotypes resembling calorie restriction, Aging Cell, 6, 759, 10.1111/j.1474-9726.2007.00335.x

Bowdish, 2006, Immunomodulatory properties of defensins and cathelicidins, Curr. Top. Microbiol. Immunol., 306, 27

Cao, 2001, Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice, Proc. Natl. Acad. Sci. USA, 98, 10630, 10.1073/pnas.191313598

Cheadle, 2003, Analysis of microarray data using Z score transformation, J. Mol. Diagn., 5, 73, 10.1016/S1525-1578(10)60455-2

Chen, 2005, Increase in activity during calorie restriction requires Sirt1, Science, 310, 1641, 10.1126/science.1118357

Corton, 2004, Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors, J. Biol. Chem., 279, 46204, 10.1074/jbc.M406739200

Crews, 2005, Artificial environments and an aging population: designing for age-related functional losses, J. Physiol. Anthropol. Appl. Human Sci., 24, 103, 10.2114/jpa.24.103

Crowell, 2004, Resveratrol-associated renal toxicity, Toxicol. Sci., 82, 614, 10.1093/toxsci/kfh263

Csiszar, 2004, Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging, Physiol. Genomics, 17, 21, 10.1152/physiolgenomics.00136.2003

Csiszar, 2007, Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging, Am. J. Pathol., 170, 388, 10.2353/ajpath.2007.060708

Csiszar, 2007, Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity, Aging Cell, 6, 783, 10.1111/j.1474-9726.2007.00339.x

Dhahbi, 2005, Identification of potential caloric restriction mimetics by microarray profiling, Physiol. Genomics, 23, 343, 10.1152/physiolgenomics.00069.2005

Dhahbi, 2006, Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction, J. Gerontol A Biol. Sci. Med. Sci., 61, 218, 10.1093/gerona/61.3.218

Edwards, 2007, Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program, BMC Genomics, 8, 80, 10.1186/1471-2164-8-80

Fu, 2006, Tissue specific and non-specific changes in gene expression by aging and by early stage CR, Mech. Ageing Dev., 127, 905, 10.1016/j.mad.2006.09.006

Gass, 2006, Preventing osteoporosis-related fractures: an overview, Am. J. Med., 119, S3, 10.1016/j.amjmed.2005.12.017

Goodrick, 1990, Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age, Mech. Ageing Dev., 55, 69, 10.1016/0047-6374(90)90107-Q

Goodrick, 1982, Effects of intermittent feeding upon growth and life span in rats, Gerontology, 28, 233, 10.1159/000212538

Guo, 2002, Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice, Mech. Ageing Dev., 123, 1121, 10.1016/S0047-6374(02)00008-8

Guzik, 2007, Endothelial NF-kappaB as a mediator of kidney damage: the missing link between systemic vascular and renal disease?, Circ. Res., 101, 227, 10.1161/CIRCRESAHA.107.158295

Heilbronn, 2006, Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial, JAMA, 295, 1539, 10.1001/jama.295.13.1539

Higami, 2004, Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction, FASEB J., 18, 415, 10.1096/fj.03-0678fje

Hong, 2006, RankProd: a bioconductor package for detecting differentially expressed genes in meta-analysis, Bioinformatics, 22, 2825, 10.1093/bioinformatics/btl476

Howitz, 2003, Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan, Nature, 425, 191, 10.1038/nature01960

Ingram, 2004, Development of calorie restriction mimetics as a prolongevity strategy, Ann. N Y Acad. Sci., 1019, 412, 10.1196/annals.1297.074

Jarolim, 2004, A novel assay for replicative lifespan in Saccharomyces cerevisiae, FEM. Yeast Res., 5, 169, 10.1016/j.femsyr.2004.06.015

Kaeberlein, 1999, The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms, Genes Dev., 13, 2570, 10.1101/gad.13.19.2570

Kaplan, 1967, On the natural history of the murine leukemias: presidential address, Cancer Res., 27, 1325

Kim, 2005, PAGE: parametric analysis of gene set enrichment, BMC Bioinformatics, 6, 144, 10.1186/1471-2105-6-144

Labinskyy, 2006, Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen, Curr. Med. Chem., 13, 989, 10.2174/092986706776360987

Lagouge, 2006, Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha, Cell, 127, 1109, 10.1016/j.cell.2006.11.013

Lakatta, 2003, Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a “set up” for vascular disease, Circulation, 107, 139, 10.1161/01.CIR.0000048892.83521.58

Lane, 1998, 2-Deoxy-D-glucose feeding in rats mimics physiological effects of calorie restriction, J. Anti Aging Med., 1, 327, 10.1089/rej.1.1998.1.327

Lee, 1999, Gene expression profile of aging and its retardation by caloric restriction, Science, 285, 1390, 10.1126/science.285.5432.1390

Lee, 2002, Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts, Proc. Natl. Acad. Sci. USA, 99, 14988, 10.1073/pnas.232308999

Lin, 2000, Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae, Science, 289, 2126, 10.1126/science.289.5487.2126

Liu, 2005, Effects of trans-resveratrol from Polygonum cuspidatum on bone loss using the ovariectomized rat model, J. Med. Food, 8, 14, 10.1089/jmf.2005.8.14

Mayo, 2003, Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway, J. Biol. Chem., 278, 18980, 10.1074/jbc.M211695200

McCay, 1935, The effect of retarded growth upon the length of life span and upon the ultimate body size, J. Nutr., 10, 63, 10.1093/jn/10.1.63

Moynihan, 2005, Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice, Cell Metab., 2, 105, 10.1016/j.cmet.2005.07.001

Revollo, 2004, The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells, J. Biol. Chem., 279, 50754, 10.1074/jbc.M408388200

Risser, 1983, Endogenous mouse leukemia viruses, Annu. Rev. Genet., 17, 85, 10.1146/annurev.ge.17.120183.000505

Roberts, 2006, Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome, Metabolism, 55, 928, 10.1016/j.metabol.2006.02.022

Rogina, 2004, Sir2 mediates longevity in the fly through a pathway related to calorie restriction, Proc. Natl. Acad. Sci. USA, 101, 15998, 10.1073/pnas.0404184101

Russell, 1992, Bile acid biosynthesis, Biochemistry, 31, 4737, 10.1021/bi00135a001

Scalia, 2007, Hyperglycemia is a major determinant of albumin permeability in diabetic microcirculation: the role of mu-calpain, Diabetes, 56, 1842, 10.2337/db06-1198

Selman, 2006, Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice, Physiol. Genomics, 27, 187, 10.1152/physiolgenomics.00084.2006

Sohal, 1996, Oxidative stress, caloric restriction, and aging, Science, 273, 59, 10.1126/science.273.5271.59

Spindler, 2006, Use of microarray biomarkers to identify longevity therapeutics, Aging Cell, 5, 39, 10.1111/j.1474-9726.2006.00194.x

Su, 2007, Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol, J. Biol. Chem., 282, 19385, 10.1074/jbc.M702452200

Subramanian, 2005, Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, Proc. Natl. Acad. Sci. USA, 102, 15545, 10.1073/pnas.0506580102

Sun, 2007, SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B, Cell Metab., 6, 307, 10.1016/j.cmet.2007.08.014

Swindell, 2008, Comparative analysis of microarray data identifies common responses to caloric restriction among mouse tissues, Mech. Ageing Dev., 129, 138, 10.1016/j.mad.2007.11.003

Tissenbaum, 2001, Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans, Nature, 410, 227, 10.1038/35065638

Trinh, 1998, Perturbation of fuel homeostasis caused by overexpression of the glucose-6-phosphatase catalytic subunit in liver of normal rats, J. Biol. Chem., 273, 31615, 10.1074/jbc.273.47.31615

Tsuchiya, 2004, Additive regulation of hepatic gene expression by dwarfism and caloric restriction, Physiol. Genomics, 17, 307, 10.1152/physiolgenomics.00039.2004

Turturro, 1999, Growth curves and survival characteristics of the animals used in the Biomarkers of Aging Program, J. Gerontol. A. Biol. Sci. Med. Sci., 54, B492, 10.1093/gerona/54.11.B492

Ungvari, 2007, Resveratrol increases vascular oxidative stress resistance, Am. J. Physiol., 292, H2417

Vaitkevicius, 1993, Effects of age and aerobic capacity on arterial stiffness in healthy adults, Circulation, 88, 1456, 10.1161/01.CIR.88.4.1456

Valenzano, 2006, Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate, Curr. Biol., 16, 296, 10.1016/j.cub.2005.12.038

Viswanathan, 2005, A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span, Dev. Cell, 9, 605, 10.1016/j.devcel.2005.09.017

Weindruch, 1982, Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence, Science, 215, 1415, 10.1126/science.7063854

Welsh, 2005, Normal motor learning during pharmacological prevention of Purkinje cell long-term depression, Proc. Natl. Acad. Sci. USA, 102, 17166, 10.1073/pnas.0508191102

Wolf, 2000, Normal mouse and rat strains as models for age-related cataract and the effect of caloric restriction on its development, Exp. Eye Res., 70, 683, 10.1006/exer.2000.0835

Wolf, 2005, Age-related cataract progression in five mouse models for anti-oxidant protection or hormonal influence, Exp. Eye Res., 81, 276, 10.1016/j.exer.2005.01.024

Wood, 2004, Sirtuin activators mimic caloric restriction and delay ageing in metazoans, Nature, 430, 686, 10.1038/nature02789