Resting EEG and ERPs findings in methadone-substituted opiate users: a review
Tóm tắt
Methadone has been used to treat opiate dependence since the mid-1960s. Despite its clinical effectiveness there is evidence from neuropsychological studies demonstrating that its long-term use might have negative effects on cognition. Nevertheless, it remains uncertain whether the observed cognitive impairments in patients undertaking methadone maintenance treatment (MMT) are solely attributable to the pharmacological effects of methadone, as suggested by some researchers. Determining the effects of MMT on neuropsychological function using electroencephalography (EEG) combined with event-related potentials (ERP) has been used infrequently. However EEG and ERP provide a means of closely examining information processing to determine whether MMT induces any deficits. The purpose of this review was to investigate whether psychophysiological evidence supports cognitive impairment in association with MMT by focusing on research using EEG and ERPs. The findings of EEG studies to date appear not support the notion that cognitive impairments are attributable to the specific pharmacological effects of methadone suggested by some neuropsychological studies. However, due to the methodological deficits and limited number of the studies, any conclusion based on the findings of the existing EEG studies should be avoided.
Tài liệu tham khảo
Garrido MJ, Trocóniz IF (1999) Methadone: a review of its pharmacokinetic/pharmacodynamic properties. J Pharmacol Toxicol Methods 42(2):61–66
Marsch LA (1998) The efficacy of methadone maintenance interventions in reducing illicit opiate use, HIV risk behavior and criminality: a meta-analysis. Addiction 93(4):515–532
Gibson DR, Flynn NM, McCarthy JJ (1999) Effectiveness of methadone treatment in reducing HIV risk behavior and HIV seroconversion among injecting drug users. Aids 13(14):1807–1818
Wang GY, Wouldes TA, Russell BB (2013) Methadone maintenance treatment and cognitive function: a systematic review. Curr Drug Abuse Rev 6(3):220–230
Prosser J, Cohen LJ, Steinfeld M, Eisenberg D, London ED, Galynker II (2006) Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment. Drug Alcohol Depen 84(3):240–247 PubMed PMID: 2006420273
Verdejo A, Toribio I, Orozco C, Puente KL, Perez-Garcia M (2005) Neuropsychological functioning in methadone maintenance patients versus abstinent heroin abusers. Drug Alcohol Depen 78(3):283–288 PubMed PMID: 2005225732
Darke S, Sims J, McDonald S, Wickes W (2000) Cognitive impairment among methadone maintenance patients. Addiction 95(5):687–695
Mintzer MZ, Stitzer ML (2002) Cognitive impairment in methadone maintenance patients. Drug Alcohol Depen 67(1):41–51
Rapeli P, Fabritius C, Kalska H, Alho H (2009) Memory function in opioid-dependent patients treated with methadone or buprenorphine along with benzodiazepine: longitudinal change in comparison to healthy individuals. Subst Abuse Treat Pr 4(6):1–15
Pirastu R, Fais R, Messina M, Bini V, Spiga S, Falconieri D et al (2006) Impaired decision-making in opiate-dependent subjects: effect of pharmacological therapies. Drug Alcohol Depen 83(2):163–168 (PubMed PMID: Peer Reviewed Journal: 2006-07783-009)
Rapeli P, Fabritius C, Alho H, Salaspuro M, Wahlbeck K, Kalska H (2007) Methadone vs. buprenorphine/naloxone during early opioid substitution treatment: a naturalistic comparison of cognitive performance relative to healthy controls. BMC Clin Pharmacol 7(1):5
Davis PE, Liddiard H, McMillan TM (2002) Neuropsychological deficits and opiate abuse. Drug Alcohol Depen 67(1):105–108 (PubMed PMID: Peer Reviewed Journal: 2002-17450-011)
Soyka M, Lieb M, Kagerer S, Zingg C, Koller G, Lehnert P et al (2008) Cognitive functioning during methadone and buprenorphine treatment: results of a randomized clinical trial. J Clin Psychopharmacol 28(6):699–703
Appel PW (1982) Sustained attention in methadone patients. Subst Use Misuse 17:1313–1327
Appel P, Gordon N (1976) Digit-symbol performance in methadone-treated ex-heroin addicts. Am J Psychiatry 133:1337–1340
Specka M, Finkbeiner T, Lodemann E, Leifert K, Kluwig J, Gastpar M (2000) Cognitive-motor performance of methadone-maintained patients. Eur Addict Res 6:8–19
Grevert P, Masover B, Goldstein A (1977) Failure of methadone and levomethadyl acetate (levo-alpha-acetylmethadol, LAAM) maintenance to affect memory. Arch Gen Psychiatry 34(7):849–853 (PubMed PMID: Peer Reviewed Journal: 1978-12936-001)
Ersche KD, Roiser JP, Clark L, London M, Robbins TW, Sahakian BJ (2005) Punishment induces risky decision-making in methadone-maintained opiate users but not in heroin users or healthy volunteers. Neuropsychopharmacology 30(11):2115–2124
Gordon NB (1970) Reaction-times of methadone treated ex heroin addicts. Psychopharmacology. 16:337–344
Rothenberg S, Meyer RE, Rauss B, Gross K (1977) Performance differences between addicts and non-addicts. Psychopharmacology 52(3):299–306
Corradini PL, Persinger MA (2014) Spectral power, source localization and microstates to quantify chronic deficits from ‘mild’ closed head injury: correlation with classic neuropsychological tests. Brain Inj 2014(28):1317–1327
Klimesch W, Vogt F, Doppelmayr M (1999) Interindividual differences in alpha and theta power reflect memory performance. Intelligence 27(4):347–362
Ray W, Cole H (1985) EEG alpha activity reflects attentional demands, and beta activity reflects emotional and cognitive processes. Science 228(4700):750–752
Barry RJ, Clarke AR, Johnstone SJ, Magee CA, Rushby JA (2007) EEG differences between eyes-closed and eyes-open resting conditions. Clin Neurophysiol 118(12):2765–2773
Alexander DM, Trengove C, Wright JJ, Boord PR, Gordon E (2006) Measurement of phase gradients in the EEG. J Neurosci Methods 156(1–2):111–128
Klimesch W, Sauseng P, Hanslmayr S (2007) EEG alpha oscillations: the inhibition–timing hypothesis. Brain Res Rev 53:63–88
Gritz ER, Shiffman SM, Jarvik ME, Haber J, Dymond AM, Coger R et al (1975) Physiological and psychological effects of methadone in man. Arch Gen Psychiatry 32(2):237–242
Feinstein B, Hanley J (1975) EEG findings in heroin addicts during induction and maintenance on methadone. Electroencephalogr Clin Neurophysiol 39(1):96–99
Fingelkurts AA, Fingelkurts AA, Kivisaari R, Autti T, Borisov S, Puuskari V et al (2007) Composition of EEG oscillations and their temporal characteristics. Int J Psychophysiol 64:130–140
Fingelkurts AA, Fingelkurts AA, Kivisaari R, Autti T, Borisov S, Puuskari V et al (2009) Methadone restores local and remote EEG functional connectivity in opioid. Int J Neurosci 119(9):1469–1493
Gorricho D, Valdizanuson JR (2008) QEEG mapping and methadone. Eur J Psychiat Online 22(1):29–37
Kay DC (1975) Human sleep and EEG through a cycle of methadone dependence. Electroencephalogr Clin Neurophysiol 38(1):35–43
Lenn NJ, Senay EC, Renault PF, Deuel RK (1976) Neurological assessment of patients on prolonged methadone maintenance. Drug Alcohol Depen 1(4):305–311
Martin WR, Jasinski DR, Haertzen CA, Kay DC, Jones BE, Mansky PA et al (1973) Methadone–a reevaluation. Arch Clin Neuropsychol 28(2):286–295
Wang GY, Kydd R, Wouldes TA, Jensen M, Russell BR (2015) Changes in resting EEG following methadone treatment in opiate addicts. Clin Neurophysiol 126:943–950
Danion JM, Weingartner H, File SE, Jaffard R, Sunderland T, Tulving E et al (1993) Pharmacology of human memory and cognition: illustrations from the effects of benzodiazepines and cholinergic drugs. J Psychopharmacol 7(4):371–377
Oades R, Dittmann-Balcar A, Schepker R, Eggers C, Zerbin D (1996) Auditory event-related potentials (ERPs) and mismatch negativity (MMN) in healthy children and those with attentiondeficitor Tourettic symptoms. Biol Psychol 43:163–185
Laurent A, Garcia-Larréa L, d’Amato T, Bosson J, Saoud M, Marie-Cardine M (1999) Auditory event-related potentials and clinical scores in unmedicated schizophrenic patients. Psychiatry Res 86:229–238
Llinás R, Ribary U (1993) Coherent 40-Hz oscillation characterizes dream state in humans. Proceed Natl Acad Sci 90(5):2078–2081
Boutros NN, Torello M, McGlashan TH (2003) Electrophysiological Aberrations in Borderline Personality Disorder: State of the Evidence The Journal of Neuropsychiatry and Clinical Neurosciences. 15:145–154
Markand ON (2003) Pearls, perils, and pitfalls in the use of the electroencephalogram. Semin Neurol 23(1):7–46
Wolff K, Rostami-Hodjegan A, Hay AWM, Raistrick D, Tucker G (2000) Population-based pharmacokinetic approach for methadone monitoring of opiate addicts: potential clinical utility. Addiction 95(12):1771–1783
Ceballos NA, Bauer L, Houston R (2009) Recent EEG and ERP findings in substance abusers. Clin EEG Neurosci 40(2):122–128
Halgren E, Marinkovic K, Chauvel P (1998) Generators of the late cognitive potentials in auditory and visual oddball tasks. Electroencephalogr Clin Neurophysiol 106(2):156–164
Mulert C, Pogarell O, Hegerl U (2010) Event-related potentials in psychiatry and clinical pharmacology:Basics, applicationa and relationship to fMRI. In: Drinkenburg WHIM, Ruigt GSF, Jobert M (eds) Essentials and applications of EEG research in preclinical and clinical pharmacology. IPEG, Belgium, pp 165–172
Tecce JJ, Cole JO, Mayer J, Lewis DC (1979) Methadone effects on brain functioning and Type A and B CNV shapes. Psychopharmacology 65(1):21–25
Nagai Y, Critchley HD, Featherstone E, Fenwick PBC, Trimble MR, Dolan RJ (2004) Brain activity relating to the contingent negative variation: an fMRI investigation. NeuroImage 21(4):1232–1241
Pritchard W, Sokhadze E, Houlihan M (2004) Effects if nicotine and smoking on event-related potentials: a reivew. Nicotine Tob Res. 6(6):961–984
Di Russo F, Pitzalis S, Spitoni G, Aprile T, Patria F, Spinelli D et al (2005) Identification of the neural sources of the pattern-reversal VEP. NeuroImage 24(3):874–886
Bauer L (1998) Effects of chronic opioid dependence and HIV-1 infection on pattern shift visual evoked potentials. Drug Alcohol Depen 50(2):147–155
Patel S, Azzam P (2005) Characterization of N200 and P300: selected studies of the event-related potential. Int J Med Sci 2(4):147–154
Wickens C, Karmer A, Vanasse L, Donchin E (1983) The performance of concurrent tasks:a psychophysiological analysis of the reciprocity of inofrmation processsing resources. Science 221:1080–1082
Polich J (1986) Attention, probability, and task demands as determinants of P300 latency from auditory stimuli. Electroencephalogr Clin Neurophysiol 63(3):251–259
Alexander JE, Bauer LO, Kuperman S, Morzorati S, O’Connor SJ, Rohrbaugh J et al (1996) Hemispheric differences for P300 amplitude from an auditory oddball task. Int J Psychophysiol 21(2–3):189–196
Attou A, Figiel C, Timsit-Berthier M (2001) Opioid addiction: P300 assessment in treatment by methadone substitution. Neurophysiol Clin 31(3):171–180
Kouri E, Lukas S, Mendelson J (1996) P300 assessment of opiate and cocaine users: effects of detoxification and buprenorphine treatment. Biol Psychoiatry 40:617–628
Muller BW, Specka M, Steinchen N, Zerbin D, Lodemann E, Finkbeiner T et al (2007) Auditory target processing in methadone substituted opiate addicts: The effect of nicotine in controls. BMC Psychiatry 7:1–9 (PubMed PMID: Peer Reviewed Journal: 2008-10167-001)
Yang L, Xu Q, Li S, Zhao X, Ma L, Zheng Y, et al. (2015) The effects of methadone maintenance treatment on heroin addicts with response inhibition function impairments: evidence from event-related potentials. J Food Drug Anal (in Press)
Hart CL, Marvin CB, Silver R, Smith EE (2012) Is cognitive functioning impaired in methamphetamine users [quest] a critical review. Neuropsychopharmacology 37(3):586–608
Hart CL, Ilan AB, Gevins A, Gunderson EW, Role K, Colley J et al (2010) Neurophysiological and cognitive effects of smoked marijuana in frequent users. Pharmacol Biochem Behav 96(3):333–341
Gevins A, Ilan AB, Jiang A, Sam-Vargas L, Baum C, Chan CS (2011) Combined neuropsychological and neurophysiological assessment of drug effects on groups and individuals. J Psychopharmcol 25:1062–1075
Kenemans JL, Kahkonen S (2011) How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control. Neuropsychopharmacology 36(1):26–51