Sử dụng dịch vụ chăm sóc sức khỏe liên quan đến nhiễm trùng đường hô hấp ở trẻ em mắc hội chứng Down

Springer Science and Business Media LLC - Tập 48 Số 3 - Trang 403-410 - 2020
Logan Manikam1, Anne G. M. Schilder2, Monica Lakhanpaul3,4, Peter Littlejohns5, Emma Alexander6, Andrew Hayward1
1UCL Institute of Epidemiology and Healthcare, University College London, London, UK
2National Institute of Health Research, University College London Hospitals Biomedical Research Centre, London, UK
3Population, Policy & Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, UK
4Whittington Health NHS Trust, London, UK
5Centre for Implementation Science, Institute of Psychiatry, Psychology and Neurosciences, King’s College London, Camberwell, London, UK
6Paediatric Liver, GI and Nutrition Centre and Mowatlabs, King’s College Hospital, London, UK

Tóm tắt

Tóm tắt Mục đích Trẻ em mắc hội chứng Down (DS) có xu hướng dễ mắc các bệnh nhiễm trùng đường hô hấp (RTIs) do sự biến đổi về mặt giải phẫu, sự chưa trưởng thành của hệ miễn dịch và các tình trạng bệnh kèm theo. Tuy nhiên, bằng chứng về việc sử dụng dịch vụ chăm sóc sức khỏe liên quan đến RTI, đặc biệt trong chăm sóc ban đầu, vẫn chưa đầy đủ. Trong nghiên cứu hồi cứu này, chúng tôi sử dụng dữ liệu chăm sóc ban đầu và thứ cấp được thu thập thường xuyên để định lượng việc sử dụng dịch vụ chăm sóc sức khỏe liên quan đến RTI ở trẻ em mắc DS và các đối chứng không mắc DS tương ứng.

Từ khóa

#hội chứng Down #nhiễm trùng đường hô hấp #sử dụng dịch vụ chăm sóc sức khỏe #trẻ em #nghiên cứu hồi cứu

Tài liệu tham khảo

Wu J, Morris JK. Trends in maternal age distribution and the live birth prevalence of Down's syndrome in England and Wales: 1938–2010. Eur J Hum Genet. 2013;21:943–7.

Watts R, Vyas H. An overview of respiratory problems in children with Down's syndrome. Arch Dis Childh. 2013;812–817.

Korppi M, Heiskanen-Kosma T, Jalonen E, Saikku P, Leinonen M, Halonen P, Makela PH. Aetiology of community-acquired pneumonia in children treated in hospital. Eur J Pediatr. 1993;152:24–30.

Petersen I, Johnson A, Islam A, Duckworth G, Livermore D, Hayward A. Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database. BMJ. 2007;335:982.

Fitzgerald P, Leonard H, Pikora T, Bourke J, Hammond G. Hospital admissions in children with down syndrome: experience of a population-based cohort followed from birth. PLoS ONE. 2013;8:e70401.

So SA, Urbano RC, Hodapp RM. Hospitalizations of infants and young children with Down syndrome: evidence from inpatient person-records from a statewide administrative database. J Intellect Disabil Res. 2007;51:1030–8.

Herrett E, Gallagher AM, Bhaskaran K, Forbes H, Mathur R, van Staa T, Smeeth L. Data resource profile: clinical practice research datalink (CPRD). Int J Epidemiol. 2015;44:827–36.

Hospital Episode Statistics [https://content.digital.nhs.uk/hes]

Herrett E, Smeeth L, Walker L, Weston C, Group MA. The myocardial ischaemia national audit project (MINAP). Heart. 2010;96:1264–7.

CALIBERcodelist [https://caliberanalysis.r-forge.r-project.org/]

Hay AD, Redmond NM, Turnbull S, Christensen H, Thornton H, Little P, Thompson M, Delaney B, Lovering AM, Muir P et al: Development and internal validation of a clinical rule to improve antibiotic use in children presenting to primary care with acute respiratory tract infection and cough: a prognostic cohort study. Lancet Respir Med. 2016.

Halliday J, Collins V, Riley M, Youssef D, Muggli E. Has prenatal screening influenced the prevalence of comorbidities associated with Down syndrome and subsequent survival rates? Pediatrics. 2009;123:256–61.

Elmagrpy Z, Rayani A, Shah A, Habas E, Aburawi EH. Down syndrome and congenital heart disease: why the regional difference as observed in the Libyan experience? Cardiovasc J Afr. 2011;22:306–9.

Bergstrom S, Carr H, Petersson G, Stephansson O, Bonamy AK, Dahlstrom A, Halvorsen CP, Johansson S. Trends in congenital heart defects in infants with down syndrome. Pediatrics 2016;138.

de Rubens FJ, del Pozzo MB, Pablos Hach JL, Calderón Jiménez C, Castrejón Urbina R. Heart malformations in children with down syndrome. Revista Española de Cardiologia. 2003;56:894–9.

Muñoz-López F. Pediatrics, Down’s syndrome and allergic disease. Int Med Rev Down Syndr. 2011;15:8–13.

Weijerman ME, Brand PL, van Furth MA, Broers CJ, Gemke RJ. Recurrent wheeze in children with down syndrome: is it asthma? Acta Paediatr. 2011;100:e194–e197197.

Little P, Stuart B, Andreou P, McDermott L, Joseph J, Mullee M, Moore M, Broomfield S, Thomas T, Yardley L. Primary care randomised controlled trial of a tailored interactive website for the self-management of respiratory infections (Internet Doctor). BMJ open. 2016;6:e009769.

Tutor JD, Gosa MM. Dysphagia and aspiration in children. Pediatr Pulmonol. 2012;47:321–37.

Ram G, Chinen J. Infections and immunodeficiency in Down syndrome. Clin Exp Immunol. 2011;164:9–16.

Bloemers BL, Broers CJ, Bont L, Weijerman ME, Gemke RJ, van Furth A. Increased risk of respiratory tract infections in children with Down syndrome: the consequence of an altered immune system. Microb ad Infect. 2010;12:799–808.

Kusters MAA, Verstegen RHJ, Gemen EFA, De Vries E. Intrinsic defect of the immune system in children with Down syndrome: a review. Clin Exp Immunol. 2009;156:189–93.

Bloemers BL, van Bleek GM, Kimpen JL, Bont L. Distinct abnormalities in the innate immune system of children with Down syndrome. J Pediatr. 2010;156:804–9.

Minnes P, Steiner K. Parent views on enhancing the quality of health care for their children with fragile X syndrome, autism or Down syndrome. Child Care Health Dev. 2009;35:250–6.

Tomita K, Sano H, Chiba Y, Sato R, Sano A, Nishiyama O, Iwanaga T, Higashimoto Y, Haraguchi R, Tohda Y. A scoring algorithm for predicting the presence of adult asthma: a prospective derivation study. Prim Care Respir J. 2013;22:51–8.

Hay AD, Birnie K, Busby J, Delaney B, Downing H, Dudley J, Durbaba S, Fletcher M, Harman K, Hollingworth W, et al. The diagnosis of urinary tract infection in young children (DUTY): a diagnostic prospective observational study to derive and validate a clinical algorithm for the diagnosis of urinary tract infection in children presenting to primary care with an acute illness. Health Technol Assess. 2016;20:1–294.

NICE: Amantadine, oseltamivir and zanamivir for the treatment of influenza. In: Technology appraisal guidance [TA168]. 2009.

Public Health England: PHE guidance on use of antivirals for the treatment and prophylaxis of influenza. In: Pandemic flu: public health response. 2014.

Marder L, Down’s syndrome medical interest group: immunisation: protecting people with Down’s syndrome against infection. In: 2014.