Resistance to the mTOR Inhibitor Temsirolimus Alters Adhesion and Migration Behavior of Renal Cell Carcinoma Cells through an Integrin α5– and Integrin β3–Dependent Mechanism

Neoplasia - Tập 16 - Trang 291-300 - 2014
Eva Juengel1, Jasmina Makarević1, Michael Reiter1, Jens Mani1, Igor Tsaur1, Georg Bartsch2, Axel Haferkamp1, Roman A. Blaheta1
1Department of Urology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany
2Department of Urology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany

Tài liệu tham khảo

Najjar, 2012, Novel agents in renal carcinoma: a reality check, Ther Adv Med Oncol, 4, 183, 10.1177/1758834012443725 Cho, 2012, Two phase 2 trials of the novel Akt inhibitor perifosine in patients with advanced renal cell carcinoma after progression on vascular endothelial growth factor-targeted therapy, Cancer, 118, 6055, 10.1002/cncr.27668 Pantuck, 2007, Prognostic relevance of the mTOR pathway in renal cell carcinoma: implications for molecular patient selection for targeted therapy, Cancer, 109, 2257, 10.1002/cncr.22677 Hutson, 2011, Targeted therapies for the treatment of metastatic renal cell carcinoma: clinical evidence, Oncologist, 16, 14, 10.1634/theoncologist.2011-S2-14 Rasmussen, 2011, Looking beyond inhibition of VEGF/mTOR: emerging targets for renal cell carcinoma drug development, Curr Clin Pharmacol, 6, 199, 10.2174/157488411797189389 Harada, 2013, Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2, Br J Cancer, 109, 2389, 10.1038/bjc.2013.602 Juengel, 2012, Acetylation of histone H3 prevents resistance development caused by chronic mTOR inhibition in renal cell carcinoma cells, Cancer Lett, 324, 83, 10.1016/j.canlet.2012.05.003 Tsaur, 2011, The cdk1-cyclin B complex is involved in everolimus triggered resistance in the PC3 prostate cancer cell line, Cancer Lett, 313, 84, 10.1016/j.canlet.2011.08.026 Knowles, 2013, Integrin αvβ3 and fibronectin upregulate Slug in cancer cells to promote clot invasion and metastasis, Cancer Res, 73, 6175, 10.1158/0008-5472.CAN-13-0602 Tsaur, 2012, Resistance to the mTOR-inhibitor RAD001 elevates integrin α2- and β1-triggered motility, migration and invasion of prostate cancer cells, Br J Cancer, 107, 847, 10.1038/bjc.2012.313 van Zijl, 2011, Initial steps of metastasis: cell invasion and endothelial transmigration, Mutat Res, 728, 23, 10.1016/j.mrrev.2011.05.002 Messai, 2010, Cytokeratin 18 expression pattern correlates with renal cell carcinoma progression: relationship with Snail, Int J Oncol, 36, 1145 Yilmaz, 2010, Mechanisms of motility in metastasizing cells, Mol Cancer Res, 8, 629, 10.1158/1541-7786.MCR-10-0139 Isogai, 2001, Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin, Cancer Res, 61, 5587 Jones, 2007, Transient down-regulation of beta1 integrin subtypes on kidney carcinoma cells is induced by mechanical contact with endothelial cell membranes, J Cell Mol Med, 11, 826, 10.1111/j.1582-4934.2007.00071.x Jones, 2007, CXCR4 chemokine receptor engagement modifies integrin dependent adhesion of renal carcinoma cells, Exp Cell Res, 313, 4051, 10.1016/j.yexcr.2007.07.001 Leroy-Dudal, 2005, Transmigration of human ovarian adenocarcinoma cells through endothelial extracellular matrix involves αv integrins and the participation of MMP2, Int J Cancer, 114, 531, 10.1002/ijc.20778 Heino, 2009, Cellular receptors of extracellular matrix molecules, Curr Pharm Des, 15, 1309, 10.2174/138161209787846720 Li, 2012, Down-regulation of β3-integrin inhibits bone metastasis of small cell lung cancer, Mol Biol Rep, 39, 3029, 10.1007/s11033-011-1065-y Liu, 2012, MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits, Nat Cell Biol, 14, 567, 10.1038/ncb2491 Lei, 2011, Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells, Mol Cell Proteomics, 10, 10.1074/mcp.M110.005397 Ahn, 2012, The metastasis gene NEDD9 product acts through integrin β3 and Src to promote mesenchymal motility and inhibit amoeboid motility, J Cell Sci, 125, 1814, 10.1242/jcs.101444 Bauer, 2007, Expression profiling reveals genes associated with transendothelial migration of tumor cells: a functional role for αvβ3 integrin, Int J Cancer, 121, 1910, 10.1002/ijc.22879 Jacquemet, 2013, Role of adhesion receptor trafficking in 3D cell migration, Curr Opin Cell Biol, 25, 627, 10.1016/j.ceb.2013.05.008 Flevaris, 2007, A molecular switch that controls cell spreading and retraction, J Cell Biol, 179, 553, 10.1083/jcb.200703185 Jeruschke, 2013, Protective effects of the mTOR inhibitor everolimus on cytoskeletal injury in human podocytes are mediated by RhoA signaling, PLoS One, 8, e55980, 10.1371/journal.pone.0055980 Goundiam, 2012, Akt and RhoA inhibition promotes anoikis of aggregated B16F10 melanoma cells, Cell Biol Int, 36, 311, 10.1042/CBI20110069