Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib

New England Journal of Medicine - Tập 370 Số 24 - Trang 2286-2294 - 2014
Jennifer A. Woyach1, Richard R. Furman2, Ta-Ming Liu1, Hatice Gülçin Özer3, Marc Zapatka4, Amy S. Ruppert1, Ling Xue5, Daniel Hsieh-Hsin Li5, Susanne Steggerda5, Matthias Versele6, Sandeep S. Davé7, Jenny Zhang7, Ayse Selen Yilmaz3, Samantha Jaglowski1, Kristie A. Blum1, Arletta Lozanski1, Gerard Lozanski8, Danelle F. James5, Jacqueline C. Barrientos9, Peter Lichter4, Stephan Stilgenbauer10, Joseph J. Buggy5, Betty Chang5, Amy J. Johnson1, John C. Byrd1
1Division of Hematology, Department of Internal Medicine
2Department of Medicine, Division of Hematology–Oncology, Weill Cornell Medical College, New York
3Department of Biomedical Informatics;
4Division of Molecular Genetics, German Cancer Research Center, Heidelberg
5Pharmacyclics, Sunnyvale, CA
6Janssen Research and Development, Beerse, Belgium
7Duke Cancer Institute, Duke University, Durham, NC
8Department of Pathology, Ohio State University, Columbus
9Division of Hematology–Oncology, Department of Medicine, Hofstra North Shore–LIJ School of Medicine, New Hyde Park, NY
10Department of Internal Medicine III, University of Ulm, Ulm

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