Resection margins and other prognostic factors regarding surgically treated glottic carcinomas

Journal of Surgical Oncology - Tập 101 Số 2 - Trang 131-136 - 2010
Alexander D. Karatzanis1,2,3, Frank Waldfahrer1,3, Georgios Psychogios3,4, Joachim Hornung1,3, Johannes Zenk3,5, George A. Velegrakis2,6, Heinrich Iro3,6
1Attending Otorhinolaryngologist.
2Department of Otorhinolaryngology, Head and Neck Surgery, University of Crete Medical School, Heraklion, Crete, Greece
3Department of Otorhinolaryngology, Head and Neck Surgery, University of Erlangen-Nuremberg Medical School, Erlangen, Germany
4ENT Resident
5Professor
6Professor and Chairman

Tóm tắt

AbstractBackground and ObjectivesThis study aims to assess the prognostic significance of free histopathologic margins in the surgical treatment of glottic cancer. Furthermore, it evaluates other prognostic factors regarding cases that receive surgical management for glottic lesions.MethodsA retrospective case‐series study was conducted at an academic tertiary referral center. The files of 1,314 cases that underwent primary surgical treatment for glottic cancer were studied. Various prognostic factors, including age, surgical procedure, T classification, N classification, histological grade, and status of margins were assessed in univariate and multivariate analyses. All variables were investigated for their association with local and regional disease control as well as disease specific and overall survival.ResultsStatus of margins significantly affected disease specific survival and local control regardless of tumor stage in this series. All other variables assessed in the univariate analysis for their association with survival were also found to be significant. However, status of surgical margins and N classification were the only significant variables in multivariate analysis.ConclusionThe prognostic value of negative surgical margins for the treatment of glottic cancer cannot be overestimated. Responsibility of the surgeon during primary surgical treatment of glottic carcinomas is emphasized. J. Surg. Oncol. 2010;101:131–136. © 2009 Wiley‐Liss, Inc.

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Tài liệu tham khảo

10.1016/j.otc.2008.01.016

10.1001/archotol.131.1.21

10.1016/j.otc.2008.01.018

10.1016/j.otc.2008.01.014

10.1016/j.otc.2008.01.020

10.1097/01.mlg.0000251165.48830.89

10.1177/000348948809700223

10.1001/archotol.124.11.1245

10.1016/S0360-3016(00)00514-9

10.1097/00005537-200404000-00005

10.1007/978-1-4757-3656-4_5

10.1017/S0022215100078130

10.1016/j.otc.2008.02.001

10.1001/archotol.132.2.147

10.1097/01.mlg.0000236095.97947.26

10.1007/s004050100325

Steiner W, 1988, Experience in endoscopic surgery of malignant tumors of the upper aerodigestive tract, Adv Otorhinolaryngol, 39, 135

10.1016/j.otohns.2007.12.046

Eibling DE, 1997, Operative otolaryngology, head and neck surgery, 416

10.1097/01.mlg.0000184767.62682.3d

10.1001/archotol.133.9.882

10.1097/MLG.0b013e318175338f

Lee JG, 1974, Detection of residual carcinoma of the oral cavity, oropharynx, hypopharynx and larynx: A study of surgical margins, Trans Am Acad Opthalmol Otolaryngol, 78, 49

10.1288/00005537-199301000-00012

10.1067/mhn.2000.105062

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Thông tin xuất bản

Journal of Surgical Oncology

Tập 101 Số 2

131-136

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