Research frontiers highlighted in Science China Life Sciences in 2009

Wang D C. Message from the Editor-in-Chief. Sci China Ser C-Life Sci, 2009, 52: 1 Chen Z, Zhao G P. Human genomics in China—ten years endeavor: From planning to implementation. Sci China Ser C-Life Sci, 2009, 52: 2–6 Qu L H. RNomics: The new frontier in the post-genomic era. Sci China Ser C-Life Sci, 2009, 52: 193–194 Xu R M. Molecular epigenetics: Dawn of a new era of biomedical research. Sci China Ser C-Life Sci, 2009, 52: 309–310 Gao G F, Shaw P C. The challenges of avian influenza virus: Mechanism, epidemiology and control. Sci China Ser C-Life Sci, 2009, 52: 405–406 Jiang C Y. Stem cell research: From molecular physiology to therapeutic applications. Sci China Ser C-Life Sci, 2009, 52: 597–598 Chang Z Y. The CUSBEA Program: Twenty years after. IUBMB Life, 2009, 61: 555–565 Jiang C Y. Commemorating the life of a legend. Sci China Ser C-Life Sci, 2009, 52: 97–98 The International Human Genome Sequencing Consortium. Initial sequencing and analysis of the human genome. Nature, 2001, 409: 860–921 Yu J, Hu S L, Wang J, et al. A draft sequence of the rice genome (Oryza sativa L. ssp. Indica). Science, 2002, 296: 79–92 Teng X K, Xiao H S. Perspectives of DNA microarray and next-generation DNA sequencing technologies. Sci China Ser C-Life Sci, 2009, 52: 7–16 Shi J X, Wang Y, Huang W. Development and application of genotyping technologies. Sci China Ser C-Life Sci, 2009, 52: 17–23 Han Z G. Recent progress in genomic research of liver cancer. Sci China Ser C-Life Sci, 2009, 52: 24–30 Huang J. Current progress in epigenetic research for heterocarcinomagenesis. Sci China Ser C-Life Sci, 2009, 52: 31–42 Li H W, Li J Z, Zhao G P, et al. Current research status of immunology in the genomic era. Sci China Ser C-Life Sci, 2009, 52: 43–49 Yang R F, Guo X K, Yang J, et al. Genomic research for important pathogenic bacteria in China. Sci China Ser C-Life Sci, 2009, 52: 50–63 Wang L, Liu B, Zhou Z M. Research progress in genomics of environmental and industrial microorganisms. Sci China Ser C-Life Sci, 2009, 52: 64–73 Lee R C, Feinbaum R L, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 1993, 75: 843–854 Bartel D P. MicroRNAs: Target recognition and regulatory functions. Cell, 2009, 136: 215–233 Zhang Y J, Qu L H. Non-coding RNAs and the acquisition of genomic imprinting in mammals. Sci China Ser C-Life Sci, 2009, 52: 195–204 Shi Y, Jin Y X. MicroRNA in cell differentiation and development. Sci China Ser C-Life Sci, 2009, 52: 205–211 Mao Y B, Xue X Y, Chen X Y. Are small RNAs a big help to plants? Sci China Ser C-Life Sci, 2009, 52: 212–223 Zhang H, Chen Y Q. New insight into the role of miRNAs in leukemia. Sci China Ser C-Life Sci, 2009, 52: 224–231 Zhang Y F, Zhang R, Su B. Diversity and evolution of microRNA gene clusters. Sci China Ser C-Life Sci, 2009, 52: 261–266 Wu Q J, Huang L, Zhang Y. The structure and function of catalytic RNAs. Sci China Ser C-Life Sci, 2009, 52: 232–244 Li Y, Zhou H. tRNAs as regulators in gene expression. Sci China Ser C-Life Sci, 2009, 52: 245–252 Hui J Y. Regulation of mammalian pre-mRNA splicing. Sci China Ser C-Life Sci, 2009, 52: 253–260 Lan F, Shi Y. Epigenetic regulation: Methylation of histone and non-histone proteins. Sci China Ser C-Life Sci, 2009, 52: 311–322 Ma C, Liu Y F, He L. microRNAs—powerful repression comes from small RNAs. Sci China Ser C-Life Sci, 2009, 52: 323–330 Chinnusamy V, Zhu J K. RNA-directed DNA methylation and demethylation in plants. Sci China Ser C-Life Sci, 2009, 52: 331–343 Xu C L, Dong L B, Xin L, et al. Human avian influenza A (H5N1) virus infection in China. Sci China Ser C-Life Sci, 2009, 52: 407–411 Chen H L. H5N1 avian influenza in China. Sci China Ser C-Life Sci, 2009, 52: 419–427 Chan P K S. A review on human influenza A H5N1 infections in Hong Kong. Sci China Ser C-Life Sci, 2009, 52: 412–418 Liu D, Liu X L, Yan J H, et al. Interspecies transmission and host restriction of avian H5N1 influenza virus. Sci China Ser C-Life Sci, 2009, 52: 428–438 Ng A K L, Wang J H, Shaw P C. Structure and sequence analysis of influenza A virus nucleoprotein. Sci China Ser C-Life Sci, 2009, 52: 439–449 Liu Y F, Lou Z Y, Bartlam M, et al. Structure-function studies of the influenza virus RNA polymerase PA subunit. Sci China Ser C-Life Sci, 2009, 52: 450–458 Wang H L, Jiang C Y. Avian influenza H5N1: An update on molecular pathogenesis. Sci China Ser C-Life Sci, 2009, 52: 459–463 Wang H L, Jiang C Y. Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis. Sci China Ser C-Life Sci, 2009, 52: 464–469 Liu D, Liu Q H, Wu L H, et al. Website for avian flu information and bioinformatics. Sci China Ser C-Life Sci, 2009, 52: 470–473 Hao J, Zhu W W, Sheng C, et al. Human parthenogenetic embryonic stem cells: One potential resource for cell therapy. Sci China Ser C-Life Sci, 2009, 52: 599–602 Wang L, Zhao R C H. Mesenchymal stem cells targeting the GVHD. Sci China Ser C-Life Sci, 2009, 52: 603–609 Ren Z H, Zhang Y. Cells therapy for Parkinson’s disease-so close and so far away. Sci China Ser C-Life Sci, 2009, 52: 610–614 Zhang D H, Jiang W, Shi Y, et al. Generation of pancreatic islet cells from human embryonic stem cells. Sci China Ser C-Life Sci, 2009, 52: 615–621 Chen L Y, Liu L. Current progress and prospects of induced pluripotent stem cells. Sci China Ser C-Life Sci, 2009, 52: 622–636 Editorial. Ray Wu, Cornell’s acclaimed pioneer of genetic engineering and developer of insect-resistant rice. Sci China Ser C-Life Sci, 2009, 52: 99–100 Wu A W, Wu C C, Sugg D K. Ray Wu’s golden rules: How he achieved greatness in work and in life. Sci China Ser C-Life Sci, 2009, 52: 101–107 Szostak J. Ray Wu, as remembered by a former student. Sci China Ser C-Life Sci, 2009, 52: 108–110 Wu A S H. Eight lucky lessons learned. Sci China Ser C-Life Sci, 2009, 52: 111–114 Wu C W M. Remembering Ray. Sci China Ser C-Life Sci, 2009, 52: 115–117 Li P. In memory of Dr. Ray Wu. Sci China Ser C-Life Sci, 2009, 52: 118 Shen Y F. The China affection of Ray Wu. Sci China Ser C-Life Sci, 2009, 52: 119–124 Gu X C. Ray Wu and the CUSBEA Program. Sci China Ser C-Life Sci, 2009, 52: 125–127 Yang N S, Lan C W. For our founding father of ABRC, Prof. Ray Wu (1928–2008). Sci China Ser C-Life Sci, 2009, 52: 128–129 Shi Y G. Ray Wu: United we prevail. Sci China Ser C-Life Sci, 2009, 52: 130–132 Tye B K. Memories of Ray Wu by a colleague. Sci China Ser C-Life Sci, 2009, 52: 133–134 Shi Y G. Assembly and structure of protein phosphatase 2A. Sci China Ser C-Life Sci, 2009, 52: 135–146