Reproducibility of Interfraction Lung Motion Probability Distribution Function Using Dynamic MRI: Statistical Analysis

International Commission on Radiation Units and Measurements, 1999 Biancia, 2005, Comparison of end normal inspiration and expiration for gated intensity modulated radiation therapy (IMRT) of lung cancer, Radiother Oncol, 75, 149, 10.1016/j.radonc.2005.01.008 Berbeco, 2005, Residual motion of lung tumours in gated radiotherapy with external respiratory surrogates, Phys Med Biol, 50, 3655, 10.1088/0031-9155/50/16/001 Kubo, 1999, Potential and role of a prototype amorphous silicon array electronic portal imaging device in breathing synchronized radiotherapy, Med Phys, 26, 2410, 10.1118/1.598758 Hanley, 1999, Deep inspiration breath-hold technique for lung tumors: the potential value of target immobilization and reduced lung density in dose escalation, Int J Radiat Oncol Biol Phys, 45, 603, 10.1016/S0360-3016(99)00154-6 Ramsey, 1999, Clinical efficacy of respiratory gated conformal radiation therapy, Med Dosim, 24, 115, 10.1016/S0958-3947(99)00006-0 Nehmeh, 2004, Four-dimensional (4D) PET/CT imaging of the thorax, Med Phys, 31, 3179, 10.1118/1.1809778 Keall, 2004, Acquiring 4D thoracic CT scans using a multislice helical method, Phys Med Biol, 49, 2053, 10.1088/0031-9155/49/10/015 Pan, 2004, 4D-CT imaging of a volume influenced by respiratory motion on multi-slice CT, Med Phys, 31, 333, 10.1118/1.1639993 Endo, 2003, Four-dimensional computed tomography (4D CT)—Concepts and preliminary development, Radiat Med, 21, 17 Ichikawa, 2000, 4D-CT: A new development in three-dimensional hepatic computed tomography, J Nippon Med Sch, 67, 24, 10.1272/jnms.67.24 Sheng, 2006, A computer simulated phantom study of tomotherapy dose optimization based on probability density functions (PDF) and potential errors caused by low reproducibility of PDF, Med Phys, 33, 3321, 10.1118/1.2222331 Trofimov, 2005, Temporo-spatial IMRT optimization: Concepts, implementation and initial results, Phys Med Biol, 50, 2779, 10.1088/0031-9155/50/12/004 Unkelbach, 2004, Inclusion of organ movements in IMRT treatment planning via inverse planning based on probability distributions, Phys Med Biol, 49, 4005, 10.1088/0031-9155/49/17/013 Unkelbach, 2005, Incorporating organ movements in inverse planning: Assessing dose uncertainties by Bayesian inference, Phys Med Biol, 50, 121, 10.1088/0031-9155/50/1/010 Cai, 2007, Evaluation of the reproducibility of lung motion probability distribution function (PDF) using dynamic MRI, Phys Med Biol, 52, 365, 10.1088/0031-9155/52/2/004 Koch, 2004, Evaluation of internal lung motion for respiratory-gated radiotherapy using MRI: Part I—Correlating internal lung motion with skin fiducial motion, Int J Radiat Oncol Biol Phys, 60, 1459, 10.1016/j.ijrobp.2004.05.055 Liu, 2004, Evaluation of internal lung motion for respiratory-gated radiotherapy using MRI: Part II—Margin reduction of internal target volume, Int J Radiat Oncol Biol Phys, 60, 1473, 10.1016/j.ijrobp.2004.05.054 Ohno, 2002, Solitary pulmonary nodules: Potential role of dynamic MR imaging in management initial experience, Radiology, 224, 503, 10.1148/radiol.2242010992 Plathow, 2004, Analysis of intrathoracic tumor mobility during whole breathing cycle by dynamic MRI, Int J Radiat Oncol Biol Phys, 59, 952, 10.1016/j.ijrobp.2003.12.035 Shimizu, 2000, High-speed magnetic resonance imaging for four-dimensional treatment planning of conformal radiotherapy of moving body tumors, Int J Radiat Oncol Biol Phys, 48, 471, 10.1016/S0360-3016(00)00624-6 Cai, 2007, Estimation of error in maximal intensity projection-based internal target volume of lung tumors: a simulation and comparison study using dynamic magnetic resonance imaging, Int J Radiat Oncol Biol Phys, 69, 895, 10.1016/j.ijrobp.2007.07.2322 Nishioka, 2008, Exhale fluctuation in respiratory-gated radiotherapy of the lung: A pitfall of respiratory gating shown in a synchronized internal/external marker recording study, Radiother Oncol, 86, 69, 10.1016/j.radonc.2007.11.014 George, 2005, Is the diaphragm motion probability density function normally distributed?, Med Phys, 32, 396, 10.1118/1.1845031 Timmerman, 2007, Stereotactic body radiation therapy in multiple organ sites, J Clin Oncol, 25, 947, 10.1200/JCO.2006.09.7469 Shirato, 2006, Speed and amplitude of lung tumor motion precisely detected in four-dimensional setup and in real-time tumor-tracking radiotherapy, Int J Radiat Oncol Biol Phys, 64, 1229, 10.1016/j.ijrobp.2005.11.016 George, 2006, Investigation of patient, tumour and treatment variables affecting residual motion for respiratory-gated radiotherapy, Phys Med Biol, 51, 5305, 10.1088/0031-9155/51/20/015 Neicu, 2006, Synchronized moving aperture radiation therapy (SMART): Improvement of breathing pattern reproducibility using respiratory coaching, Phys Med Biol, 51, 617, 10.1088/0031-9155/51/3/010 Cui, 2007, Multiple template-based fluoroscopic tracking of lung tumor mass without implanted fiducial markers, Phys Med Biol, 52, 6229, 10.1088/0031-9155/52/20/010 Willoughby, 2006, Target localization and real-time tracking using the Calypso 4D localization system in patients with localized prostate cancer, Int J Radiat Oncol Biol Phys, 65, 528, 10.1016/j.ijrobp.2006.01.050 Cai, 2007, MR grid-tagging using hyperpolarized helium-3 for regional quantitative assessment of pulmonary biomechanics and ventilation, Magn Reson Med, 58, 373, 10.1002/mrm.21288 Cai, 2007, Direct measurement of lung motion using hyperpolarized helium-3 MR tagging, Int J Radiat Oncol Biol Phys, 68, 650, 10.1016/j.ijrobp.2007.02.011 Seppenwoolde, 2002, Precise and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy, Int J Radiat Oncol Biol Phys, 53, 822, 10.1016/S0360-3016(02)02803-1