Reporter gene assays for investigating GPCR signaling

Balenga, 2017, Orphan adhesion GPCR GPR64/ADGRG2 is overexpressed in parathyroid tumors and attenuates calcium-sensing receptor-mediated signaling, Journal of Bone and Mineral Research, 32, 654, 10.1002/jbmr.3023 Fan, 2007, Bioluminescent assays for high-throughput screening, Assay and Drug Development Technologies, 5, 127, 10.1089/adt.2006.053 Gutkind, 2000, Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors, Science's STKE, 2000, re1, 10.1126/stke.2000.40.re1 Henstridge, 2010, GPR55 ligands promote receptor coupling to multiple signalling pathways, British Journal of Pharmacology, 160, 604, 10.1111/j.1476-5381.2009.00625.x Levoye, 2008, Alternative drug discovery approaches for orphan GPCRs, Drug Discovery Today, 13, 52, 10.1016/j.drudis.2007.09.011 Reiter, 2012, Molecular mechanism of beta-arrestin-biased agonism at seven-transmembrane receptors, Annual Review of Pharmacology and Toxicology, 52, 179, 10.1146/annurev.pharmtox.010909.105800 Shenoy, 2005, Seven-transmembrane receptor signaling through beta-arrestin, Science's STKE, 2005, cm10, 10.1126/stke.2005/308/cm10 Wu, 2001, Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway, Proceedings of the National Academy of Sciences of the United States of America, 98, 2808, 10.1073/pnas.051634198