Reply to letter to editor regarding: LHRH analog therapy is associated with worse metabolic side effects than bilateral orchiectomy in prostate cancer

Vargas A, Machado RD, Filho DI, Paiva CE, Dos Reis RB, Tobias-Machado M et al (2016) LHRH analog therapy is associated with worse metabolic side effects than bilateral orchiectomy in prostate cancer. World J Urol 34(12):1621–1628 Ostergren PB, Klausen TW, Fode M (2017) No convincing evidence on differences in metabolic effects of medical and surgical castration in the treatment of prostate cancer. World J Urol. https://doi.org/10.1007/s00345-017-2012-x Timilshina N, Hussain S, Breunis H, Alibhai SM (2011) Predictors of hemoglobin decline in non-metastatic prostate cancer patients on androgen deprivation therapy: a matched cohort study. Support Care Cancer 19(11):1815–1821 Hara N, Nishiyama T, Takizawa I, Saito T, Kitamura Y, Takahashi K (2010) Decline of the red blood cell count in patients receiving androgen deprivation therapy for localized prostate cancer: impact of ADT on insulin-like growth factor-1 and erythropoiesis. Urology. 75(6):1441–1445 Sun M, Choueiri TK, Hamnvik OP, Preston MA, De Velasco G, Jiang W et al (2016) Comparison of gonadotropin-releasing hormone agonists and orchiectomy: effects of androgen-deprivation therapy. JAMA Oncol 2(4):500–507 Chen DY, See LC, Liu JR, Chuang CK, Pang ST, Hsieh IC et al (2017) Risk of cardiovascular ischemic events after surgical castration and gonadotropin-releasing hormone agonist therapy for prostate cancer: a nationwide cohort study. J Clin Oncol 35(32):3697–3705 Bayoumi AM, Brown AD, Garber AM (2000) Cost-effectiveness of androgen suppression therapies in advanced prostate cancer. J Natl Cancer Inst 92(21):1731–1739 Seidenfeld J, Samson DJ, Aronson N, Albertson PC, Bayoumi AM, Bennett C et al (1999) Relative effectiveness and cost-effectiveness of methods of androgen suppression in the treatment of advanced prostate cancer. Evid Rep/Technol Assess (Summary). 4:i-x Clinical Trials website search. https://clinicaltrials.gov/ct2/results?cond=Prostate+Cancer&term=metabolic+syndrome%2C+orquiectomy%2C+analogue%2C+hormonal&cntry=&state=&city=&dist=