Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway
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Schmidtke, 2010, WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations, Hum Genet, 128, 103, 10.1007/s00439-010-0832-5
Goto, 1997, Hierarchical deterioration of body systems in Werner's syndrome: implications for normal ageing, Mech Ageing Dev, 98, 239, 10.1016/S0047-6374(97)00111-5
Martin, 1981, Cytogenetics of Werner's syndrome cultured skin fibroblasts: variegated translocation mosaicism, Cytogenet Cell Genet, 30, 92, 10.1159/000131596
Monnat, 1989, Mutator phenotype of Werner syndrome is characterized by extensive deletions, Proc Natl Acad Sci U S A, 86, 5893, 10.1073/pnas.86.15.5893
Rabinovitch, 1999, Werner syndrome lymphoblastoid cells are sensitive to camptothecin-induced apoptosis in S-phase, Hum Genet, 104, 10, 10.1007/s004390050903
Rabinovitch, 2002, Werner syndrome diploid fibroblasts are sensitive to 4-nitroquinoline-N-oxide and 8-methoxypsoralen: implications for the disease phenotype, Faseb J, 16, 757, 10.1096/fj.01-0906fje
Palitti, 2001, Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle, Mol Biol Cell, 12, 2412, 10.1091/mbc.12.8.2412
Martin, 1992, Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines, Exp Cell Res, 202, 267, 10.1016/0014-4827(92)90074-I
Monnat, 2008, The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest, Cell Cycle, 7, 796, 10.4161/cc.7.6.5566
Cox, 2002, Asymmetry of DNA replication fork progression in Werner's syndrome, Aging Cell, 1, 30, 10.1046/j.1474-9728.2002.00002.x
Asaithamby, 2014, Nonenzymatic Role for WRN in Preserving Nascent DNA Strands after Replication Stress, Cell reports, 9, 1387, 10.1016/j.celrep.2014.10.025
Campisi, 1998, The premature ageing syndrome protein, WRN, is a 3′-->5′ exonuclease, Nat Genet, 20, 114, 10.1038/2410
Bohr, 2003, Werner syndrome protein contains three structure-specific DNA binding domains, J Biol Chem, 278, 52997, 10.1074/jbc.M308338200
Bohr, 2003, Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process, Carcinogenesis, 24, 791, 10.1093/carcin/bgg034
Bohr, 2001, Coordinate action of the helicase and 3′ to 5′ exonuclease of Werner syndrome protein, J Biol Chem, 276, 44677, 10.1074/jbc.M107548200
Chen, 2010, WRN participates in translesion synthesis pathway through interaction with NBS1, Mech Ageing Dev, 131, 436, 10.1016/j.mad.2010.06.005
Bohr, 2004, Linkage between Werner syndrome protein and the Mre11 complex via Nbs1, J Biol Chem, 279, 21169, 10.1074/jbc.M312770200
Bohr, 2006, Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest, J Cell Sci, 119, 5137, 10.1242/jcs.03291
Shimamoto, 2001, Werner helicase relocates into nuclear foci in response to DNA damaging agents and co-localizes with RPA and Rad51, Genes Cells, 6, 421, 10.1046/j.1365-2443.2001.00433.x
Cooper, 2011, The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome, Cell Cycle, 10, 1998, 10.4161/cc.10.12.15878
Bohr, 2010, Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases, DNA Repair (Amst), 9, 636, 10.1016/j.dnarep.2010.02.012
Cox, 2003, Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA, Mech Ageing Dev, 124, 167, 10.1016/S0047-6374(02)00131-8
Chen, 2001, Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase, J Biol Chem, 276, 38242, 10.1074/jbc.M101913200
Bohr, 2002, Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation, J Biol Chem, 277, 18291, 10.1074/jbc.M111523200
Bohr, 2007, The role of WRN in DNA repair is affected by post-translational modifications, Mech Ageing Dev, 128, 50, 10.1016/j.mad.2006.11.010
Pichierri, 2010, ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery, EMBO J, 29, 3156, 10.1038/emboj.2010.205
Franchitto, 2003, Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle, Oncogene, 22, 1491, 10.1038/sj.onc.1206169
Bohr, 2014, Serines 440 and 467 in the Werner syndrome protein are phosphorylated by DNA-PK and affects its dynamics in response to DNA double strand breaks, Aging (Albany NY), 6, 70
Franchitto, 2014, Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress, Nucleic acids research, 42, 12628, 10.1093/nar/gku1022
Luo, 2008, Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation, The Journal of biological chemistry, 283, 7590, 10.1074/jbc.M709707200
Luo, 2010, Acetylation of WRN protein regulates its stability by inhibiting ubiquitination, PLoS One, 5, e10341, 10.1371/journal.pone.0010341
Qin, 1998, Identification of phosphorylation sites in proteins separated by polyacrylamide gel electrophoresis, Analytical chemistry, 70, 2050, 10.1021/ac971207m
Marchand, 2010, DNA topoisomerases and their poisoning by anticancer and antibacterial drugs, Chem Biol, 17, 421, 10.1016/j.chembiol.2010.04.012
Pommier, 2006, Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks, J Biol Chem, 281, 30814, 10.1074/jbc.M603747200
Abraham, 1999, Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine, Cancer Res, 59, 4375
Smith, 2004, Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM, Cancer Res, 64, 9152, 10.1158/0008-5472.CAN-04-2727
Smith, 2004, Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries, Bioorg Med Chem Lett, 14, 6083, 10.1016/j.bmcl.2004.09.060
Chen, 2009, Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation, Nucleic Acids Res, 37, 3912, 10.1093/nar/gkp237
Chen, 2011, Unrepaired clustered DNA lesions induce chromosome breakage in human cells, Proc Natl Acad Sci U S A, 108, 8293, 10.1073/pnas.1016045108
Banath, 1991, DNA double-strand breaks measured in individual cells subjected to gel electrophoresis, Cancer Res, 51, 4671
Lambert, 2013, Replication stress-induced genome instability: the dark side of replication maintenance by homologous recombination, J Mol Biol, 425, 4733, 10.1016/j.jmb.2013.04.023
Chen, 2004, Human Rad51C deficiency destabilizes XRCC3, impairs recombination, and radiosensitizes S/G2-phase cells, J Biol Chem, 279, 42313, 10.1074/jbc.M405212200
Huang, 2015, ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress, Mol Cell, 58, 323, 10.1016/j.molcel.2015.02.031
Mayer, 2005, Ubiquitin and ubiquitin-like proteins as multifunctional signals, Nature reviews Molecular cell biology, 6, 599, 10.1038/nrm1700
Monnat, 2002, Homologous recombination resolution defect in Werner syndrome, Mol Cell Biol, 22, 6971, 10.1128/MCB.22.20.6971-6978.2002
Sidorova, 2008, Roles of the Werner syndrome RecQ helicase in DNA replication, DNA Repair (Amst), 7, 1776, 10.1016/j.dnarep.2008.07.017
Hickson, 2007, BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges, EMBO J, 26, 3397, 10.1038/sj.emboj.7601777
Chang, 1987, Microtubules containing acetylated alpha-tubulin in mammalian cells in culture, J Cell Biol, 104, 289, 10.1083/jcb.104.2.289
Asaithamby, 2015, FANCD2 influences replication fork processes and genome stability in response to clustered DSBs, Cell Cycle, 14, 1809, 10.1080/15384101.2015.1036210
Chen, 2007, Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks, J Cell Biol, 177, 219, 10.1083/jcb.200608077
Lees-Miller, 2006, DNA-PK autophosphorylation facilitates Artemis endonuclease activity, EMBO J, 25, 3880, 10.1038/sj.emboj.7601255
Tainer, 2010, Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex, J Biol Chem, 285, 1414, 10.1074/jbc.M109.065615
Pichierri, 2008, Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway, J Cell Biol, 183, 241, 10.1083/jcb.200803173
Ulrich, 2014, Two-way communications between ubiquitin-like modifiers and DNA, Nature structural & molecular biology, 21, 317, 10.1038/nsmb.2805
Helleday, 2010, Pathways of mammalian replication fork restart, Nat Rev Mol Cell Biol, 11, 683, 10.1038/nrm2974
Stark, 2011, The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation, Nucleic Acids Res, 39, 5935, 10.1093/nar/gkr187
Pellman, 2009, A mechanism linking extra centrosomes to chromosomal instability, Nature, 460, 278, 10.1038/nature08136
Kowalczykowski, 2010, Purified human BRCA2 stimulates RAD51-mediated recombination, Nature, 467, 678, 10.1038/nature09399
Heyer, 2010, Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA, Nat Struct Mol Biol, 17, 1260, 10.1038/nsmb.1904
Thacker, 2000, Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation, Nat Cell Biol, 2, 757, 10.1038/35036399
Larson, 2008, DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome, Nature, 456, 66, 10.1038/nature07485
Monnat, 2013, Spectrum and risk of neoplasia in Werner syndrome: a systematic review, PLoS One, 8, e59709, 10.1371/journal.pone.0059709
O'Driscoll, 2009, Human DNA damage response and repair deficiency syndromes: linking genomic instability and cell cycle checkpoint proficiency, DNA Repair (Amst), 8, 1139, 10.1016/j.dnarep.2009.04.018
Durandy, 2013, Primary microcephaly, impaired DNA replication, and genomic instability caused by compound heterozygous ATR mutations, Hum Mutat, 34, 374, 10.1002/humu.22245
Brown, 2007, Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss, Cell stem cell, 1, 113, 10.1016/j.stem.2007.03.002
Fernandez-Capetillo, 2009, A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging, Nat Genet, 41, 891, 10.1038/ng.420
O'Driscoll, 2009, Mouse models for ATR deficiency, DNA Repair (Amst), 8, 1333, 10.1016/j.dnarep.2009.09.001