Replication of CNTNAP2 association with nonword repetition and support for FOXP2 association with timed reading and motor activities in a dyslexia family sample

Springer Science and Business Media LLC - Tập 3 Số 1 - Trang 39-49 - 2011
Beate Peter1, Wendy H. Raskind2, Mark Matsushita2, Mark Lisowski2, Tiffany Vu2, Virginia W. Berninger3, Ellen M. Wijsman4, Zoran Brkanac5
1Department of Speech and Hearing Sciences, University of Washington, P.O. Box 354875, Seattle, WA, 98195, USA
2Department of Medicine, University of Washington, P.O. Box 354875, Seattle, WA, 98195, USA
3Department of Educational Psychology, University of Washington, P.O. Box 354875, Seattle, WA, 98195, USA
4Department of Biostatistics, University of Washington, P.O. Box 354875, Seattle, WA, 98195, USA
5Department of Psychiatry and Behavioral Sciences, University of Washington, P.O. Box 354875, Seattle, WA, 98195, USA

Tóm tắt

Abstract Two functionally related genes, FOXP2 and CNTNAP2, influence language abilities in families with rare syndromic and common nonsyndromic forms of impaired language, respectively. We investigated whether these genes are associated with component phenotypes of dyslexia and measures of sequential motor ability. Quantitative transmission disequilibrium testing (QTDT) and linear association modeling were used to evaluate associations with measures of phonological memory (nonword repetition, NWR), expressive language (sentence repetition), reading (real word reading efficiency, RWRE; word attack, WATT), and timed sequential motor activities (rapid alternating place of articulation, RAPA; finger succession in the dominant hand, FS-D) in 188 family trios with a child with dyslexia. Consistent with a prior study of language impairment, QTDT in dyslexia showed evidence of CNTNAP2 single nucleotide polymorphism (SNP) association with NWR. For FOXP2, we provide the first evidence for SNP association with component phenotypes of dyslexia, specifically NWR and RWRE but not WATT. In addition, FOXP2 SNP associations with both RAPA and FS-D were observed. Our results confirm the role of CNTNAP2 in NWR in a dyslexia sample and motivate new questions about the effects of FOXP2 in neurodevelopmental disorders.

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