Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)

AIDS - Tập 21 Số 8 - Trang 1043-1045 - 2007
Aurélia Lamine1, Anne Caumont‐Sarcos2, Marie‐Laure Chaix3, Asier Sáez‐Cirión4, Christine Katlama3, Jean‐François Delfraissy5,1, Gianfranco Pancino4, Olivier Schwartz5,1
1INSERM U802, Paris XI University, Bicêtre, France
2CNRS-UMR 5097 Laboratory, Bordeaux 2 University, Bordeaux, France
3Laboratory of Virology, EA MRT CHU Necker, Paris, France
4Regulation of Retroviral Infections Unit, Institut Pasteur, Paris, France
5Department of Internal Medicine and Infectious Diseases, Bicêtre Hospital, Bicêtre, France.

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Tài liệu tham khảo

Cao, 1995, Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection, N Engl J Med, 332, 201, 10.1056/NEJM199501263320401

Bailey, 2006, Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations, J Exp Med, 203, 1357, 10.1084/jem.20052319

Lambotte, 2005, HIV controllers: a homogeneous group of HIV-1-infected patients with spontaneous control of viral replication, Clin Infect Dis, 41, 1053, 10.1086/433188

Migueles, 2002, HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors, Nat Immunol, 3, 1061, 10.1038/ni845

Migueles, 2000, HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors, Proc Natl Acad Sci U S A, 97, 2709, 10.1073/pnas.050567397

Kloosterboer, 2005, Natural controlled HIV infection: preserved HIV-specific immunity despite undetectable replication competent virus, Virology, 339, 70, 10.1016/j.virol.2005.06.001

Wang, 2003, First demonstration of a lack of viral sequence evolution in a nonprogressor, defining replication-incompetent HIV-1 infection, Virology, 12, 135, 10.1016/S0042-6822(03)00159-4

Lum, 2003, Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis, J Clin Invest, 111, 1547, 10.1172/JCI16233

Mologni, 2006, Vpr and HIV-1 disease progression: R77Q mutation is associated with long-term control of HIV-1 infection in different groups of patients, AIDS, 20, 567, 10.1097/01.aids.0000210611.60459.0e

Candotti, 1999, Status of long-term asymptomatic HIV-1 infection correlates with viral load but not with virus replication properties and cell tropism. French ALT Study Group, J Med Virol, 58, 256, 10.1002/(SICI)1096-9071(199907)58:3<256::AID-JMV11>3.0.CO;2-Z

Learmont, 1999, Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort, N Engl J Med, 340, 1715, 10.1056/NEJM199906033402203

Lambotte, 2002, Persistence of replication-competent HIV in both memory and naive CD4 T cell subsets in patients on prolonged and effective HAART, AIDS, 16, 2151, 10.1097/00002030-200211080-00007

Crotti, 2006, Nef alleles from human immunodeficiency virus type 1-infected long-term-nonprogressor hemophiliacs with or without late disease progression are defective in enhancing virus replication and CD4 down-regulation, J Virol, 80, 10663, 10.1128/JVI.02621-05

Churchill, 2006, Longitudinal analysis of human immunodeficiency virus type 1 nef/long terminal repeat sequences in a cohort of long-term survivors infected from a single source, J Virol, 80, 1047, 10.1128/JVI.80.2.1047-1052.2006

Lambotte, 2004, The lymphocyte HIV reservoir in patients on long-term HAART is a memory of virus evolution, AIDS, 18, 1147, 10.1097/00002030-200405210-00008