Repeated mild traumatic brain injury induces persistent variations in mitochondrial DNA copy number in mesocorticolimbic neurocircuitry of the rat

Abdul-Muneer, 2015, Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury, Mol. Neurobiol., 51, 966, 10.1007/s12035-014-8752-3 Acerini, 2007, Traumatic brain injury induced hypothalamic-pituitary dysfunction: a paediatric perspective, Pituitary, 10, 373, 10.1007/s11102-007-0052-8 Almeida-Suhett, 2015, GABAergic interneuronal loss and reduced inhibitory synaptic transmission in the hippocampal CA1 region after mild traumatic brain injury, Exp. Neurol., 273, 11, 10.1016/j.expneurol.2015.07.028 André Mendes, 2014, Perspectives on molecular biomarkers of oxidative stress and antioxidant strategies in traumatic brain injury, BioMed Res. Int., 723060 Anglin, 2012, The mitochondrial genome and psychiatric illness, Am. J. Med. Genet. B: Neuropsychiatr. Genet., 159, 749, 10.1002/ajmg.b.32086 Belanger, 2010, Neuropsychological performance following a history of multiple self- reported concussions: a meta-analysis, J. Int. Neuropsychol. Soc., 16, 262, 10.1017/S1355617709991287 Blennow, 2012, The neuropathology and neurobiology of traumatic brain injury, Neuron, 76, 886, 10.1016/j.neuron.2012.11.021 Campbell, 2012, Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number, Biochim. Biophys. Acta, 1819, 921, 10.1016/j.bbagrm.2012.03.002 Chen, 2009, Mitochondrial dynamics-fusion, fission, movement, and mitophagy in neurodegenerative diseases, Hum. Mol. Genet., 18, R169, 10.1093/hmg/ddp326 Chen, 2017, Impact of traumatic brain injury on dopaminergic transmission, Cell Transplant., 26, 1156, 10.1177/0963689717714105 Clay Montier, 2009, Number matters: control of mammalian mitochondrial DNA copy number, J. Genet. Genomics, 36, 125, 10.1016/S1673-8527(08)60099-5 Corral-Frias, 2013, Involvement of the ventral tegmental area in a rodent model of post-traumatic stress disorder, Neuropsychopharmacology, 38, 350, 10.1038/npp.2012.189 Dashnaw, 2012, An overview of the basic science of concussion and subconcussion: where we are and where we are going, Neurosurg. Focus, 33, 10.3171/2012.10.FOCUS12284 Dubinsky, 2009, Heterogeneity of nervous system mitochondria: location, location, location!, Exp. Neurol., 218, 293, 10.1016/j.expneurol.2009.05.020 Dusick, 2012, Pathophysiology of hypopituitarism in the setting of brain injury, Pituitary, 15, 2, 10.1007/s11102-008-0130-6 Fehily, 2017, Repeated mild traumatic brain injury: potential mechanisms of damage, Cell Transplant., 26, 1131, 10.1177/0963689717714092 Felmingham, 2014, Reduced amygdala and ventral striatal activity to happy faces in PTSD is associated with emotional numbing, PLoS One, 9, e103653, 10.1371/journal.pone.0103653 Fischer, 2016, Altered mitochondrial dynamics and TBI pathophysiology, Front. Syst. Neurosci., 10, 29, 10.3389/fnsys.2016.00029 Fuke, 2011, Regional variation in mitochondrial DNA copy number in mouse brain, Biochim. Biophys. Acta, 1807, 270, 10.1016/j.bbabio.2010.11.016 Furda, 2012, Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction, DNA Repair (Amst.), 11, 684, 10.1016/j.dnarep.2012.06.002 Gordon-Weeks, 2000, 260 Harmon, 2017, Striatal mitochondrial disruption following severe traumatic brain injury, J. Neurotrauma, 34, 487, 10.1089/neu.2015.4395 Hiebert, 2015, Traumatic brain injury and mitochondrial dysfunction, Am. J. Med. Sci., 350, 132, 10.1097/MAJ.0000000000000506 Hoffman, 2017, Early and persistent dendritic hypertrophy in the basolateral amygdala following experimental diffuse traumatic brain injury, J. Neurotrauma, 34, 213, 10.1089/neu.2015.4339 Hutson, 2011, Traumatic brain injury in adult rats causes progressive nigrostriatal dopaminergic cell loss and enhanced vulnerability to the pesticide paraquat, J. Neurotrauma, 28, 1783, 10.1089/neu.2010.1723 Javed, 2015, Pituitary and/or hypothalamic dysfunction following moderate to severe traumatic brain injury: current perspectives, Indian J. Endocrinol. Metab., 19, 753, 10.4103/2230-8210.167561 Jin, 2015, Prefrontal-hippocampal interactions in memory and emotion, Front. Syst. Neurosci., 9, 170, 10.3389/fnsys.2015.00170 Katz, 2015, Mild traumatic brain injury, Handb. Clin. Neurol., 127, 131, 10.1016/B978-0-444-52892-6.00009-X Kouneiher, 2009, Motivation and cognitive control in the human prefrontal cortex, Nat. Neurosci., 12, 939, 10.1038/nn.2321 Langlois, 2006, The epidemiology and impact of traumatic brain injury, J. Head Trauma Rehabil., 21, 375, 10.1097/00001199-200609000-00001 Li, 2016, Epidemiology of traumatic brain injury over the world: a systematic review, Gen. Med., 4, e275, 10.4172/2327-5146.1000275 Lifshitz, 2004, Mitochondrial damage and dysfunction in traumatic brain injury, Mitochondrion, 4, 705, 10.1016/j.mito.2004.07.021 Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) method, Methods, 25, 402, 10.1006/meth.2001.1262 Ly, 2006, Mitochondria at the synapse, Neuroscientist, 12, 291, 10.1177/1073858406287661 Lye, 2000, Traumatic brain injury as a risk factor for Alzheimer’s disease: a review, Neuropsychol. Rev., 10, 115, 10.1023/A:1009068804787 Malik, 2016, Accurate quantification of mouse mitochondrial DNA without co-amplification of nuclear mitochondrial insertion sequences, Mitochondrion, 29, 59, 10.1016/j.mito.2016.05.003 Manji, 2012, Impaired mitochondrial function in psychiatric disorders, Nat. Rev. Neurosci., 13, 293, 10.1038/nrn3229 Mattson, 2008, Mitochondria in neuroplasticity and neurological disorders, Neuron, 60, 748, 10.1016/j.neuron.2008.10.010 McKee, 2009, Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury, J. Neuropathol. Exp. Neurol., 68, 709, 10.1097/NEN.0b013e3181a9d503 Morava, 2010, Depressive behaviour in children diagnosed with a mitochondrial disorder, Mitochondrion, 10, 528, 10.1016/j.mito.2010.05.011 Mychasiuk, 2014, A novel model of mild traumatic brain injury for juvenile rats, J. Vis. Exp., 94, e51820 Nagy, 2017, Evaluation of potential reference genes for real-time qPCR analysis in a biparental beetle, Lethrus apterus (Coleoptera: Geotrupidae), PeerJ, 5, e4047, 10.7717/peerj.4047 Nawijn, 2015, Reward functioning in PTSD: a systematic review exploring the mechanisms underlying anhedonia, Neurosci. Biobehav. Rev., 51, 189, 10.1016/j.neubiorev.2015.01.019 Niklas, 2011, Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?, Br. J. Pharmacol., 164, 1207, 10.1111/j.1476-5381.2010.01163.x Ojo, 2014, Neurobehavioral, neuropathological and biochemical profiles in a novel mouse model of co-morbid post-traumatic stress disorder and mild traumatic brain injury, Front. Behav. Neurosci., 8, 213, 10.3389/fnbeh.2014.00213 Oliva, 2016, Ventral tegmental area afferents and drug-dependent behaviors, Front. Psychiatry, 7, 30, 10.3389/fpsyt.2016.00030 Palikaras, 2014, Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis, Exp. Gerontol., 56, 182, 10.1016/j.exger.2014.01.021 Phani, 2010, VTA neurons show a potentially protective transcriptional response to MPTP, Brain Res., 1343, 1, 10.1016/j.brainres.2010.04.061 Picard, 2015, Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress, Proc. Natl. Acad. Sci. U. S. A., 112, E6614, 10.1073/pnas.1515733112 Qian, 2014, Alterations in bioenergetics due to changes in mitochondrial DNA copy number, Methods, 51, 452, 10.1016/j.ymeth.2010.03.006 Ranaldi, 2014, Dopamine and reward seeking: the role of ventral tegmental area, Rev. Neurosci., 25, 621 Rice, 2014, Assessment of cytochrome C oxidase dysfunction in the substantia nigra/ventral tegmental area in schizophrenia, PLoS One, 9, e100054, 10.1371/journal.pone.0100054 Rydbirk, 2016, Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases, Sci. Rep., 6, 37116, 10.1038/srep37116 Sadakierska-Chudy, 2017, The alterations in mitochondrial DNA copy number and nuclear-encoded mitochondrial genes in rat brain structures after cocaine self-administration, Mol. Neurobiol., 54, 7460, 10.1007/s12035-016-0153-3 Sagarkar, 2017, Minimal traumatic brain injury causes persistent changes in DNA methylation at BDNF gene promoters in the amygdala of rat: a possible role in anxiety-like behaviors, Neurobiol. Dis., 106, 101, 10.1016/j.nbd.2017.06.016 Sagarkar, 2019, Repeated mild traumatic brain injury causes persistent changes in histone deacetylase function in hippocampus: implications in learning and memory deficits in rats, Brain Res., 1711, 183, 10.1016/j.brainres.2019.01.022 Schulze, 2017, A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model, BMC Genomics, 18, 975, 10.1186/s12864-017-4356-4 Shapovalov, 2011, Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication, J. Biol. Chem., 286, 22331, 10.1074/jbc.M111.250092 Sheng, 2012, Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease, J. Neurochem., 120, 419, 10.1111/j.1471-4159.2011.07581.x Sheng, 2012, Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration, Nat. Rev. Neurosci., 13, 77, 10.1038/nrn3156 Spielberg, 2008, Prefrontal cortex, emotion, and approach/withdrawal motivation, Soc. Personal. Psychol. Compass, 2, 135, 10.1111/j.1751-9004.2007.00064.x Streck, 2014, Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders, Braz. J. Psychiatr., 36, 156, 10.1590/1516-4446-2013-1224 Tyrka, 2016, Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology, Biol. Psychiatry, 79, 78, 10.1016/j.biopsych.2014.12.025 Vanderploeg, 2012, Health outcomes associated with military deployment: mild traumatic brain injury, blast, trauma, and combat associations in the Florida National Guard, Arch. Phys. Med. Rehabil., 93, 1887, 10.1016/j.apmr.2012.05.024 Vyas, 2002, Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons, J. Neurosci., 22, 6810, 10.1523/JNEUROSCI.22-15-06810.2002 Watson, 2014, Impaired cortical mitochondrial function following TBI precedes behavioral changes, Front. Neuroenerg., 5, 12 Weil, 2014, Injury timing alters metabolic, inflammatory and functional outcomes following repeated mild traumatic brain injury, Neurobiol. Dis., 70, 108, 10.1016/j.nbd.2014.06.016 Wu, 2016, Mitochondrial division inhibitor 1 (Mdivi-1) offers neuroprotection through diminishing cell death and improving functional outcome in a mouse model of traumatic brain injury, Brain Res., 1630, 134, 10.1016/j.brainres.2015.11.016 Xiong, 2013, Animal models of traumatic brain injury, Nat. Rev. Neurosci., 14, 128, 10.1038/nrn3407