Renal function evaluation in patients with American Cutaneous Leishmaniasis after specific treatment with pentavalent antimonial

BMC Nephrology - Tập 13 - Trang 1-6 - 2012
Rodrigo A Oliveira1, Cláudio G Lima1, Rosa Ms Mota2, Alice Mc Martins3, Talita R Sanches4, Antônio C Seguro4,5, Lúcia C Andrade4,5, Geraldo B Silva Junior6,7, Alexandre B Libório7, Elizabeth F Daher6,5
1Department of Internal Medicine, School of Medicine, Federal University of Ceará, Centro, Barbalha, Brazil
2Department of Statistics, Sciences Center, Federal University of Ceará, Fortaleza, Brazil
3School of Pharmacy, Federal University of Ceará, Fortaleza, Brazil
4Division of Nephrology, School of Medicine, University of São Paulo, São Paulo, Brazil
5Brazilian National Research Council (CNPq), São Paulo, Brazil
6Department of Internal Medicine, School of Medicine, Federal University of Ceará, Fortaleza, Brazil
7School of Medicine, Health Sciences Center, University of Fortaleza, Fortaleza, Brazil

Tóm tắt

Renal evaluation studies are rare in American Cutaneous Leishmaniasis (ACL). The aim of this study is to investigate whether specific treatment reverts ACL-associated renal dysfunction. A prospective study was conducted with 37 patients with ACL. Urinary concentrating and acidification ability was assessed before and after treatment with pentavalent antimonial. The patients mean age was 35.6 ± 12 years and 19 were male. Before treatment, urinary concentrating defect (U/Posm <2.8) was identified in 27 patients (77%) and urinary acidification defect in 17 patients (46%). No significant glomerular dysfunction was observed before and after specific ACL treatment. There was no reversion of urinary concentrating defects, being observed in 77% of the patients before and in 88% after treatment (p = 0.344). Urinary acidification defect was corrected in 9 patients after treatment, reducing its prevalence from 40% before to only 16% after treament, (p = 0.012). Microalbuminuria higher than 30 mg/g was found in 35% of patients before treatment and in only 8% after treatment. Regarding fractional excretion of sodium, potassium, calcium, phosphorus and magnesium, there was no significant difference between pre and post-treatment period. As previously described, urinary concentrating and acidification defects were found in an important number of patients with ACL. Present results demonstrate that only some patients recover urinary acidification capacity, while no one returned to normal urinary concentration capacity.

Tài liệu tham khảo

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