Renal effects of dexmedetomidine during coronary artery bypass surgery: a randomized placebo-controlled study

BMC Anesthesiology - Tập 11 Số 1 - 2011
Kari Leino1, Markku Hynynen, J. Jalonen, M Salmenperä, Harry Scheinin, Riku Aantaa
1Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, Turku University Hospital, Turku, Finland. [email protected]

Tóm tắt

Từ khóa


Tài liệu tham khảo

Aantaa R, Jalonen J: Perioperative use of alpha2-adrenoceptor agonists and the cardiac patient. Eur J Anaesthesiol. 2006, 23: 361-372. 10.1017/S0265021506000378.

Aantaa R, Jaakola ML, Kallio A, Kanto J: Reduction of the minimum alveolar concentration of isoflurane by dexmedetomidine. Anesthesiology. 1997, 86: 1055-1060. 10.1097/00000542-199705000-00008.

Jalonen J, Hynynen M, Kuitunen A, Heikkilä H, Perttila J, Salmenpera M, Valtonen M, Aantaa R, Kallio A: Dexmedetomidine as an anesthetic adjunct in coronary artery bypass grafting. Anesthesiology. 1997, 86: 331-345. 10.1097/00000542-199702000-00009.

Lawrence CJ, De Lange S: Effects of a single pre-operative dexmedetomidine dose on isoflurane requirements and peri-operative haemodynamic stability. Anaesthesia. 1997, 52: 736-744. 10.1111/j.1365-2044.1997.169-az0303.x.

Herr DL, Sum-Ping ST, England M: ICU sedation after coronary artery bypass graft surgery: dexmedetomidine-based versus propofol-based sedation regimens. J Cardiothorac Vasc Anesth. 2003, 17: 576-584. 10.1016/S1053-0770(03)00200-3.

Venn M, Newman J, Grounds M: A phase II study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit. Intensive Care Med. 2003, 29: 201-207.

Rosner MH, Portilla D, Okusa MD: Cardiac surgery as a cause of acute kidney injury: pathogenesis and potential therapies. J Intensive Care Med. 2008, 23: 3-18. 10.1177/0885066607309998.

Gellai M, Ruffolo RR: Renal effects of selective alpha-1 and alpha-2 adrenoceptor agonists in conscious, normotensive rats. J Pharmacol Exp Ther. 1987, 240: 723-728.

De Leeuw PW, Birkenhager WH: Alpha-adrenoceptors in the kidney. J Hypertens. 1988, 6 (Suppl): 21-24.

Kulka PJ, Tryba M, Zenz M: Preoperative alpha sub 2-adrenergic receptor agonists prevent the deterioration of renal function after cardiac surgery: Results from a randomized, controlled trial. Crit Care Med. 1996, 24: 947-952. 10.1097/00003246-199606000-00012.

Talke P, Richardson CA, Scheinin M, Fisher DM: Postoperative pharmacokinetics and sympatholytic effects of dexmedetomidine. Anesth Analg. 1997, 85: 1136-1142.

Scheinin M, Koulu M, Laurikainen E, Allonen H: Hypokalemia and other non-bronchial effects of inhaled fenoterol and salbutamol: A placebo-controlled dose-response study in healthy volunteers. Br J Clin Pharmacol. 1987, 24: 645-653.

Ebert TJ, Hall JE, Barney JA, Uhrich TD, Colinco MD: The effects of increasing plasma concentrations of dexmedetomidine in humans. Anesthesiology. 2000, 93: 382-394. 10.1097/00000542-200008000-00016.

Alex J, Shah R, Griffin SC, Cale AR, Cowen ME, Guvendik L: Intensive care unit readmission after elective coronary artery bypass grafting. Asian Cardiovasc Thorac Ann. 2005, 13: 325-329.

Holzmann MJ, Ahnve S, Hammar N, Jorgensen L, Klerdal K, Pehrsson K, Ivert T: Creatinine clearance and risk of early mortality in patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2005, 130: 746-752.

Bove T, Calabro MG, Landoni G, Aletti G, Marino G, Crecsenzi G, Rosica C, Zangrillo A: The incidence and risk of acute renal failure after cardiac surgery. J Cardiothorac Vasc Anesth. 2004, 18: 442-445. 10.1053/j.jvca.2004.05.021.

Loef BG, Epema AH, Smilde TD, Henning RH, Ebels T, Navis G, Stegeman CA: Immediate postoperative renal function deterioration in cardiac surgical patients predicts in-hospital mortality and long-term survival. J Am Soc Nephrol. 2005, 16: 195-200.

Landoni G, Zangrillo A, Franco A, Aletti G, Roberti A, Calabro MG, Slaviero G, Bignami E, Marino G: Long-term outcome of patients who require renal replacement therapy after cardiac surgery. Eur J Anaesthesiol. 2006, 23: 17-22.

Luckraz H, Gravenor MB, George R, Taylir S, Williams A, Ashraf S, Argamo V, Youhana A: Long and short-term outcomes in patients requiring continuous renal replacement therapy post cardiopulmonary bypass. Eur J Cardiothorac Surg. 2005, 27: 906-909. 10.1016/j.ejcts.2005.01.057.

Holzmann MJ, Ahnve S, Hammar N, Jorgensen L, Klerdal K, Pehrsson K, Ivert T: Creatinine clearance and risk of early mortality in patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2005, 130: 746-752.

Sear JW: Kidney dysfunction in the postoperative period. Br J Anaesth. 2005, 95: 20-32. 10.1093/bja/aei018.

Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, ADQI workgroup: Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004, 8: 204-212.

Hammer GB, Drover DR, Cao H, Jackson E, Williams GD, Ramamoorthy C, van Hare GF, Niksch A, Dubin AM: The effects of dexmedetomidine on cardiac electrophysiology in children. Anesth Analg. 2008, 106: 79-83. 10.1213/01.ane.0000297421.92857.4e.

Addis T, Barrett E, Poo LJ, Ureen HJ, Lippman RW: The relation between protein consumption and diurnal variations of the endogenous creatinine clearance in normal individuals. J Clin Invest. 1951, 30: 206-209. 10.1172/JCI102433.

Frumento RJ, Logginidou HG, Wahlander S, Wagener G, Playford HR, Sladen RN: Dexmedtomidine infusion is associated with enhanced renal function after thoracic surgery. J Clin Anaesth. 2006, 18: 422-426. 10.1016/j.jclinane.2006.02.005.

Rouch AJ, Kudo LH, Hebert C: Dexmedetomidine inhibits osmotic water permeability in the rat cortical collecting duct. J Pharmacol Exp Ther. 1997, 281: 62-69.