Renal and brain failure predict mortality of patients with acute-on-chronic liver failure admitted to the intensive care unit

Moreau, 2013, Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis, Gastroenterology, 144, 1426, 10.1053/j.gastro.2013.02.042

Soo, 2019, Describing organ dysfunction in the intensive care unit: a cohort study of 20,000 patients, Crit Care, 23, 186, 10.1186/s13054-019-2459-9

Jalan, 2012, Role of predisposition, injury, response and organ failure in the prognosis of patients with acute-on-chronic liver failure: a prospective cohort study, Crit Care, 16, R227, 10.1186/cc11882

O’Leary, 2018, NACSELD acute-on-chronic liver failure (NACSELD-ACLF) score predicts 30-day survival in hospitalized patients with cirrhosis, Hepatology, 67, 2367, 10.1002/hep.29773

Shawcross, 2011, Infection and systemic inflammation, not ammonia, are associated with grade 3/4 hepatic encephalopathy, but not mortality in cirrhosis, J Hepatol, 54, 640, 10.1016/j.jhep.2010.07.045

Sawhney, 2016, Role of ammonia, inflammation, and cerebral oxygenation in brain dysfunction of acute-on-chronic liver failure patients, Liver Transplant, 22, 732, 10.1002/lt.24443

Bellot, 2010, Bacterial DNA translocation is associated with systemic circulatory abnormalities and intrahepatic endothelial dysfunction in patients with cirrhosis, Hepatology, 52, 2044, 10.1002/hep.23918

da Silva Boteon, 2019, Predictive factors for 28-day mortality in acute-on-chronic liver failure patients admitted to the intensive care unit, Dig Liver Dis, 51, 1416, 10.1016/j.dld.2019.04.008

Bajaj, 2017, Hepatic encephalopathy is associated with mortality in patients with cirrhosis independent of other extrahepatic organ failures, Clin Gastroenterol Hepatol, 15, 565, 10.1016/j.cgh.2016.09.157

Premkumar, 2019, Coagulation failure is associated with bleeding events and clinical outcome during systemic inflammatory response and sepsis in acute-on-chronic liver failure: an observational cohort study, Liver Int, 39, 694, 10.1111/liv.14034

Moreau, 2013, Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis, Gastroenterology, 144, 1426, 10.1053/j.gastro.2013.02.042

Ferrarese, 2019, Outcome of critically ill cirrhotic patients admitted to the ICU: the role of ACLF, J Hepatol, 70, 801, 10.1016/j.jhep.2018.09.015

Gustot, 2015, Clinical course of acute-on-chronic liver failure syndrome and effects on prognosis, Hepatology, 62, 243, 10.1002/hep.27849

Bajaj, 2014, Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures, Hepatology, 60, 250, 10.1002/hep.27077

Singh, 2015, Defining acute-on-chronic liver failure: East, West or Middle ground?, World J Hepatol, 7, 2571, 10.4254/wjh.v7.i25.2571

Papatheodoridis, 2005, MELD vs Child-Pugh and creatinine-modified Child-Pugh score for predicting survival in patients with decompensated cirrhosis, World J Gastroenterol, 11, 3099, 10.3748/wjg.v11.i20.3099

Peng, 2015, Child-Pugh versus MELD score for predicting the in-hospital mortality of acute upper gastrointestinal bleeding in liver cirrhosis, Int J Clin Exp Med, 8, 751

Franco, 2017, Community-acquired pneumonia, Radiol Technol, 88, 621

Velkey, 2017, Spontaneous bacterial peritonitis, Orv Hetil, 158, 50, 10.1556/650.2017.30637

Dubbs, 2019, Evaluation and management of urinary tract infection in the emergency department, Emerg Med Clin North Am, 37, 707, 10.1016/j.emc.2019.07.007

Sokal, 2019, Acute cholangitis: diagnosis and management, J Visc Surg, 156, 515, 10.1016/j.jviscsurg.2019.05.007

Mandell, Douglas and Bennett´s. Principles and Practice of Infectious Diseases. Chapter 75: Sepsis, severe sepsis and septic shock; page: 915-935. 8th edition.

Aldo, 2009, Guías clínicas de diagnóstico y tratamiento de la ascitis Fisiopatología y diagnóstico de la ascitis, Rev Gastroenterol Mex, 74, 387

Atluri, 2011, Pathogenesis, diagnosis, and treatment of hepatic encephalopathy, J Clin Exp Hepatol, 1, 77, 10.1016/S0973-6883(11)60126-6

Ronsoni, 2014, Single-centre validation of the EASL-CLIF consortium definition of acute- on-chronic liver failure and CLIF-SOFA for prediction of mortality in cirrhosis, Liver Int, 1

Dominguez, 2016, Prevalence and risk factors of acute-on-chronic liver failure in a single center from Argentina, World J Hepatol, 8, 1529, 10.4254/wjh.v8.i34.1529

Wu, 2018, Differential characteristics and prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure defined by European Association for the Study of the Liver - Chronic Liver Failure criteria, Hepatol Res, 48, 153, 10.1111/hepr.12909

Hernaez, 2019, Prevalence and short-term mortality of acute-on-chronic liver failure: a national cohort study from the USA, J Hepatol, 70, 639, 10.1016/j.jhep.2018.12.018

Méndez-Sánchez, 2005, Trends in liver disease prevalence in Mexico from 2005 to 2050 through mortality data, Ann Hepatol Off J Mex Assoc Hepatol, 4, 52

Cordoba, 2014, Characteristics, risk factors, and mortality of cirrhotic patients hospitalized for hepatic encephalopathy with and without acute-on-chronic liver failure (ACLF), J Hepatol, 60, 275, 10.1016/j.jhep.2013.10.004