Renal Osteodystrophy—Pathogenesis and Treatment

The American Journal of the Medical Sciences - Tập 290 - Trang 234-245 - 1985
Maj. Howard M. Cushner1
1Departments of Medicine, Divisions of Nephrology, The University of Texas Health Science Center at San Antonio and Brooke Army Medical Center, Fort Sam Houston, Texas

Tài liệu tham khảo

Sherrard, 1982, Calcium and phosphate disorders: Renal osteodystrophy, 57 Rasmussen, 1974, The Physiological and Cellular Basis of Metabolic Bone Disease, 41 Raisz, 1977, Bone metabolism and calcium regulation, 1 Ritz, 1977, Bone histology in renal insufficiency, 197 Rasmussen, 1974, The Physiological and Cellular Basis of Metabolic Bone Disease, 11 Teitelbaum, 1980, Pathological manifestations of osteomalacia and rickets, Clin Endocrinol Metab, 9, 43, 10.1016/S0300-595X(80)80020-X Posner, 1973, Bone mineral on the molecular level, Fed Proc, 32, 1933 Melsen, 1980, Trabecular bone mineralization lag time determined by tetracycline double-labeling in normal and certain pathological conditions, Acta Pathol Microbiol Scand [A], 88, 83 Fallon, 1982, The interpretation of fluorescent tetracycline markers in the diagnosis of metabolic bone diseases, Hum Pathol, 13, 416, 10.1016/S0046-8177(82)80023-3 David, 1977, Mineral and bone homeostasis in renal failure: Pathophysiology and management, 1 Parfitt, 1976, The actions of parathyroid hormone on bone: Relation to bone remodeling and turnover, calcium homeostasis, and metabolic bone diseases, Metabolism, 25, 909, 10.1016/0026-0495(76)90124-4 Neer, 1979, Calcium and inorganic-phosphate homeostasis, 669 Blum, 1974, Acute parathyroid hormone response: Sensitivity, relationship to hypocalcemia, and rapidity, Endocrinology, 95, 753, 10.1210/endo-95-3-753 Coburn, 1980, Renal osteodystrophy, Kidney Int, 17, 677, 10.1038/ki.1980.79 Byers, 1977, The diagnostic value of bone biopsies, 184 Malluche, 1976, Bone histology in incipient and advanced renal failure, Kidney Int, 9, 355, 10.1038/ki.1976.42 Hruska, 1978, The predictability of the histological features of uremic bone disease by non-invasive techniques, Metab Bone Dis Relat Res, 1, 39, 10.1016/0221-8747(78)90035-8 Coburn, 1981, Vitamin D, parathyroid hormone, and renal osteodystrophy, 2213 Holick, 1978, The photo-biogenesis and metabolism of vitamin D, Fed Proc, 37, 2567 Brickman, 1977, Actions of 1 alpha-hydroxyvitamin D3 and 1,25-di-hydroxyvitamin D3 on mineral metabolism in man, Am J Clin Nutr, 30, 1064, 10.1093/ajcn/30.7.1064 Holtrop, 1981, 1,25-dihydroxy-cholecalciferol stimulates osteoclasts in rat bones in the absence of parathyroid hormone, Endocrinology, 108, 2293, 10.1210/endo-108-6-2293 Maierhofer, 1983, Bone resorption stimulated by elevated serum l,25-(OH)2D-vitamin D concentrations in healthy man, Kidney Int, 24, 555, 10.1038/ki.1983.193 Slatopolsky, 1979, The pathogenesis of secondary hyperparathyroidism in early renal failure, 1209 Juttmann, 1981, Serum concentrations of metabolites of vitamin D in patients with chronic renal failure. Consequences for the treatment with alpha-hydroxy-derivatives, Clin Endocrinol, 14, 225, 10.1111/j.1365-2265.1981.tb00191.x Offermann, 1974, Serum 25-hydroxycholecalciferol in uremia, Nephron, 13, 269, 10.1159/000180403 Pierides, 1976, Barbiturate and anticonvulsant treatment in relation to osteomalacia with hemodialysis and renal transplantation, Br Med J, 1, 190, 10.1136/bmj.1.6003.190 Stern, 1980, Evidence for abnormal regulation of circulating l-alpha-25-dihydroxyvitamin D in patients with sarcoidosis and normal calcium metabolism, J Clin Invest, 66, 852, 10.1172/JCI109924 Haussler, 1975, 1 alpha, 25-dihydroxyvitamin D3 in idiopathic hypoparathyroidism: Assay of circulating concentration and therapeutic effect of the sterol, Clinical Research, 23, 155A Reiss, 1968, Experience with a radioimmunoassay of parathyroid hormone in human sera, Trans Assoc Am Physicians, 81, 104 Bikle, 1975, The ionic control of 1,25-dihydroxyvitamin D3 synthesis of isolated chick renal mitochondria. The role of calcium as influenced by inorganic phosphate and hydrogen ion, J Clin Invest, 55, 299, 10.1172/JCI107933 Portale, 1982, Reduced plasma concentration of 1,25-dihydroxyvitamin D in children with moderate renal insufficiency, Kidney Int, 21, 627, 10.1038/ki.1982.70 Portale, 1982, Effect of dietary phosphorus on plasma 1,25-(OH)2D in children with moderate renal insufficiency, Kidney Int, 21, 139, 10.1038/ki.1982.70 Kawashima, 1981, Localization of 25-hydroxy-vitamin D3 1 alpha-hydroxylase and 24-hydroxylase along the rat nephron, Proc Natl Acad Sci USA, 78, 1199, 10.1073/pnas.78.2.1199 Brewer, 1977, Maleic acid-induced impaired conversion of 25(OH)D3 to 1,25-(OH)2D3: Implications for Fanconi’s syndrome, Kidney Int, 12, 244, 10.1038/ki.1977.109 Chesney, 1982, Circulating vitamin D metabolite concentrations in childhood renal diseases, Kidney Int, 21, 65, 10.1038/ki.1982.9 Coburn, 1969, The physicochemical state and renal handling of divalent ions in chronic renal failure, Arch Intern Med, 124, 302, 10.1001/archinte.1969.00300190042007 Stanbury, 1962, Metabolic studies of renal osteodystrophy. I. Calcium, phosphorus, and nitrogen metabolism in rickets, osteomalacia, and hyperparathyroidism complicating chronic uremia and the osteomalacia of the adult Fanconi syndrome, Medicine, 41, 1, 10.1097/00005792-196202000-00001 Llach, 1975, Skeletal resistance to endogenous parathyroid hormone in patients with early renal failure. A possible cause for secondary hyperparathyroidism, J Clin Endocrinol Metab, 41, 339, 10.1210/jcem-41-2-339 Garabedian, 1976, Response of intestinal calcium transport and bone calcium mobilization to 1,25-dihydroxyvitamin D3 in thyroparathyroidectomized rats, Endocrinology, 94, 1022, 10.1210/endo-94-4-1022 Reiss, 1970, The role of phosphate in the secretion of parathyroid hormone in man, J Clin Invest, 49, 2146, 10.1172/JCI106432 Goldsmith, 1975, Effects of calcium and phosphorus on patients maintained on dialysis, Kidney Int, 7, S118 Parker, 1980, Magnesium and calcium mass transfer during continuous ambulatory peritoneal dialysis, Trans Am Soc Artif Intern Organs, 26, 194 Arnaud, 1973, Hyperparathyroidism and renal failure, Kidney Int, 4, 89, 10.1038/ki.1973.87 Slatopolsky, 1971, On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog, J Clin Invest, 50, 492, 10.1172/JCI106517 Bricker, 1972, On the pathogenesis of the uremic state. An exposition of the “trade-off hypothesis.”, N Engl J Med, 286, 1093, 10.1056/NEJM197205182862009 Slatopolsky, 1973, The role of phosphorus restriction in the prevention of secondary hyperparathyroidism in chronic renal disease, Kidney Int, 4, 141, 10.1038/ki.1973.92 Llach, 1977, Secondary hyperparathyroidism in early renal failure: Role of phosphate retention, Kidney Int, 12, 459 Slatopolsky, 1983, Marked suppression of secondary hyperparathyroidism by intravenous 1,25-(OH)2D3 in uremic patients, Kidney Int, 23, 162 Rutherford, 1977, Phosphate control and 25-hydroxy-cholecalciferol administration in preventing experimental renal osteodystrophy in the dog, J Clin Invest, 60, 332, 10.1172/JCI108781 Bordier, 1973, Fournier A, deWardener HE: Lack of histological evidence of vitamin D abnormality in the bones of anephric patients, Clin Sci, 44, 33, 10.1042/cs0440033 Kanis, 1977, Vitamin D, osteomalacia and chronic renal failure, 671 Albright, 1948, 116 Lemann, 1972, Role of diet, gastrointestinal tract and bone in acid-base homeostasis, Kidney Int, 1, 275, 10.1038/ki.1972.40 Litzow, 1967, The effect of treatment of acidosis on calcium balance in patients with chronic azotemic renal disease, J Clin Invest, 46, 280, 10.1172/JCI105530 Griffith, 1965, Heparin osteoporosis, JAMA, 193, 91, 10.1001/jama.1965.03090020005001 Jaffe, 1965, Multiple fractures associated with long-term sodium heparin therapy, JAMA, 193, 158, 10.1001/jama.1965.03090020072024 Baker, 1974, Iatrogenic osteomalacia and myopathy due to phosphate depletion, Br Med J, 3, 150, 10.1136/bmj.3.5924.150 Abrams, 1974, Antacid induction of phosphate depletion syndrome in renal failure, West J Med, 120, 157 Mahony, 1976, Hypophosphatémie osteomalacia in patients receiving hemodialysis, Br Med J, 2, 142, 10.1136/bmj.2.6028.142 Platts, 1977, Composition of the domestic water supply and the incidence of fractures and encelopathy in patients on home dialysis, Br Med J, 2, 657, 10.1136/bmj.2.6088.657 Kaehny, 1977, Aluminum transfer during hemodialysis, Kidney Int, 12, 361, 10.1038/ki.1977.123 Pierides, 1980, Hemodialysis encephalopathy with osteomalacic fractures and muscle weakness, Kidney Int, 18, 10.1038/ki.1980.117 Ward, 1978, Osteomalacic dialysis osteodystrophy: Evidence for a water-borne aetiological agent, probably aluminum, Lancet, 1, 841, 10.1016/S0140-6736(78)90191-5 Parkinson, 1979, Fracturing dialysis osteodystrophy and dialysis encephalopathy. An epidemiological survey, Lancet, 1, 406, 10.1016/S0140-6736(79)90883-3 Comty, 1978, Pretreatment and preparation of city water for hemodialysis, 155 Ott, 1982, The prevalence of bone aluminum deposition in renal osteodystrophy and its relation to the response to calcitriol therapy, N Engl J Med, 307, 709, 10.1056/NEJM198209163071202 Cournot-Witmer, 1981, Aluminum localization in bone from hemodialyzed patients: Relationship to bone matrix mineralization, Kidney Int, 20, 375, 10.1038/ki.1981.149 Ellis, 1979, Bone aluminum in hemodialyzed patients and in rats injected with aluminum chloride: Relationship to impaired bone mineralization, J Clin Pathol, 32, 832, 10.1136/jcp.32.8.832 Robertson, 1983, Animal model of aluminum-induced osteomalacia: Role of chronic renal failure, Kidney Int, 23, 327, 10.1038/ki.1983.23 Goodman, 1982 Ott, 1983, Aluminum is associated with low bone formation in patients receiving chronic parenteral nutrition, Ann Intern Med, 98, 910, 10.7326/0003-4819-98-6-910 Hodsman, 1981, Vitamin-D-resistant osteomalacia in hemodialysis patients lacking secondary hyperparathyroidism, Ann Intern Med, 94, 629, 10.7326/0003-4819-94-5-629 Boyce, 1982, Hypercalcemic osteomalacia due to aluminum toxicity, Lancet, 2, 1009, 10.1016/S0140-6736(82)90049-6 Sherrard, 1982, The use of 24,25(OH)2D in the refractory osteomalacia form of renal osteodystrophy, 169 Rodan, 1981, Role of osteoblasts in hormonal control of bone resorption—A hypothesis, Caleif Tissue Int, 33, 349, 10.1007/BF02409454 Felsenfeld, 1982, Osteomalacia after parathyroidectomy in patients with uremia, Ann Intern Med, 96, 34, 10.7326/0003-4819-96-1-34 Teitelbaum, 1980, Do parathyroid hormone and 1,25-dihydroxyvitamin D modulate bone formation in uremia?, J Clin Endocrinol Metab, 51, 247, 10.1210/jcem-51-2-247 Hodsman, 1982, Bone aluminum and histomorphometric features of renal osteodystrophy, J Clin Endocrinol Metab, 54, 539, 10.1210/jcem-54-3-539 Morrissey, 1982, Suppression of parathyroid hormone release by aluminum, Kidney Int, 21, 138 Healy, 1980, Effects of long-term therapy with calcitriol in patients with moderate renal failure, Arch Intern Med, 140, 1030, 10.1001/archinte.1980.00330190042017 Chan, 1981, Effects of 1,25-dihydroxyvitamin-D3 on renal function, mineral balance, and growth in children with severe chronic renal failure, Pediatrics, 68, 559, 10.1542/peds.68.4.559 Teitelbaum, 1981, Calcifediol (25-hydroxyvitamin D3) in the treatment of uremic bone disease, Ann Intern Med, 94, 404, 10.7326/0003-4819-94-3-404 Christiansen, 1978, Deterioration of renal function during treatment of chronic renal failure with 1,25-dihydroxycholecalciferol, Lancet, 2, 700, 10.1016/S0140-6736(78)92702-2 Tougaard, 1976, Controlled trial of 1 alpha-hydroxycholecalciferol in chronic renal failure, Lancet, 1, 1044, 10.1016/S0140-6736(76)92220-0 Massry, 1979, Is calcitriol harmful to renal function?, JAMA, 242, 1875, 10.1001/jama.242.17.1875 Curtis, 1970, deWardener H, Gower P, Eastwood JB: The use of calcium carbonate and calcium phosphate without vitamin D in the management of renal osteodystrophy, Proc Eur Dial Transplant Assoc, 7, 141 Meyrier, 1973, The influence of a high calcium carbonate intake on bone disease in patients undergoing hemodialysis, Kidney Int, 4, 146, 10.1038/ki.1973.93 Sherrard, 1980, Skeletal response to treatment with 1,25-dihydroxy-vitamin D in renal failure, Contrib Nephrol, 18, 92, 10.1159/000403276 Kaehny, 1977, Gastrointestinal absorption of aluminum from aluminum-containing antacids, N Engl J Med, 296, 1389, 10.1056/NEJM197706162962407 Moriniere, 1983, Substitution of aluminum hydroxide by high doses of calcium carbonate in patients on chronic hemodialysis: Disappearance of hyperaluminemia and equal control of hyperparathyroidism, Proc Eur Dial Transplant Assoc, 19, 784 Markoff, 1969, Calcium carbonate therapy in uremia, Arch Intern Med, 123, 15, 10.1001/archinte.1969.00300110017003 Hodsman, 1983, Preliminary trials with 24,25-dihydroxyvitamin D3 in dialysis osteomalacia, Am J Med, 74, 407, 10.1016/0002-9343(83)90959-2 Ott, 1983, Vitamin D therapy in aluminum-related osteomalacia, Kidney Int, 23, 107 Milliner, 1984, Use of deferoxamine infusion test in diagnosis of aluminum-related osteodystrophy, Ann Intern Med, 101, 775, 10.7326/0003-4819-101-6-775 Malluche, 1984, The use of deferoxamine in the management of aluminum accumulation in bone in patients with renal failure, N Engl J Med, 311, 140, 10.1056/NEJM198407193110302 Nebeker, 1984 Gokal, 1983, Histological renal osteodystrophy, and 25-hydroxycholecalciferol and aluminum levels in patients on continuous ambulatory peritoneal dialysis, Kidney Int, 23, 15, 10.1038/ki.1983.4 Gokal, 1981, Improvement in secondary hyperparathyroidism in patients on continuous ambulatory peritoneal dialysis, 461 Delmez, 1982, Minerals, vitamin D, and parathyroid hormone in continuous ambulatory peritoneal dialysis, Kidney Int, 21, 862, 10.1038/ki.1982.110