Remote Ischemic Preconditioning: A Novel Protective Method From Ischemia Reperfusion Injury—A Review

Journal of Surgical Research - Tập 150 Số 2 - Trang 304-330 - 2008
Niteen Tapuria1, Yogesh Kumar1, M.M. Habib1, Mahmoud Abu Amara1, Alexander M. Seifalian1, Brian R Davidson1
1Institute-Hepatobiliary Pancreatic and Liver Transplant Unit, University Department of Surgery, Royal Free and University College School of Medicine, UCL, London, United Kingdom.

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Jaeschke, 2002, Kupffer cell activation after no-flow ischemia versus hemorrhagic shock, Free Radic Biol Med, 33, 210, 10.1016/S0891-5849(02)00867-5

Eckert, 1991, Ischemic tolerance of human skeletal muscle, Ann Plast Surg, 26, 77, 10.1097/00000637-199101000-00012

Tountas, 1977, Tourniquet ischemia: Ultrastructural and histochemical observations of ischemic human muscle and of monkey muscle and nerve, J Hand Surg [Am], 2, 31, 10.1016/S0363-5023(77)80007-5

Larsson, 1979, The effect of long-term arterial occlusion on energy metabolism of the human quadriceps muscle, Scand J Clin Lab Invest, 39, 257, 10.3109/00365517909106103

Carden, 2000, Pathophysiology of ischaemia-reperfusion injury, J Pathol, 190, 255, 10.1002/(SICI)1096-9896(200002)190:3<255::AID-PATH526>3.0.CO;2-6

Clavien, 1992, Preservation and reperfusion injuries in liver allografts, Transplantation, 53, 957, 10.1097/00007890-199205000-00001

Margarit, 2000, Analysis of risk factors following pediatric liver transplantation, Transpl Int, 13, S150, 10.1111/j.1432-2277.2000.tb02008.x

Pokorny, 2000, Organ survival after primary dysfunction of liver grafts in clinical orthotopic liver transplantation, Transpl Int, 13, S154, 10.1007/s001470050310

Yamakawa, 2000, Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation, Ann Surg, 231, 387, 10.1097/00000658-200003000-00012

Perdrizet, 2006, Major hepatic trauma: Warm ischemic tolerance of the liver after hemorrhagic shock, J Surg Res, 136, 70, 10.1016/j.jss.2006.06.032

Liu, 1996, Multiple-system organ damage resulting from prolonged hepatic inflow interruption, Arch Surg, 131, 442, 10.1001/archsurg.1996.01430160100022

Fellstrom, 1998, Postischemic reperfusion injury and allograft arteriosclerosis, Transplant Proc, 30, 4278, 10.1016/S0041-1345(98)01412-2

Murry, 1986, Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium, Circulation, 74, 1124, 10.1161/01.CIR.74.5.1124

Peralta, 1996, Liver ischemic preconditioning is mediated by the inhibitory action of nitric oxide on endothelin, Biochem Biophys Res Commun, 229, 264, 10.1006/bbrc.1996.1790

Yin, 1998, Protective effect of ischemic preconditioning on liver preservation-reperfusion injury in rats, Transplantation, 66, 152, 10.1097/00007890-199807270-00002

Arai, 1999, Protection of sinusoidal endothelial cells against storage/reperfusion injury by prostaglandin E2 derived from Kupffer cells, Transplantation, 68, 440, 10.1097/00007890-199908150-00017

Peralta, 2001, Preconditioning protects against systemic disorders associated with hepatic ischemia-reperfusion through blockade of tumor necrosis factor-induced P-selectin up-regulation in the rat, Hepatology, 33, 100, 10.1053/jhep.2001.20529

Fernandez, 2002, Preconditioning protects liver and lung damage in rat liver transplantation: role of xanthine/xanthine oxidase, Hepatology, 36, 562, 10.1053/jhep.2002.34616

McClanahan, 1993, Brief renal occlusion and reperfusion reduces myocardial infarct size in rabbits, FASEB J, 7

Kharbanda, 2002, Transient limb ischemia induces remote ischemic preconditioning in vivo, Circulation, 106, 2881, 10.1161/01.CIR.0000043806.51912.9B

Przyklenk, 1993, Regional ischemic ‘preconditioning’ protects remote virgin myocardium from subsequent sustained coronary occlusion, Circulation, 87, 893, 10.1161/01.CIR.87.3.893

Nakano, 2002, Preconditioning one myocardial region does not neccessarily precondition the whole rabbit heart, Basic Res Cardiol, 97, 35, 10.1007/s395-002-8385-3

Tokuno, 2002, Spontaneous ischemic events in the brain and heart adapt the hearts of severely atherosclerotic mice to ischemia, Arterioscler Thromb Vasc Biol, 22, 995, 10.1161/01.ATV.0000017703.87741.12

Ates, 2002, Renal protection by brief liver ischemia in rats, Transplantation, 74, 1247, 10.1097/00007890-200211150-00009

Takaoka, 1999, Renal ischemia/reperfusion remotely improves myocardial energy metabolism during myocardial ischemia via adenosine receptors in rabbits: Effects of “remote preconditioning”, J Am Coll Cardiol, 33, 556, 10.1016/S0735-1097(98)00559-2

Gho, 1996, Myocardial protection by brief ischemia in noncardiac tissue, Circulation, 94, 2193, 10.1161/01.CIR.94.9.2193

Pell, 1998, Renal ischemia preconditions myocardium: Role of adenosine receptors and ATP-sensitive potassium channels, Am J Physiol Heart Circ Physiol, 275, H1542, 10.1152/ajpheart.1998.275.5.H1542

Singh, 2004, Evidence of the role of angiotensin AT(1) receptors in remote renal preconditioning of myocardium, Methods Find Exp Clin Pharmacol, 26, 117, 10.1358/mf.2004.26.2.800064

Schoemaker, 2000, Bradykinin mediates cardiac preconditioning at a distance, Am J Physiol Heart Circ Physiol, 278, H1571, 10.1152/ajpheart.2000.278.5.H1571

Wolfrum, 2002, Remote preconditioning protects the heart by activating myocardial PKCepsilon-isoform, Cardiovasc Res, 55, 583, 10.1016/S0008-6363(02)00408-X

Wolfrum, 2005, Calcitonin gene related peptide mediates cardioprotection by remote preconditioning, Regul Pept, 127, 217, 10.1016/j.regpep.2004.12.008

Liem, 2002, Sites of action of adenosine in interorgan preconditioning of the heart, Am J Physiol Heart Circ Physiol, 283, H29, 10.1152/ajpheart.01031.2001

Patel, 2002, Cardioprotection at a distance: Mesenteric artery occlusion protects the myocardium via an opioid sensitive mechanism, J Mol Cell Cardiol, 34, 1317, 10.1006/jmcc.2002.2072

Xiao, 2001, Delayed cardioprotection by intestinal preconditioning is mediated by calcitonin gene-related peptide, Eur J Pharmacol, 427, 131, 10.1016/S0014-2999(01)01231-6

Tang, 1999, Involvement of capsaicin-sensitive sensory nerves in early and delayed cardioprotection induced by a brief ischaemia of the small intestine, Naunyn Schmiedebergs Arch Pharmacol, 359, 243, 10.1007/PL00005348

Wang, 2001, Intestinal ischemia induces late preconditioning against myocardial infarction: A role for inducible nitric oxide synthase, Cardiovasc Res, 49, 391, 10.1016/S0008-6363(00)00266-2

Vlasov, 2001, [Adaptation of the rat small intestine to ischemia], Ross. Fiziol. Zh. Im I. M. Sechenova, 87, 118

Oxman, 1997, Limb ischemia preconditions the heart against reperfusion tachyarrhythmia, Am J Physiol, 273, H1707

Birnbaum, 1997, Ischemic preconditioning at a distance: Reduction of myocardial infarct size by partial reduction of blood supply combined with rapid stimulation of the gastrocnemius muscle in the rabbit, Circulation, 96, 1641, 10.1161/01.CIR.96.5.1641

Konstantinov, 2005, The remote ischemic preconditioning stimulus modifies gene expression in mouse myocardium, J Thorac Cardiovasc Surg, 130, 1326, 10.1016/j.jtcvs.2005.03.050

Weinbrenner, 2004, Remote preconditioning by infrarenal aortic occlusion is operative via delta1-opioid receptors and free radicals in vivo in the rat heart, Cardiovasc Res, 61, 591, 10.1016/j.cardiores.2003.10.008

Gunaydin, 2000, Does remote organ ischaemia trigger cardiac preconditioning during coronary artery surgery?, Res, 41, 493

Petrishchev, 2001, Does nitric oxide generation contribute to the mechanism of remote ischemic preconditioning?, Pathophysiology, 7, 271, 10.1016/S0928-4680(00)00058-4

Li, 2004, Myocardial protection by remote preconditioning: The role of nuclear factor kappa-B p105 and inducible nitric oxide synthase, Eur J Cardiothorac Surg, 26, 968, 10.1016/j.ejcts.2004.06.015

Kristiansen, 2005, Remote preconditioning reduces ischemia-reperfusion injury in the explanted heart by a KATP channel-dependent mechanism, Am J Physiol Heart Circ Physiol, 288, H1252, 10.1152/ajpheart.00207.2004

Konstantinov, 2005, Remote ischemic preconditioning of the recipient reduces myocardial ischemia-reperfusion injury of the denervated donor heart via a Katp channel-dependent mechanism, Transplantation, 79, 1691, 10.1097/01.TP.0000159137.76400.5D

Moses, 2005, Mitochondrial KATP channels in hind limb remote ischemic preconditioning of skeletal muscle against infarction, Am J Physiol Heart Circ Physiol, 288, H559, 10.1152/ajpheart.00845.2004

Kuntscher, 2003, Late remote ischemic preconditioning in rat muscle and adipocutaneous flap models, Ann Plast Surg, 51, 84, 10.1097/01.SAP.0000054186.10681.E2

Addison, 2003, Noninvasive remote ischemic preconditioning for global protection of skeletal muscle against infarction, Am J Physiol Heart Circ Physiol, 285, H1435, 10.1152/ajpheart.00106.2003

Kuntscher, 2003, Role of nitric oxide in the mechanism of preclamping and remote ischemic preconditioning of adipocutaneous flaps in a rat model, J Reconstr Microsurg, 19, 55, 10.1055/s-2003-37192

Kuntscher, 2002, Acute remote ischemic preconditioning II: The role of nitric oxide, Microsurgery, 22, 227, 10.1002/micr.10042

Kuntscher, 2002, Acute remote ischemic preconditioning on a rat cremasteric muscle flap model, Microsurgery, 22, 221, 10.1002/micr.10041

Kuntscher, 2002, Ischemic preconditioning by brief extremity ischemia before flap ischemia in a rat model, Plast Reconstr Surg, 109, 2398, 10.1097/00006534-200206000-00034

Liauw, 1996, Sequential ischemia/reperfusion results in contralateral skeletal muscle salvage, Am J Physiol Heart Circ Physiol, 270, H1407, 10.1152/ajpheart.1996.270.4.H1407

Wang, 2004, Ischemic preconditioning-induced microvascular protection at a distance, J Reconstr Microsurg, 20, 175, 10.1055/s-2004-820775

Vlasov, 2004, [Ischemic adaptation of the rat brain as a method for protection of endothelium from ischemic reperfusion injury], Ross Fiziol Zh Im I M Sechenova, 90, 40

Xia, 2003, Remote preconditioning lessens the deterioration of pulmonary function after repeated coronary artery occlusion and reperfusion in sheep, Can J Anaesth, 50, 481, 10.1007/BF03021061

Harkin, 2002, Ischemic preconditioning before lower limb ischemia–reperfusion protects against acute lung injury, J Vasc Surg, 35, 1264, 10.1067/mva.2002.121981

Waldow, 2005, Protection against acute porcine lung ischemia/reperfusion injury by systemic preconditioning via hind limb ischemia, Transpl Int, 18, 198, 10.1111/j.1432-2277.2004.00005.x

Brzozowski, 2004, Ischemic preconditioning of remote organs attenuates gastric ischemia-reperfusion injury through involvement of prostaglandins and sensory nerves, Eur J Pharmacol, 499, 201, 10.1016/j.ejphar.2004.07.072

Brzozowski, 2004, Importance of brain-gut axis in the gastroprotection induced by gastric and remote preconditioning, J Physiol Pharmacol, 55, 165

Liem, 2005, Myocardium tolerant to an adenosine-dependent ischemic preconditioning stimulus can still be protected by stimuli that employ alternative signaling pathways, Am J Physiol Heart Circ Physiol, 288, H1252, 10.1152/ajpheart.00899.2004

Ren, 2004, TNF-alpha is required for late ischemic preconditioning but not for remote preconditioning of trauma, J Surg Res, 121, 120, 10.1016/j.jss.2004.03.010

Minatoguchi, 2003, Cross-talk among noradrenaline, adenosine and protein kinase C in the mechanisms of ischemic preconditioning in rabbits, J Cardiovasc Pharmacol, 41, S39

Costa, 2001, NO modulates norepinephrine release in human skeletal muscle: Implications for neural preconditioning, Am J Physiol Regul Integr Comp Physiol, 280, R1494, 10.1152/ajpregu.2001.280.5.R1494

Dickson, 2002, Myocardial preconditioning factors evoke mesenteric ischemic tolerance via opioid receptors and K(ATP) channels, Am J Physiol Heart Circ Physiol, 283, H22, 10.1152/ajpheart.01055.2001

Dickson, 1999, Rabbit heart can be “preconditioned” via transfer of coronary effluent, Am J Physiol, 277, H2451

Dickson, 2001, Naloxone blocks transferred preconditioning in isolated rabbit hearts, J Mol Cell Cardiol, 33, 1751, 10.1006/jmcc.2001.1436

Dickson, 1999, Ischemic preconditioning may be transferable via whole blood transfusion: Preliminary evidence, J Thromb Thrombolysis, 8, 123, 10.1023/A:1008911101951

Bolli, 2000, The late phase of preconditioning, Circ Res, 87, 972, 10.1161/01.RES.87.11.972

Kuzuya, 1993, Delayed effects of sublethal ischemia on the acquisition of tolerance to ischemia, Circ Res, 72, 1293, 10.1161/01.RES.72.6.1293

Yamashita, 1998, A “second window of protection” occurs 24 h after ischemic preconditioning in the rat heart, J Mol Cell Cardiol, 30, 1181, 10.1006/jmcc.1998.0682

Cheung, 2006, Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: First clinical application in humans, J Am Coll Cardiol, 47, 2277, 10.1016/j.jacc.2006.01.066

Loukogeorgakis, 2005, Remote ischemic preconditioning provides early and late protection against endothelial ischemia-reperfusion injury in humans: role of the autonomic nervous system, J Am Coll Cardiol, 46, 450, 10.1016/j.jacc.2005.04.044

Chen, 2005, [Mechanism of the protective effects of noninvasive limbs preconditioning on myocardial ischemia-reperfusion injury.], Chin Med J (Engl), 118, 1723

Chen, 2005, Protection “outside the box” (skeletal remote preconditioning) in rat model is triggered by free radical pathway, J Surg Res, 126, 92, 10.1016/j.jss.2005.01.007

Kanoria, 2006, Remote ischaemic preconditioning of the hind limb reduces experimental liver warm ischaemia-reperfusion injury, Br J Surg, 93, 762, 10.1002/bjs.5331

Weinbrenner, 2002, Remote preconditioning by infrarenal occlusion of the aorta protects the heart from infarction: A newly identified non-neuronal but PKC-dependent pathway, Cardiovasc Res, 55, 590, 10.1016/S0008-6363(02)00446-7

Langle, 1995, Arginase release following liver reperfusion, Transplantation, 59, 1542, 10.1097/00007890-199506000-00007

Peralta, 2001, Endogenous nitric oxide and exogenous nitric oxide supplementation in hepatic ischemia-reperfusion injury in the rat, Transplantation, 71, 529, 10.1097/00007890-200102270-00008

Bauer, 1997, Role of nitric oxide in the regulation of the hepatic microcirculation in vivo, J Hepatol, 27, 1089, 10.1016/S0168-8278(97)80153-5

Albrecht, 2003, Protective role of endothelial nitric oxide synthase, J Pathol, 199, 8, 10.1002/path.1250

Kubes, 2000, Nitric oxide and intestinal inflammation, Am J Med, 109, 150, 10.1016/S0002-9343(00)00480-0

Wink, 1993, Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species, Proc Natl Acad Sci USA, 90, 9813, 10.1073/pnas.90.21.9813

Kosonen, 2000, Inhibition by nitric oxide-releasing compounds of E-selectin expression in and neutrophil adhesion to human endothelial cells, Eur J Pharmacol, 394, 149, 10.1016/S0014-2999(00)00141-2

Kosonen, 1999, Nitric oxide-releasing compounds inhibit neutrophil adhesion to endothelial cells, Eur J Pharmacol, 382, 111, 10.1016/S0014-2999(99)00581-6

Kosonen, 1998, Inhibition by nitric oxide-releasing compounds of prostacyclin production in human endothelial cells, Br J Pharmacol, 125, 247, 10.1038/sj.bjp.0702042

Lefer, 1996, The role of nitric oxide and cell adhesion molecules on the microcirculation in ischaemia-reperfusion, Cardiovasc Res, 32, 743, 10.1016/0008-6363(96)00073-9

Wink, 1998, Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide, Free Radic Biol Med, 25, 434, 10.1016/S0891-5849(98)00092-6

Gauthier, 1994, Nitric oxide attenuates leukocyte-endothelial interaction via P-selectin in splanchnic ischemia-reperfusion, Am J Physiol, 267, G562

Horton, 1993, Free radical scavengers prevent intestinal ischemia-reperfusion-mediated cardiac dysfunction, J Surg Res, 55, 282, 10.1006/jsre.1993.1141

Downey, 1997, Signal transduction in ischemic preconditioning, Adv Exp Med Biol, 430, 39, 10.1007/978-1-4615-5959-7_4

Kelly, 1996, Nitric oxide and cardiac function, Circ Res, 79, 363, 10.1161/01.RES.79.3.363

Peralta, 1999, The protective role of adenosine in inducing nitric oxide synthesis in rat liver ischemia preconditioning is mediated by activation of adenosine A2 receptors, Hepatology, 29, 126, 10.1002/hep.510290104

Jaeschke, 1996, Mechanisms of inflammatory liver injury: Adhesion molecules and cytotoxicity of neutrophils, Toxicol Appl Pharmacol, 139, 213, 10.1006/taap.1996.0160

Rockey, 1995, Inducible nitric oxide synthase in rat hepatic lipocytes and the effect of nitric oxide on lipocyte contractility, J Clin Invest, 95, 1199, 10.1172/JCI117769

Harbrecht, 1997, Inhibition of nitric oxide synthesis during severe shock but not after resuscitation increases hepatic injury and neutrophil accumulation in hemorrhaged rats, Shock, 8, 415, 10.1097/00024382-199712000-00004

Lochner, 2002, Nitric oxide triggers classic ischemic preconditioning, Ann NY Acad Sci, 962, 402, 10.1111/j.1749-6632.2002.tb04084.x

Gidday, 1999, Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning, J Cereb Blood Flow Metab, 19, 331, 10.1097/00004647-199903000-00011

Nandagopal, 2001, Critical role for nitric oxide signaling in cardiac and neuronal ischemic preconditioning and tolerance, J Pharmacol Exp Ther, 297, 474

Kim, 2000, Nitric oxide prevents tumor necrosis factor alpha-induced rat hepatocyte apoptosis by the interruption of mitochondrial apoptotic signaling through S-nitrosylation of caspase-8, Hepatology, 32, 770, 10.1053/jhep.2000.18291

Kim, 1998, Nitric oxide suppression of apoptosis occurs in association with an inhibition of Bcl-2 cleavage and cytochrome c release, J Biol Chem, 273, 31437, 10.1074/jbc.273.47.31437

Kim, 1998, Nitric oxide prevents IL-1beta and IFN-gamma-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1beta-converting enzyme), J Immunol, 161, 4122, 10.4049/jimmunol.161.8.4122

Guo, 1996, Direct measurement of nitric oxide release from vascular endothelial cells, J Appl Physiol, 81, 774, 10.1152/jappl.1996.81.2.774

Suzuki, 2000, Inducible nitric oxide synthase gene knockout mice have increased resistance to gut injury and bacterial translocation after an intestinal ischemia-reperfusion injury, Crit Care Med, 28, 3692, 10.1097/00003246-200011000-00026

Wu, 2002, iNOS enhances rat intestinal apoptosis after ischemia-reperfusion, Free Radic Biol Med, 33, 649, 10.1016/S0891-5849(02)00917-6

Cuzzocrea, 1998, Role of constitutive nitric oxide synthase and peroxynitrite production in a rat model of splanchnic artery occlusion shock, Life Sci, 63, 789, 10.1016/S0024-3205(98)00334-8

Downey, 1993, Adenosine and the anti-infarct effects of preconditioning, Cardiovasc Res, 27, 3, 10.1093/cvr/27.1.3

Pang, 1997, Effector mechanism of adenosine in acute ischemic preconditioning of skeletal muscle against infarction, Am J Physiol, 273, R887

Horie, 2001, Liver dysfunction elicited by gut ischemia-reperfusion, Pathophysiology, 8, 11, 10.1016/S0928-4680(01)00063-3

Dana, 2000, Adenosine A(1) receptor induced delayed preconditioning in rabbits: Induction of p38 mitogen-activated protein kinase activation and Hsp27 phosphorylation via a tyrosine kinase- and protein kinase C-dependent mechanism, Circ Res, 86, 989, 10.1161/01.RES.86.9.989

Bouma, 1997, The anti-inflammatory potential of adenosine in ischemia-reperfusion injury: Established and putative beneficial actions of a retaliatory metabolite, Shock, 8, 313, 10.1097/00024382-199711000-00001

Peralta, 2001, Preconditioning protects against systemic disorders associated with hepatic ischemia-reperfusion through blockade of tumor necrosis factor-induced P-selectin up-regulation in the rat, Hepatology, 33, 100, 10.1053/jhep.2001.20529

Downey, 1994, Cellular mechanisms in ischemic preconditioning: the role of adenosine and protein kinase C, Ann NY Acad Sci, 723, 82, 10.1111/j.1749-6632.1994.tb36719.x

Liu, 1994, Evidence that translocation of protein kinase C is a key event during ischemic preconditioning of rabbit myocardium, J Mol Cell Cardiol, 26, 661, 10.1006/jmcc.1994.1078

Downey, 1997, Arguments in favor of protein kinase C playing an important role in ischemic preconditioning, Basic Res Cardiol, 92, 37, 10.1007/BF00797205

Wolfrum, 2001, Apstatin, a selective inhibitor of aminopeptidase P, reduces myocardial infarct size by a kinin-dependent pathway, Br J Pharmacol, 134, 370, 10.1038/sj.bjp.0704236

Toombs, 1993, Ischemic preconditioning fails to limit infarct size in reserpinized rabbit myocardium, Circulation, 88, 2351, 10.1161/01.CIR.88.5.2351

de Zeeuw, 2001, Cardioprotection in pigs by exogenous norepinephrine but not by cerebral ischemia-induced release of endogenous norepinephrine, Stroke, 32, 767, 10.1161/01.STR.32.3.767

Hu, 1995, Mechanisms of ischemic preconditioning in rat hearts, Circulation, 92, 2259, 10.1161/01.CIR.92.8.2259

Zhang, 2001, Role of endogenous opioid peptides in protection of ischemic preconditioning in rat small intestine, Life Sci, 68, 1013, 10.1016/S0024-3205(00)01004-3

Zhang, 2006, Kappa-opioid receptors mediate cardioprotection by remote preconditioning, Anesthesiology, 105, 550, 10.1097/00000542-200609000-00019

Evans, 1995, Delta-opioid peptide receptors in muscles from obese diabetic and normal mice, Peptides, 16, 361, 10.1016/0196-9781(94)00185-5

Evans, 1997, Evidence for a hormonal action of beta-endorphin to increase glucose uptake in resting and contracting skeletal muscle, J Endocrinol, 155, 387, 10.1677/joe.0.1550387

Baines, 1999, Signal transduction in ischemic preconditioning: the role of kinases and mitochondrial K(ATP) channels, J Cardiovasc Electrophysiol, 10, 741, 10.1111/j.1540-8167.1999.tb00251.x

Baines, 1997, Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium, J Mol Cell Cardiol, 29, 207, 10.1006/jmcc.1996.0265

Pattwell, 2004, Release of reactive oxygen and nitrogen species from contracting skeletal muscle cells, Free Radic Biol Med, 37, 1064, 10.1016/j.freeradbiomed.2004.06.026

Chen, 2005, Heme oxygenase-2 protects against glutathione depletion-induced neuronal apoptosis mediated by bilirubin and cyclic GMP, Curr Neurovasc Res, 2, 121, 10.2174/1567202053586767

Mabanta, 2006, Initiation of remote microvascular preconditioning requires K(ATP) channel activity, Am J Physiol Heart Circ Physiol, 290, H264, 10.1152/ajpheart.00455.2005

Li, 1996, Calcitonin gene-related peptide-induced preconditioning protects against ischemia-reperfusion injury in isolated rat hearts, Eur J Pharmacol, 311, 163, 10.1016/0014-2999(96)00426-8

Tanaka, 1998, Expression of heat shock protein after ischemic preconditioning in rabbit hearts, Jpn Circ J, 62, 512, 10.1253/jcj.62.512

Amersi, 1999, Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury, J Clin Invest, 104, 1631, 10.1172/JCI7903

Coito, 2002, Heme oxygenase-1 gene transfer inhibits inducible nitric oxide synthase expression and protects genetically fat Zucker rat livers from ischemia-reperfusion injury, Transplantation, 74, 96, 10.1097/00007890-200207150-00017

Fondevila, 2003, Biliverdin protects rat livers from ischemia/reperfusion injury, Transplant Proc, 35, 1798, 10.1016/S0041-1345(03)00720-6

Katori, 2002, A novel strategy against ischemia and reperfusion injury: Cytoprotection with heme oxygenase system, Transpl Immunol, 9, 227, 10.1016/S0966-3274(02)00043-6

Lai, 2006, Transient limb ischemia induces remote preconditioning in liver among rats: The protective role of heme oxygenase-1, Transplantation, 81, 1311, 10.1097/01.tp.0000203555.14546.63

Konstantinov, 2004, The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans, Physiol Genom, 19, 143, 10.1152/physiolgenomics.00046.2004

Lang, 2006, Myocardial preconditioning and remote renal preconditioning—identifying a protective factor using proteomic methods?, Basic Res Cardiol, 101, 149, 10.1007/s00395-005-0565-0

Verdouw, 1996, Cardioprotection by ischemic and nonischemic myocardial stress and ischemia in remote organs, Ann NY Acad Sci, 793, 27, 10.1111/j.1749-6632.1996.tb33502.x

Huda, 2005, Ischemic preconditioning at a distance: Altered gene expression in mouse heart and other organs following brief occlusion of the mesenteric artery, Heart Lung Circ, 14, 36, 10.1016/j.hlc.2004.11.006

Liem, 2003, Transient limb ischemia induces remote ischemic preconditioning in vivo, Circulation, 107, e218, 10.1161/01.CIR.0000077520.36997.F9

Moses, 2005, Inducing late phase of infarct protection in skeletal muscle by remote preconditioning: Efficacy and mechanism, Am J Physiol Regul Integr Comp Physiol, 289, R1609, 10.1152/ajpregu.00395.2005