Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence

Travel Medicine and Infectious Disease - Tập 35 - Trang 101647 - 2020
Yuchen Cao1, Qixin Deng1, Shixue Dai2
1The Second Clinical School, Southern Medical University, Guangzhou, 510515, Guangdong, China
2Department of Gastroenterology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, South China University of Technology, Guangzhou, 510080, Guangdong, China

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Tài liệu tham khảo

Liu, 2020, Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV, Chembiochem, 21, 730, 10.1002/cbic.202000047

W, 2020, Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro, Cell Res, 30, 269, 10.1038/s41422-020-0282-0

L, 2020, [Potential antiviral therapeutics for 2019 novel coronavirus]., Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chin J Tubercul Respir Dis, 43, E2

Zhu, 2020, A novel coronavirus from patients with pneumonia in China, 2019, N Engl J Med, 382, 727, 10.1056/NEJMoa2001017

Chen, 2020, Emerging coronaviruses: genome structure, replication, and pathogenesis, J Med Virol, 92, 418, 10.1002/jmv.25681

Du, 2009, The spike protein of SARS-CoV — a target for vaccine and therapeutic development, Nat Rev Microbiol, 7, 226, 10.1038/nrmicro2090

Zhou, 2020, 2020

Qiu, 2020, Identification of potential cross-protective epitope between 2019-nCoV and SARS virus, J Genet Genom, S1673

Hoffmann, 2020, 2020

Xu, 2020, Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission, Sci China Life Sci, 63, 457, 10.1007/s11427-020-1637-5

Zhou, 2020, A pneumonia outbreak associated with a new coronavirus of probable bat origin, Nature, 579, 270, 10.1038/s41586-020-2012-7

Wrapp, 2020, 2020

Huang, 2020, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet (London, England), 395, 497, 10.1016/S0140-6736(20)30183-5

Chan, 2020, A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster, Lancet (London, England), 395, 514, 10.1016/S0140-6736(20)30154-9

Fan, 2020, 2020

Zhang, 2020, 2020

Wong, 2004, Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome, Clin Exp Immunol, 136, 95, 10.1111/j.1365-2249.2004.02415.x

Mahallawi, 2018, MERS-CoV infection in humans is associated with a pro-inflammatory Th1 and Th17 cytokine profile, Cytokine, 104, 8, 10.1016/j.cyto.2018.01.025

Xu, 2020, Pathological findings of COVID-19 associated with acute respiratory distress syndrome, The Lancet Respir Med, S2213

Zou, 2020, SARS-CoV-2 viral load in upper respiratory specimens of infected patients, N Engl J Med, 382, 1177, 10.1056/NEJMc2001737

L, 2019, Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge, Sci Transl Med, 11

Cj, 2020, The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus, J Biol Chem

Tp, 2020, Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV., Nat Commun, 11, 222, 10.1038/s41467-019-13940-6

de Wit, 2020, Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection, Proc Natl Acad Sci U S A, 117, 6771, 10.1073/pnas.1922083117

Warren, 2015, Nucleotide prodrug GS-5734 is a broad-spectrum filovirus inhibitor that provides complete therapeutic protection against the development of Ebola virus disease (EVD) in infected non-human primates, 139, 311

Appendix 4, 2018

M, 2019, A randomized, controlled trial of Ebola virus disease therapeutics, The New England journal of medicine, 381, 2293, 10.1056/NEJMoa1910993

B, 2017, The pathogenesis of Ebola virus disease, Annual review of pathology, 12, 387, 10.1146/annurev-pathol-052016-100506

W, 2016, Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys, Nature, 531, 381, 10.1038/nature17180

Jordan, 2018, Nucleosides for the treatment of respiratory RNA virus infections, Antivir Chem Chemother, 26, 10.1177/2040206618764483

Kim, 2020, The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: implication for infection prevention and control measures, J Kor Med Sci, 35, e61, 10.3346/jkms.2020.35.e61

Chen, 2020, COVID-19 control in China during mass population movements at New Year, Lancet, 395, 764, 10.1016/S0140-6736(20)30421-9

A, 2020, Remdesivir as a possible therapeutic option for the COVID-19., Trav Med Infect Dis

Pedersen, 2019, Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis, J Feline Med Surg, 21, 271, 10.1177/1098612X19825701

Ml, 2018, Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease, mBio, 9

C, 2012, Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides., Bioorg Med Chem Lett, 22, 2705, 10.1016/j.bmcl.2012.02.105