Relative contribution of DNA strand breaks and DNA adducts to the genotoxicity of benzo[a]pyrene as a pure compound and in complex mixtures

Adeline Tarantini1,2, Anne Maı̂tre1, Emmanuel Lefèbvre1, Marie Marquès1, Caroline Marie1,2, Jean‐Luc Ravanat2, Thierry Douki2
1Equipe EPSP Environnement et Prédiction de la Santé des Populations, laboratoire TIMC (UMR CNRS 5525), CHU de Grenoble, Université Joseph Fourier, Faculté de Médecine, Domaine de la Merci, 38700 La Tronche, France
2Laboratoire "Lésions des Acides Nucléiques", Service de Chimie Inorganique et Biologique UMR-E 3 CEA-UJF, CNRS FRE 3200, CEA/DSM/INAC, CEA-Grenoble, 38054 Grenoble, Cedex 9, France

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