Relationships Between Clinico-Epidemiological Patterns of Invasive Meningococcal Infections and Complement Deficiencies in French South Pacific Islands (New Caledonia)
Tóm tắt
Invasive Meningococcal Disease (IMD) is three fold more common in New Caledonia (NC) than in metropolitan France and many IMD cases (35.7 %) are due to Y and W135 serogroups. The purpose of our study was to identify IMD risk factors in NC. A retrospective study of all IMD cases that occurred in NC between 2005 and 2011 was conducted. Socio-environmental, clinical and biological data were collected. A search for immune deficiency was proposed to all cases. IMD presentation and outcome were compared according to meningoccal serogroups and the complement deficiency status (C-deficiency). Sixty-six sporadic IMD cases (29 B serogroup, 20 Y or W135, 6 C, 1 A, 10 unknown) occurred in 64 patients often <24 years-old and of Melanesian origin. Five patients died (7.8 %). No socio-environmental risk factors were identified. No asplenia, HIV infection or immunoglobulin deficiencies were found. Two patients had diabetes and 28 of 53 (52.8 %) patients had C-deficiency including 20 (71.4 %) cases of late complement component deficiency. Patients with C-deficiency were mainly Melanesian (92.8 %) originating from the Loyalty Islands (62.1 %). They were mostly infected with Y/W135 (42.9 %) or B serogroups (32.1 %). They often developed later and more severe disease than patients without C-deficiency (need for intensive cares in 60 % versus 28.0 % of cases, p = 0.01). A high prevalence of C-deficiency in the Melanesian population may explain epidemiological and clinical features of IMD in NC. Our results imply an adaptation of meningococcal vaccine strategies in NC.
Tài liệu tham khảo
Pollard AJ. Global epidemiology of meningococcal disease and vaccine efficacy. Pediatr Infect Dis J. 2004;23(12 Suppl):S274–9.
Caro JJ, Möller J, Getsios D, et al. Invasive meningococcal disease epidemiology and control measures: a framework for evaluation. BMC Public Health. 2007;7:130.
World Health Organization. Control of epidemic meningococcal disease. WHO practical guidelines. 2nd edition WHO/EMC/BAC/98.3. Available at: http://www.who.int/csr/resources/publications/meningitis/whoemcbac983.pdf. Accessed 1998.
Harrison LH, Trotter CL, Ramsay ME. Global epidemiology of meningococcal disease. Vaccine. 2009;27 Suppl 2:B51–63. doi:10.1016/j.vaccine.2009.04.063. Review.
Jones DM, Mallard RH. Age incidence of meningococcal infection England and Wales, 1984–1991. J Infect. 1993;27:83–8.
McCall BJ, Neill AS, Young MM. Risk factors for invasive meningococcal disease in southern Queensland, 2000–2001. Intern Med J. 2004;34(8):464–8.
Fischer M, Hedberg K, Cardosi P, et al. Tobacco smoke as a risk factor for meningococcal disease. Pediatr Infect Dis J. 1997;16(10):979–83.
Kriz P, Bobak M, Kriz B. Parental smoking, socioeconomic factors, and risk of invasive meningococcal disease in children: a population based case–control study. Arch Dis Child. 2000;83(2):117–21.
Stanwell-Smith RE, Stuart JM, Hughes AO, Robinson P, Griffin MB, Cartwright K. Smoking, the environment and meningococcal disease: a case control study. Epidemiol Infect. 1994;112(2):315–28.
Deutch S, Labouriau R, Schønheyeder HC, et al. Crowding as a risk factor of meningococcal disease in Danish preschool children: a nationwide population-based case–control study. Scand J Infect Dis. 2004;36(1):20–3.
Baker M, McNicholas A, Garrett N, et al. Household crowding a major risk factor for epidemic meningococcal disease in Auckland children. Pediatr Infect Dis J. 2000;19(10):983–90.
Kallel-Sellami M, Abdelmalek R, Zerzeri Y, et al. Complement protein hereditary deficits during purulent meningitis: study of 61 adult Tunisian patients. Arch Inst Pasteur Tunis. 2006;83(1–4):25–34. French.
Densen P. Complement deficiencies and meningococcal disease. Clin Exp Immunol. 1991;86 Suppl 1:57–62. Review.
Bona G, Guidi C. Meningococcal vaccine evolution. J Prev Med Hyg. 2012;53(3):131–5.
Ross SC, Densen P. Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency. Medicine (Baltimore). 1984;63:243–73.
Overturf GD. Indications for the immunological evaluation of patients with meningitis. Clin Infect Dis. 2003;36:189–94.
Ellison 3rd RT, Kohler PF, Curd JG, Judson FN, Reller LB. Prevalence of congenital or acquired complement deficiency in patients with sporadic meningocococcal disease. N Engl J Med. 1983;308(16):913–6.
Revest M, Michelet C. Predisposing factors of community acquired bacterial meningitis (excluding neonates). Med Mal Infect. 2009;39(7–8):562–71.
Skattum L, van Deuren M, van der Poll T, Truedsson L. Complement deficiency states and associated infections. Mol Immunol. 2011;48(14):1643–55.
Fijen CAP, Kuijper EJ, Tjia HG, Daha MR, Dankert J. Complement deficiency predisposes for meningitis due to nongroupable meningococci and Neisseria-related bacteria. Clin Infect Dis. 1994;18:780–4.
Fijen CA, van den Bogaard R, Schipper M, et al. Properdin deficiency: molecular basis and disease association. Mol Immunol. 1999;36(13–14):863–7.
Nielsen HE, Koch C, Magnussen P, Lind I. Complement deficiencies in selected groups of patients with meningococcal disease. Scand J Infect Dis. 1989;21:389–96.
Sjöholm AG, Jönsson G, Braconier JH, Sturfelt G, Truedsson L. Complement deficiency and disease: an update. Mol Immunol. 2006;43:78–85.
Figueroa JE, Densen P. Infectious diseases associated with complement deficiencies. Clin Microbiol Rev. 1991;4(3):359–95.
Platonov AE, Vershinina IV, Käyhty H, Fijen CA, Würzner R, Kuijper EJ. Antibody-dependent killing of meningococci by human neutrophils in serum of late complement component deficient patients. Int Arch Allergy Immunol. 2003;130:314–21.
Parent du Châtelet I, Taha M-K, Lepoutre A, Deghmane A-E, Maine C, Lévy-Bruhl D. Invasive meningococcal disease in France, 2009. Weekly epidemiological bulletin (B.E.H) of French National Institute for Public Health Surveillance (InVS) n° 31–32. French. Available at: http://www.invs.sante.fr/beh/2010/31_32/. Accessed 27 July 2010.
Noel M Invasive meningococcal disease in New Caledonia: epidemiology and comparison of strains B with existing vaccine strains. Diplomae of vaccinology. University of Victor Segalen, Bordeaux 2, French New-caledonia 2010.
French Ministry of Health and Sports. National recommendations and policy regarding prophylaxis of invasive meningococcal diseases (DGS/5C/2006/458). Paris: 2006. French. Available at: http://www.infectiologie.com/site/medias/_documents/officiels/meningo_circ_2006.pdf. Accessed 23 Oct 2006.
Botto M, Kirschfink M, Macor P, Pickering MC, Würzner R, Tdesco F. Complement in human diseases: lessons from complement deficiencies. Mol Immunol. 2009;46:2774–83.
Nagata M, Hara T, Aoki T, et al. Inherited deficiency of ninth component of complement: an increased risk of meningococcal meningitis. J Pediatr. 1989;114(2):260–4.
Rameix-Welti MA, Chedani H, Blouin J, Alonso JM, Fridman WH, Fremeaux-Bacchi V. Neisseria meningitidis infection. Clinical criteria orienting towards a deficiency in the proteins of the complement. Presse Med. 2005;34(6):425–30. French.
Mayatepek E, Grauer M, Hänsch GM, Sonntag HG. Deafness, complement deficiencies and immunoglobulin status in patients with meningococcal diseases due to uncommon serogroups. Pediatr Infect Dis J. 1993;12(10):808–11.
Tedesco F. Inherited complement deficiencies and bacterial infections. Vaccine. 2008;26 suppl 8:13–8.
Fijen CAP, Kuijper EJ, Drogari-Apiranthitou M, Van Leeuwen Y, Daha MR, Dankert J. Protection against meningococcal serogroup ACYW disease in complement-deficient individuals vaccinated with the tetravalent meningococcal capsular polysaccharide vaccine. Clin Exp Immunol. 1998;114:362–9.
Rameix-Welti MA, Régnier CH, Bienaimé F, Blouin J, Schifferli J, Fridman WH, et al. Hereditary complement C7 deficiency in nine families: Subtotal C7 deficiency revisited. Eur J Immunol. 2007;37:1377–85.
Høgåsen K, Michaelsen T, Mellbye OJ, Bjune G. Low prevalence of complement deficiencies among patients with meningococcal disease in Norway. Scand J Immunol. 1993;37(4):487–9.
Ernst T, Späth PJ, Aebi C, Schaad UB, Bianchetti MG. Screening for complement deficiency in bacterial meningitis. Acta Paediatr. 1997;86(9):1009–10.
Fijen CA, Kuijper EJ, te Bulte MT, Daha MR, Dankert J. Assessment of complement deficiency in patients with meningococcal disease in The Netherlands. Clin Infect Dis. 1999;28(1):98–105.