Relationships Between Beliefs about Medications and Nonadherence to Prescribed Chronic Medications

Annals of Pharmacotherapy - Tập 40 Số 10 - Trang 1737-1742 - 2006
Hemant Phatak1,2, Joseph Thomas3
1Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN
2Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN; now, Rutgers-Merck Research Associate, Department of Pharmacy Practice and Administration, Rutgers: The State University of New Jersey, Piscataway, NJ
3Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Purdue University

Tóm tắt

Background: Medication beliefs of patients with a specific medical condition have been associated with nonadherence to drugs used to treat that condition. However, associations between medication beliefs and nonadherence of individuals on chronic, multiple medications have not been studied. Objective: To investigate associations between patients' medication beliefs and nonadherence to chronic drug therapy. Methods: A cross-sectional, self-administered survey of patients waiting to see pharmacists at an outpatient pharmacy in a primary care clinic was conducted. Participants' medication beliefs were assessed using the Beliefs about Medicines Questionnaire, and nonadherence was assessed using the Morisky Medication Adherence Scale. Pearson correlation analysis was used to assess bivariate associations between medication beliefs and nonadherence. Regression was used to assess relative strength of associations between various medication beliefs and nonadherence and also to assess the significance of the interactions between those beliefs and nonadherence. Results: There were positive bivariate associations between specific concerns about medications (p < 0.001), perceived general harmful effects of medications (p < 0.001), and perceived overprescribing of medications by physicians (p < 0.001) and medication nonadherence. When relative strength of associations between each medication belief and nonadherence was assessed, while controlling for other medication beliefs, specific–necessity (p = 0.02) and specific–concerns (p = 0.01) exhibited significant negative and positive associations with nonadherence, respectively. All two-way interactions between variables in the model were insignificant. A model consisting of age, total number of drugs used, and medication beliefs, that is, specific–necessity, specific–concerns, general–overuse, and general–harm, accounted for 26.5% of variance. Medication beliefs alone explained 22.4% of variation in nonadherence to chronic drug therapy. Conclusions: Patients' medication beliefs explained a significant portion of variation in medication nonadherence.

Từ khóa


Tài liệu tham khảo

10.1056/NEJMra050100

Leventhal H, 1980, Medical psychology, 1, 7

10.1007/BF01173486

10.1177/002570879204900403

10.1080/09540120020014237

10.1136/bmj.312.7040.1191

10.1097/01.mlr.0000185733.30697.f6

10.1345/aph.1G249

10.1016/S0022-3999(99)00057-4

10.1016/S0022-3999(99)00058-6

10.1080/08870449908407311

10.1016/S0277-9536(96)00333-4

10.1016/S1056-8727(97)00075-5

10.1136/bmj.325.7369.873

10.1080/09540120050123783

Horne R., 1997, Perceptions of health and illness: advances in theory and measurement, 155

10.1016/j.jpsychores.2004.11.010

10.1016/S0277-9536(03)00232-6

10.1345/aph.1D252

10.1097/00126334-200202011-00002

10.1097/00005650-200209000-00009

Morisky DE, 2001, Presented at: 129th meeting of the American Pharmacy Association, 21

10.1089/apc.2005.19.306

10.1001/jama.1993.03510060088038

Rogers PG, 1995, J Pharmacoepidemiology, 2, 3

Haynes RB, 2003, The Cochrane Library, 4, 1

10.1111/j.1547-5069.2001.00211.x

10.1080/0954012021000039815

Thông tin
Thông tin xuất bản

Annals of Pharmacotherapy

Tập 40 Số 10

1737-1742

Thông tin tác giả