Mối quan hệ giữa Estrogen huyết thanh và các chất chuyển hóa với mật độ Mammography theo diện tích và thể tích

Gretchen L. Gierach1,2, Deesha A. Patel1, Roni T. Falk1, Ruth M. Pfeiffer3, Berta M. Geller4, Pamela M. Vacek4, Donald L. Weaver4, Rachael E. Chicoine4, John A. Shepherd5, Amir Pasha Mahmoudzadeh5, Jeff Wang5,6, Bo Fan5, Sally D. Herschorn4, Xia Xu7, Timothy Veenstra7,8, Barbara Fuhrman9, Mark E. Sherman10, Louise A. Brinton1
1Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
2Bethesda, USA
3Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, USA
4University of Vermont , Burlington, USA
5University of California San Francisco, San Francisco, USA
6Graduate School of Medicine, Hokkaido University, Sapporo, Japan
7Laboratory of Proteomics and Analytical Technologies, Cancer Research Technology Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA
8CN Diagnostics, Saint Louis, USA
9Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, USA
10Breast and Gynecologic Cancer Research Group, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, USA

Tóm tắt

Mật độ mammogram cao là một yếu tố nguy cơ của ung thư vú, có mối liên hệ gợi ý nhưng chưa được chứng minh với việc tăng cường tiếp xúc với hormone steroid giới tính. Chúng tôi đã khảo sát mối liên hệ của estrogen và các chất chuyển hóa estrogen trong huyết thanh với các chỉ số mật độ mammogram theo diện tích và thể tích mới ở 187 phụ nữ, trong độ tuổi 40–65, đang tiến hành sinh thiết vú chẩn đoán tại một cơ sở học thuật ở Vermont. Estrogen mẹ trong huyết thanh, estrone và estradiol, cùng với các chất chuyển hóa hydroxy hóa tại vị trí 2-, 4- và 16- đã được đo lường bằng phương pháp sắc ký lỏng kết hợp khối phổ. Mật độ mammogram theo diện tích được đo lường ở vú không làm sinh thiết bằng phần mềm ngưỡng; mật độ mammogram theo thể tích được định lượng bằng mô hình mật độ. Hồi quy tuyến tính được sử dụng để ước tính mối liên hệ giữa estrogen với mật độ mammogram, được điều chỉnh theo tuổi và chỉ số khối cơ thể, và phân tách theo trạng thái mãn kinh và giai đoạn chu kỳ kinh nguyệt. Các mối liên hệ yếu, tích cực giữa estrogen, các chất chuyển hóa estrogen và mật độ mammogram đã được quan sát, chủ yếu ở phụ nữ mãn kinh. Ở nhóm phụ nữ tiền mãn kinh trong giai đoạn hoàng thể, chất chuyển hóa theo đường 16, estriol, đã liên quan đến phần trăm diện tích (p = 0.04) và thể tích (p = 0.05) mật độ mammogram cũng như diện tích tuyệt đối (p = 0.02) và thể tích (p = 0.05). Ở phụ nữ mãn kinh, mức độ estrogen tổng hợp, tổng của estrogen mẹ, và các chất chuyển hóa trên các con đường hydroxyl hóa 2-, 4- và 16- có mối tương quan tích cực với các chỉ số mật độ theo diện tích (phần trăm: p = 0.03, p = 0.04, p = 0.01, p = 0.02, p = 0.07; tuyệt đối: p = 0.02, p = 0.02, p = 0.01, p = 0.02, p = 0.03) nhưng không phải là các chỉ số mật độ theo thể tích. Dữ liệu của chúng tôi gợi ý rằng hồ sơ estrogen trong huyết thanh là những yếu tố xác định yếu của mật độ mammogram và rằng phân tích các chỉ số mật độ khác nhau có thể cung cấp thông tin bổ sung về mối quan hệ giữa tiếp xúc estrogen và thành phần mô vú.

Từ khóa

#mật độ mammogram #estrogen huyết thanh #chất chuyển hóa estrogen #ung thư vú #phụ nữ tiền mãn kinh #phụ nữ mãn kinh

Tài liệu tham khảo

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