Relationship of Activity in the Subthalamic Nucleus–Globus Pallidus Network to Cortical Electroencephalogram
Tóm tắt
One of the functions of the excitatory subthalamic nucleus (STN) is to relay cortical activity to other basal ganglia structures. The response of the STN to cortical input is shaped by inhibition from the reciprocally connected globus pallidus (GP). To examine the activity in the STN–GP network in relation to cortical activity, we recorded single and multiple unit activity in STN and/or GP together with cortical electroencephalogram in anesthetized rats during various states of cortical activation.
During cortical slow-wave activity (SWA), STN and GP neurons fired bursts of action potentials at frequencies that were similar to those of coincident slow (∼1 Hz) and spindle (7–14 Hz) cortical oscillations. Spontaneous or sensory-driven global activation was associated with a reduction of SWA and a shift in STN–GP activity from burst- to tonic- or irregular-firing. Rhythmic activity in STN and GP neurons was lost when the cortex was inactivated by spreading depression and did not resume until SWA had recovered.
Although rhythmic STN–GP activity was correlated with SWA, the phase relationships of activities of neurons within the STN and GP and between the nuclei were variable. Even when neurons displayed synchronous bursting activity, correlations on the millisecond time scale, which might indicate shared synaptic input, were not observed.
These data indicate that (1) STN and GP activity is intimately related to cortical activity and hence the sleep–wake cycle; (2) rhythmic oscillatory activity in the STN–GP network in disease states may be driven by the cortex; and (3) activity of the STN–GP network is regulated in space in a complex manner.
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Tài liệu tham khảo
Albe-Fessard D Condes-Lara M Kesar S Sanderson P (1983) Tonic cortical controls acting on spontaneous and evoked thalamic activity. in Somatosensory integration in the thalamus, eds Macchi G Rustioni A Spreafico R (Elsevier, Amsterdam), pp 273–285.
Armstrong-James, 1983, Similarities in unitary cortical activity between slow-wave sleep and light urethane anaesthesia in the rat., J Physiol (Lond), 346, 55P
Bergman, 1989, Electro-physiological studies of the connections between the subthalamic nucleus (STN) and globus pallidus (GP) in behaving monkeys., Soc Neurosci Abstr, 15, 902
Bergman, 1994, The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of Parkinsonism., J Neurophysiol, 72, 507, 10.1152/jn.1994.72.2.507
Bringmann, 1995, Different functions of rat's pedunculopontine tegmental nucleus are reflected in cortical EEG., NeuroReport, 6, 2065, 10.1097/00001756-199510010-00026
Buchwald, 1961, The “caudate-spindle.” I. Electrophysiological properties., Electroencephalogr Clin Neurophysiol, 13, 509, 10.1016/0013-4694(61)90164-X
Evarts, 1964, Temporal patterns of discharge of pyramidal tract neurons during sleep and waking in the monkey., J Neurophysiol, 27, 152, 10.1152/jn.1964.27.2.152
Fujimoto, 1992, Response of rat substantia nigra pars reticulata units to cortical stimulation., Brain Res, 142, 105
Kaneoke, 1996, Burst and oscillation as disparate neuronal properties., J Neurosci Methods, 68, 221, 10.1016/0165-0270(96)00081-7
Morison, 1945, Electrical activity of the thalamus and basal ganglia in decorticate cats., J Neurophysiol, 8, 309, 10.1152/jn.1945.8.5.309
Nambu, 1994, Electrophysiology of globus pallidus neurons in vitro., J Neurophysiol, 72, 1127, 10.1152/jn.1994.72.3.1127
Nini, 1995, Neurons in the globus pallidus do not show correlated activity in the normal monkey, but phase-locked oscillations appear in the MPTP model of Parkinsonism., J Neurophysiol, 74, 1800, 10.1152/jn.1995.74.4.1800
Paxinos G Watson C (1986) The rat brain in stereotaxic coordinates, Ed 2. (Academic, Sydney).
Plenz, 1997, The oscillatory feedback circuitry between subthalamic nucleus and globus pallidus as a putative generator for resting tremor., Soc Neurosci Abstr, 23, 463
Ruskin, 1999, Multisecond oscillations in firing rate in the basal ganglia: robust modulation by dopamine receptor activation and anesthesia., J Neurophysiol, 81, 2046, 10.1152/jn.1999.81.5.2046
Ryan, 1991, The role of the subthalamic nucleus in the response of globus pallidus neurons to stimulation of the prelimbic and agranular frontal cortices in rats., Exp Brain Res, 86, 641, 10.1007/BF00230538
Ryan, 1992, Auto- and cross-correlation analysis of subthalamic nucleus neuronal activity in neostriatal- and globus pallidal-lesioned rats., Brain Res, 583, 253, 10.1016/S0006-8993(10)80031-9
Steriade, 1998, Coalescence of sleep rhythms and their chronology in corticothalamic networks., Sleep Res Online, 1, 1
Steriade M Jones EG Llinás RR (1990) Thalamic oscillations and signaling. (Wiley-Interscience, New York).
Steriade, 1993, Cholinergic and noradrenergic modulation of the slow (≈ 0.3 Hz) oscillation in neocortical cells., J Neurophysiol, 70, 1385, 10.1152/jn.1993.70.4.1385