Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients

Brain and Behavior - Tập 8 Số 2 - 2018
Qiongzhang Wang1, Zhuoying Zhu1, Yuntao Liu1, Xinjie Tu1, Jincai He1
1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China

Tóm tắt

AbstractIntroductionLow serum vitamin D levels are associated with the development of poststroke depression (PSD). Inflammatory markers play an important role in pathophysiology of PSD. The relationship between vitamin D levels and inflammatory markers has been discussed in nonstroke individuals. The purposes of this study were to explore the relationship between vitamin D levels and inflammatory markers in acute stroke patients and examine the effect of vitamin D and inflammatory markers on PSD.MethodsA total of 152 acute stroke patients were recruited. Serum levels of 25‐hydroxyvitamin D and inflammatory markers were measured by standardized laboratory methods. Depression symptoms were assessed with the 17‐item Hamilton Depression Scale (HAMD‐17). Patients with theHAMD‐17 scores ≥7 were identified to have depression symptoms.ResultsSerum vitamin D levels were negatively correlated with serum levels of interleukin‐6 and high‐sensitivity C‐reactive protein (hsCRP) (r = −.244,p = .002;r = −.231,p = .004). Multiple regression analysis showed that interleukin‐6 and hsCRP levels were associated with vitamin D levels (B = −0.355,p = .003;B = −2.085,p = .006), whereas age, height, weight, leukocyte count, neutrophil ratio, and lymphocyte rate could be omitted without changing the results. In multivariate analyses, the serum levels of vitamin D and interleukin‐6 were associated with the development of PSD after adjusted possible variables (OR = 0.976, 95%CI: 0.958–0.994,p = .009;OR = 1.029, 95%CI: 1.003–1.055,p = .027).ConclusionsSerum vitamin D levels are inversely associated with the levels of interleukin‐6 and hsCRP, suggesting a potential anti‐inflammatory role for vitamin D in stroke individuals.

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Tài liệu tham khảo

10.1016/j.bbi.2017.06.005

10.1111/j.1749-6632.2003.tb06057.x

Afshari L., 2015, The relation between serum vitamin D levels and body antioxidant status in ischemic stroke patients: A case–control study, Advanced Biomedical Research, 4, 213, 10.4103/2277-9175.166150

10.1210/jc.2004-1667

10.1007/s11011-016-9939-2

Alharbi F. M., 2015, Update in vitamin D and multiple sclerosis, Neurosciences, 20, 329, 10.17712/nsj.2015.4.20150357

10.1002/pmic.200600392

10.1016/0039-128X(87)90079-1

10.1161/01.STR.0000089920.93927.A7

Azizieh F. Y., 2017, Association of self‐reported symptoms with serum levels of vitamin D and multivariate cytokine profile in healthy women, Journal of Inflammation Research, 10, 19, 10.2147/JIR.S127892

10.1038/nm.3268

Bani‐issa W., 2017, Vitamin D deficiency and its determinants in adults: A sample from community‐based settings in the United Arab Emirates, International Journal of Endocrinology, 2017, 3906306, 10.1155/2017/3906306

Berridge M. J., 2017, Vitamin D deficiency and diabetes, Biochemical Journal, 474, 1321, 10.1042/BCJ20170042

10.1016/j.cct.2014.10.004

10.1136/thx.2007.090027

Bicikova M., 2015, Vitamin D in anxiety and affective disorders, Physiological Research, 64, S101, 10.33549/physiolres.933082

10.1589/jpts.28.2159

10.1097/00006842-200207000-00010

10.1093/ajcn/88.2.483S

10.1016/j.schres.2014.08.031

10.1016/j.cyto.2011.09.013

10.1111/j.1365-2265.2011.04320.x

10.1007/s11357-014-9694-4

10.1001/archinte.168.12.1340

10.1016/j.nefro.2017.03.028

10.1097/01.nrl.0000215789.70804.b0

Elkind M. S., 2001, Elevated white blood cell count and carotid plaque thickness—the Northern Manhattan Stroke Study, Stroke, 32, 842, 10.1161/01.STR.32.4.842

10.1111/j.1365-2249.2005.02961.x

10.1016/j.jsbmb.2006.12.096

10.1016/j.neuroscience.2014.02.042

10.1016/S0140-6736(07)61896-0

10.1007/BF03347358

10.1016/j.diabres.2006.10.007

10.1038/ejcn.2013.48

10.1016/0049-3848(96)00071-0

Haidari F., 2016, Comparison of serum levels of vitamin D and inflammatory markers between women with gestational diabetes mellitus and healthy pregnant control, Journal of Family & Reproductive Health, 10, 1

10.1111/ene.12607

10.1017/S0033291712000128

10.1016/S0006-8993(98)01140-8

Holick M. F., 1992, Evolutionary biology and pathology of vitamin D, Journal of Nutritional Science and Vitaminology, 79, 10.3177/jnsv.38.Special_79

10.2174/138945011793591635

Hossein‐Nezhad A., 2013, Evidences of dual role of vitamin D through cellular energy homeostasis and inflammation pathway in risk of cancer in obese subjects, Minerva Medica, 104, 295

10.3177/jnsv.63.1

10.1161/HYPERTENSIONAHA.110.160929

Jimenez I., 2009, High serum levels of leptin are associated with post‐stroke depression, Psychological Medicine, 39, 1201, 10.1017/S0033291709005637

10.1111/ene.12938

10.1016/j.psyneuen.2016.07.001

10.1111/j.1365-2249.2010.04315.x

10.1006/cyto.2002.0895

Kubera M., 2000, Plasma levels of interleukin‐6, interleukin‐10, and interleukin‐1 receptor antagonist in depression: Comparison between the acute state and after remission, Polish Journal of Pharmacology, 52, 237

Kulie T., 2010, Vitamin D: An evidence‐based review (vol 22, pg 698, 2009), Journal of the American Board of Family Medicine, 23, 138, 10.3122/jabfm.2010.01.090256

10.1210/jc.2013-3507

10.1016/j.neulet.2003.12.041

10.3961/jpmph.15.042

10.1016/S0304-3940(00)00907-1

10.1371/journal.pone.0099805

10.1371/journal.pone.0178879

10.1016/j.cell.2010.03.006

10.1016/j.psychres.2017.05.012

10.1016/S0002-9149(02)02863-1

Mocanu V., 2013, Current status in vitamin D and regulatory T cells–immunological implications, Revista Medico‐Chirurgicala A Societatii de Medici si Naturalisti din Iasi, 117, 965

10.1097/01.psy.0000149259.72488.09

10.1161/01.STR.30.5.981

10.1007/s10238-013-0249-2

10.1016/j.amjmed.2009.09.024

10.1016/j.jad.2016.08.082

10.1016/j.autrev.2017.07.004

10.1186/1476-9255-5-10

10.1038/nrcardio.2016.73

10.1161/01.STR.0000062346.70983.DF

Prentice R. L., 1982, Leukocyte counts and cerebrovascular disease, Journal of Chronic Diseases, 35, 703, 10.1016/0021-9681(82)90094-7

10.3390/nu5072502

Raison C. L., 2013, Role of inflammation in depression: Implications for phenomenology, pathophysiology and treatment, Modern Trends in Pharmacopsychiatry, 28, 33, 10.1159/000343966

10.1016/S0304-3940(02)00169-6

Ridker P. M., 1999, Hot papers—Heart disease—Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men by P.M. Ridker, M. Cushman, M.J. Stampfer, R.P. Tracy, C.H. Hennekens—Comments, The Scientist, 13, 14

10.1176/appi.ajp.2015.15030363

10.1111/j.1365-2796.1993.tb00730.x

Salonen R., 1990, Progression of carotid atherosclerosis and its determinants: A population‐based ultrasonography study, Atherosclerosis, 81, 33, 10.1016/0021-9150(90)90056-O

Scola G., 2014, Current state of biomarkers in bipolar disorder, Current Psychiatry Reports, 16, 514, 10.1007/s11920-014-0514-4

Serdar M. A., 2017, Analysis of changes in parathyroid hormone and 25 (Oh) vitamin D levels with respect to age, gender and season: A data mining study, Journal of Medical Biochemistry, 36, 73, 10.1515/jomb-2017-0002

10.1093/aje/kwm306

10.1186/1742-2094-8-56

10.1038/sj.mp.4001879

Spalletta G., 2013, Neuropsychiatric symptoms and interleukin‐6 serum levels in acute stroke, Journal of Neuropsychiatry and Clinical Neurosciences, 25, 255, 10.1176/appi.neuropsych.12120399

10.1016/j.genhosppsych.2011.09.020

10.1016/j.jsbmb.2008.12.004

10.1002/jcb.26084

10.1016/bs.afnr.2015.06.003

10.1081/IPH-120014721

10.1161/01.STR.26.8.1393

10.1016/j.schres.2014.07.025

10.1007/s00213-003-1566-z

Tuttolomondo A., 2012, Arterial stiffness and ischemic stroke in subjects with and without metabolic syndrome, Atherosclerosis, 225, 216, 10.1016/j.atherosclerosis.2012.08.027

10.1097/MD.0000000000000813

10.1007/s12020-010-9379-4

10.1016/j.abb.2011.11.006

10.2353/ajpath.2010.090998

10.1155/2013/802165

10.1034/j.1600-0404.2001.00053.x

10.1097/MD.0000000000005208

10.1016/S0022-510X(97)00154-8

10.4049/jimmunol.1102412

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Brain and Behavior

Tập 8 Số 2

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