Relationship between occult hepatitis B virus infection and chronic kidney disease in a Chinese population‐based cohort

Chronic Diseases and Translational Medicine - Tập 2 - Trang 55-60 - 2016
Xiang-Lei Kong1, Xiao-Jing Ma2, Hong Su1, Dong-Mei Xu1
1Department of Nephrology, Qianfoshan Hospital, Shandong University, No.16766, Jingshi Road, Jinan, China
2Department of Health Examination Center, Qianfoshan Hospital, Shandong University, No.16766, Jingshi Road, Jinan, China

Tóm tắt

AbstractObjectivePrevious studies have revealed inconsistent results regarding the association between occult hepatitis B virus (HBV) infection and chronic kidney disease (CKD). Therefore, we conducted a prospective cohort study to evaluate the association between occult HBV infection and CKD.MethodsA total of 4329 adults, aged 46.2 ± 13.7 years, without CKD at baseline were enrolled while undergoing physical examinations. Occult HBV infection was defined as seropositivity for antibody to HBV core antigen. CKD was defined as decreased estimated glomerular filtration rate (eGFR < 60 ml·min−1·1.73 m−2) or presence of proteinuria ≥1+, assessed using a repeated dipstick method. eGFR was computed using the Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) equation.ResultsThe prevalence of occult HBV infection was 8.1% (352/4329). During 5 years of follow‐up, 165 patients (3.8%) developed CKD. Univariate Logistic regression analysis showed that occult HBV infection was positively associated with decreased eGFR, with an odds ratio (OR) of 2.15 (95% confidence interval (CI): 1.05–4.11). In contrast, occult HBV infection was not associated with either proteinuria or CKD (P > 0.05). After adjustment for potential confounders in the multivariate Logistic regression analysis, age, hypertension, diabetes, and the highest quartile of uric acid were associated with CKD, with ORs of 1.04 (95% CI: 1.02–1.05), 2.1 (95% CI: 1.46–3.01), 2.02 (95% CI: 1.36–2.99), and 1.86 (95% CI: 1.17–2.95), respectively. However, occult HBV infection was not associated with CKD, with an OR of 1.12 (95% CI: 0.65–1.95).ConclusionsThis study did not find an association between occult HBV infection and CKD. However, high‐risk patients infected with HBV should still be targeted for monitoring for the development of CKD.

Tài liệu tham khảo

10.1016/S0140-6736(05)17789-7 10.1159/000321382 10.1016/S0140-6736(12)60033-6 10.1016/j.ejim.2010.11.005 Zhou Y.H., 2009, Vaccination against hepatitis B: the Chinese experience, Chin Med J, 122, 98 10.1016/S0140-6736(71)92572-4 10.1016/S0140-6736(78)91801-9 10.1038/ki.1990.32 10.1056/NEJM199105233242103 10.1111/j.1523-1755.2005.00591.x 10.1016/j.jhep.2005.05.029 10.1007/s00125-006-0294-4 10.1038/ki.2014.363 10.1177/0300060514541828 10.1053/j.ajkd.2010.01.015 10.1186/s12882-015-0065-x 10.1111/j.1872-034X.2008.00334.x 10.1159/000077065 10.7326/0003-4819-150-9-200905050-00006 10.1093/ndt/gfs491 National Kidney Foundation, 2002, K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification, Am J Kidney Dis, 39, S1 10.1111/liv.12480 10.2215/CJN.05600612 10.2215/CJN.07410711 10.1186/s12882-015-0106-5 Germuth F.G., 1979, Passive immune complex glomerulonephritis in mice: models for various lesions found in human disease. II. Low avidity complexes and diffuse proliferative glomerulonephritis with subepithelial deposits, Lab Invest, 41, 366 10.1016/j.cyto.2004.07.007 10.1159/000093632 10.3748/wjg.v12.i11.1752 10.1038/ki.2013.249 10.1038/nrgastro.2014.30
Thông tin
Thông tin xuất bản

Chronic Diseases and Translational Medicine

Tập 2

55-60

Thông tin tác giả