Relationship between infant weight gain and later asthma

Pediatric Allergy and Immunology - Tập 21 Số 1-Part-I - Trang 82-89 - 2010
Ian M. Paul1, Lindsay J. Camera1, Robert S. Zeiger2,3, Theresa W. Guilbert4, Leonard B. Bacharier5, Lynn M. Taussig6, Wayne J. Morgan7, Ronina Covar8, Marzena Krawiec8, Gordon R. Bloomberg5, David T. Mauger1
1Department of Pediatrics and Public Health Science Penn State College of Medicine, Hershey, PA, USA
2Department of Pediatrics, Kaiser Permanente Southern California Region, San Diego, CA, USA
3Department of Pediatrics, University of California San Diego, La Jolla, CA
4Department of Pediatrics, University of Wisconsin, Madison, WI, USA
5Department of Pediatrics, Washington University School of Medicine, St. Louis, Mo. USA
6University of Denver, Denver, CO, USA
7Department of the Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ, USA
8Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO, USA

Tóm tắt

Paul IM, Camera L, Zeiger RS, Guilbert TW, Bacharier LB, Taussig LM, Morgan WJ, Covar RA, Krawiec M, Bloomberg GR, Mauger DT, for the Childhood Asthma Research and Education (CARE) Network. Relationship between infant weight gain and later asthma.
Pediatr Allergy Immunol 2010: 21: 82–89.
© 2009 John Wiley & Sons A/SLike obesity, the prevalence of asthma has increased over the past several decades. Accelerated patterns of infant growth have been associated with obesity and its co‐morbidities. We aimed to determine if infant weight gain pattern is associated with asthma development later in childhood. Birth weight, growth, pulmonary function, and symptom data were collected in a trial of 2‐ to 3‐yr‐old children at‐risk for asthma randomized to a 2‐yr treatment with inhaled corticosteroids or placebo followed by a 1‐yr observation period of study medication. Patterns of infant weight gain between birth and study enrollment were categorized as accelerated, average, or decelerated. Regression analyses were used to test the effects of infant weight gain pattern prior to study enrollment on outcomes during the observation year and at study conclusion while adjusting for demographics, baseline symptom severity, study treatment, and atopic indicators. Among the 197 study participants, early life weight gain pattern was not associated with daily asthma symptoms or lung function at the study’s conclusion. However, both prednisone courses (p = 0.01) and urgent physician visits (p < 0.001) were significantly associated with weight gain pattern with fewer exacerbations occurring amongst those with a decelerated weight gain pattern. We conclude that early life patterns of weight change were associated with subsequent asthma exacerbations, but were not associated with asthma symptoms or pulmonary function during the pre‐school years for these children at‐risk for asthma.

Từ khóa


Tài liệu tham khảo

10.1136/bmj.2.5701.74

10.1136/bmj.320.7240.967

10.1136/bmj.38470.670903.E0

10.1542/peds.109.2.194

10.1038/sj.ijo.0801980

10.1038/oby.2003.62

Mellbin T, 1973, Physical development at 7 years of age in relation to velocity of weight gain in infancy with special reference to incidence of overweight, Br J Prev Soc Med, 27, 225

10.1093/ajcn/77.6.1374

10.1093/ajcn/83.2.324

10.1038/sj.ijo.0802409

10.1038/sj.ijo.0803054

10.1093/ajcn/82.2.456

10.1136/adc.2007.116855

10.1038/oby.2006.64

10.1093/ajcn/87.6.1776

10.1093/ajcn/87.6.1587

10.1161/01.CIR.0000118500.23649.DF

10.1097/00004872-200018070-00002

10.1161/hc0902.104677

10.1046/j.1464-5491.2003.00949.x

10.1136/bmj.318.7181.427

10.1056/NEJMoa044160

10.7326/0003-4819-133-3-200008010-00008

10.1056/NEJMoa035698

10.1016/S0140-6736(89)90710-1

10.1136/bmj.306.6875.422

10.1016/0140-6736(93)91224-A

10.1016/S0022-3476(98)70491-3

10.1016/S0140-6736(04)16210-7

Mannino DM, 2002, Surveillance for asthma‐‐United States, 1980–1999, MMWR Surveill Summ, 51, 1

Tantisira KG, 2001, Complex interactions in complex traits: obesity and asthma, Thorax, 56, 64

10.1056/NEJMra054308

10.1111/j.1399-3038.2008.00812.x

10.1164/ajrccm/142.3.555

Weitzman M, 1990, Racial, social, and environmental risks for childhood asthma, Am J Dis Child, 144, 1189

10.1136/adc.66.5.584

10.1183/09031936.98.12061366

10.1046/j.1365-2222.1998.00282.x

10.1164/ajrccm.160.1.9807104

10.1136/thx.54.5.396

10.1093/eurpub/12.3.166

10.1111/j.1399-3038.1998.tb00308.x

10.1136/thorax.56.11.835

10.1164/ajrccm.163.6.2006140

10.1136/thorax.56.11.845

10.1038/oby.2000.74

10.1136/adc.2005.080390

10.1542/peds.2007-0500

10.1136/thorax.56.2.133

10.1007/s11524-006-9050-9

10.2105/AJPH.94.9.1531

10.1056/NEJMoa051378

2007, National Asthma Education and Prevention Program: Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma

10.1164/ajrccm.162.4.9912111

10.1016/j.cct.2004.03.002

10.1016/j.jaci.2004.09.020

10.1111/j.1471-0528.1987.tb03717.x

10.1093/ije/16.4.550

10.1093/ije/17.3.688

Gayle HD, 1988, Validation of maternally reported birth weights among 46,637 Tennessee WIC program participants, Public Health Rep, 103, 143

10.1177/000992289103000811

10.1093/ije/23.5.1006

10.1001/archpedi.1995.02170180083016

10.2105/AJPH.87.1.114

10.1136/adc.82.3.202

10.1016/S0033-3506(00)00328-0

http://www.cdc.gov/nchs/about/major/nhanes/growthcharts/datafiles.htm.

10.1164/ajrccm.164.12.2101002

10.1016/B978-032304048-8.50016-5

10.1056/NEJMe058187

10.1136/thx.2004.032359

10.1542/peds.2007-0409

10.1164/ajrccm.163.6.2006140

10.1164/rccm.200309-1224OC

10.1016/j.jaci.2008.03.004

10.1093/ajcn/84.6.1449

10.1111/j.1399-3038.2007.00690.x

10.1183/09031936.00066307

Thông tin
Thông tin xuất bản

Pediatric Allergy and Immunology

Tập 21 Số 1-Part-I

82-89

Thông tin tác giả