Relationship between exploratory eye movements and brain morphology in schizophrenia spectrum patients
Tóm tắt
The exploratory eye movements of schizophrenia
patients and their relatives have been shown to
differ from those of patients without schizophrenia and
healthy controls. However the mechanism of exploratory
eye movement disturbances in schizophrenia
patients remains elusive. We investigated the relationship
between the exploratory eye movements and brain
morphology in 39 schizophrenia spectrum patients.
Voxel–based morphometric analysis on three–dimensional
magnetic resonance imaging was conducted by
means of statistical parametric mapping 99. The decrease
in the responsive search score, which is the total
number of sections on which the eyes fixed in response
to questioning in a comparison task, was significantly
correlated with the decreased gray matter in the right
frontal eye field (rFEF) including the right supplementary
eye field (rSEF), right parietal eye field (rPEF), and
right inferior frontal region. These results suggest that
disturbance in exploratory eye movement in schizophrenia
spectrum patients may be related to neural network
dysfunction in FEF, SEF and PEF, which are the eye
movement related areas, and in the inferior frontal region
that may be related to information organization.
Tài liệu tham khảo
Andersen RA, Gnadt JW (1989) Posterior parietal cortex. In: Wurtz H,Goldberg ME (eds) The neurobiology of saccadic eye movements. Elsevier, Amsterdam, pp 315–336
Ashburner J, Friston K (1997) Multimodal image coregistration and partitioning: a unified framework. Neuroimage 6:209–217
Ashburner J, Friston KJ (2000) Voxel-based morphometry – The methods. Neuroimage 11:805–821
Baron M, Risch N (1987) The spectrum concept of schizophrenia: evidence for a genetic-environmental continuum. J Psychiatric Res 21:257–267
Benes FM, NcSparren J, Bird ED, SanGiovanni JP, Vincent SL (1991) Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry 48:996–1001
Buchanan RW, Vladar K, Barta PE, Pearlson GD (1998) Structural evaluation of the prefrontal cortex in schizophrenia. Am J Psychiatry 155:1049–1055
Corbetta M, Akbudak E, Conturo TE, Snyder AZ, Ollinger JM, Drury HA, Linenweber MR, Petersen SE, Raichle ME, Van Essen DC, Shulman GL (1998) A common network of functional areas for attention and eye movements. Neuron 21:761–773
Dickey CC, McCarley RW, Shenton ME (2002) The brain in schizotypal personality disorder: a review of structural MRI and CT findings. Harvard Rev Psychiatry 10:1–15
Diefendorf AR, Dogde R (1908) An experimental study of the ocular reactions of the insane from photographic records. Brain 31:451–489
First MB, Spitzer RL,Williams JBW, Gibson M (1996) Structured Clinical Interview for DSM-IV axis II disorders. New York State Psychiatric Institute, New York
Fletcher PC, Shallice T, Dolan RJ (1998) The functional roles of prefrontal cortex in episodic memory I. Encoding. Brain 121:1239–1248
Friston KJ, Frith CD, Liddle PF, Dolan RJ, Lammertsma AA, Frackowiak, RSJ (1990) The relationship between global and local changes in PET scans. J Cereb Blood Flow Metab 10:458–466
Gaymard B, Ploner CJ, Rivaud S, Vermersch AI, Pierrot-Deseilligny C (1998) Cortical control of saccades. Exp Brain Res 123:159–163
Goldberg ME, Segraves MA (1989) The visual and frontal cortices. In: Wurtz RH,Goldberg ME (eds) The neurobiology of saccadic eye movements. Elsevier, Amsterdam, pp 283–314
Hagino H, Suzuki M, Mori K, Nohara S, Yamashita I, Takahashi T, Kurokawa K, Matsui M, Watanabe N, Seto H, Kurachi M (2002) Proton magnetic resonance spectroscopy of the inferior frontal gyrus and thalamus and its relationship to verbal learning task performance in patients with schizophrenia: a preliminary report. Psychiatry Clin Neurosci 56:499–507
Heide W, Kompf D (1998) Combined deficits of saccades and visuo- spatial orientation after cortical lesions. Exp Brain Res 123:164–171
Holzman PS, Proctor LR, Hughes DW (1973) Eye tracking patterns in schizophrenia. Science 181:179–181
Kendler KS, Masterson CC, Urgaro R, Davis KL (1984) A family history study of schizophrenia-related personality disorders. Am J Psychiatry 141:424–427
Kawasaki Y, Suzuki M, Nohara S, Hagino H, Takahashi T, Matsui M, Yamashita I, Chitnis XA, McGuire PK, Seto H, Kurachi M (2004) Structural brain differences in patients with schizophrenia and schizotypal disorder demonstrated by voxel-based morphometry. Eur Arch Psychiatry Clin Neurosci (in press)
Kendler KS, Neale MC, Walsh D (1995) Evaluating the spectrum concept of schizophrenia in the Roscommon family study. Am J Psychiatry 152:749–754
Kojima T, Matsushima E, Nakajima K, Shiraishi H, Ando K, Ando H, Shimazono Y (1990) Eye movements in acute, chronic and remitted schizophrenics. Biol Psychiatry 27:975–989
Kojima T, Matsushima E, Ando K, Ando H (1992) Exploratory eye movements and neuropsychological tests in schizophrenic patients. Schizophr Bull 18:85–94
Kojima T, Matsushima E, Ando K (eds) (2000) Eyes and the mind. Japan Scientific Societies Press and S Karger, Tokyo Basel
Kojima T, Matsushima E, Ohta K, Toru M (2001) Stability of exploratory eye movements as a marker of schizophrenia – a WHO multi-center study. Schizophr Res 52:203–213
Kurachi M, Matsui M, Kiba K, Suzuki M, Tsunoda M, Yamaguchi N, (1994) Limited visual search on the WAIS picture completion test in patients with schizophrenia. Schizophr Res 12:75–80
Lawrie SM, Abukmeil SS (1998) Brain abnormality in schizophrenia: a systematic and quantitative review of volumetric magnetic resonance imaging studies. Br J Psychiatry 172:110–120
Lawrie SM, Whalley H, Kestelman JN, Abukmeil SS, Byrne M, Hodges A, Rimmington JE, Best JJ, Owens DG, Johnstone EC (1999) Magnetic resonance imaging of brain in people at high risk of developing schizophrenia. Lancet 353:30–33
Lawrie SM, Whalley HC, Abukmeil SS, Kestelman JN, Donnelly L, Miller P, Best JJK, Owens BDGC, Johnstone EC (2001) Brain structure, genetic liability, and psychotic symptoms in subjects at high risk of developing schizophrenia. Biol Psychiatry 49:811–823
Matsushima E, Kojima T, Ohbayashi S, Ando H, Ando K, Shimazono Y (1992) Exploratory eye movements in schizophrenic patients and patients with frontal lobe lesions. Eur Arch Psychiatry Clin Neurosci 241:310–314
Matsushima E, Takebayashi H, Kojima T (1996) Abnormalexploratory eye movements and cognitive mechanism in patients with schizophrenia. Rinsho Noha (Clinical Electroencephalography) 38:291–294 (in Japanese)
Matsushima E, Kojima T, Ohta K, Obayashi S, Nakajima K, Kakuma T, Ando H, Toru M (1998) Exploratory eye movement dysfunctions in patients with schizophrenia: possibility as a discriminator for schizophrenia. J Psychiatr Res 32:289–295
Matsushima E, Kubo H, Kojima T, Ohta K (1999) Exploratory eye movement in patients with schizophrenia – a monozygotic twins study. In: Abstracts II of the XI World Congress of Psychiatry, Hamburg, p 11
Moriya H, Ando K,Kojima T, Shimazono Y, Ogiwara R, Jimbo K, Ushikubo T (1972) Eye movements during perception of pictures I chronic schizophrenia. Folia Psychiat Neurol Jpn 26:189–199
Nohara S, Suzuki M, Kurachi M, Yamashita I, Masui M, Seto H, Saitoh O (2000) Neural correlates of memory organization deficits schizophrenia – A single photon emission computed tomography study with 99m Tc-ECD during a verbal learning task. Schizophr Res 42:209–222
Pierrot-Deseilligny C, Rivaud S, Gaymard B, Muri R, Vermersch AI (1995) Cortical control of saccades. Ann Neurol 37:557–567
Pierrot-Deseilligny C, Gaymard B, Muri R, Rivaud S (1997) Cerebral ocular motor sign. J Neurol 244:65–70
Schlaepfer TE, Harris GJ, Tien AY, Peng LW, Lee S, Federman EB, Chase GA, Barta PE, Pearlson GD (1994) Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry 151:842–848
Seidman LJ, Faraone SV, Goldstein JM, Kremen WS, Horton NJ, Makris N, Toomey R, Kennedy D, Caviness VS, Tsuang MT (2002) Left hippocampal volume as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric study of nonpsychotic first-degree relatives. Arch Gen Psychiatry 59:839–849
Selemon LD, Rajkowska G, Goldman-Rakic PS (1995) Abnormally high neuronal density in the schizophrenic cortex. Arch Gen Psychiatry 52:805–818
Shagass C, Roemer RA, Amadeo M (1976) Eye-tracking performance and engagement of attention. Arch Gen Psychiatry 33:121–125
Shenton ME, Dickey CC, Frumin M, McCarley RW (2001) A review of MRI findings in schizophrenia. Schizophr Res 49:1–52
Siever LJ, Koeningsberg HW, Harvey P, Mitropoulou V, Laruelle M, Abi-Dargham A, Goodman M, Buchsbaum M (2002) Cognitive and brain function in schizotypal personality disorder. Schizophr Res 54:157–167
Suzuki M, Nohara S, Hagino H, Kurokawa K, Yotsutsuji T, Kasasaki Y, Takahashi T, Matsui M, Watanabe N, Seto H, Kurachi M (2002) Regional changes in brain gray and white matter in patients with schizophrenia demonstrated with voxel-based analysis of MRI. Schizophr Res 55:41–54
Takahashi S, Tanabe E, Sakai T, Xia M, Matsuura M, Matsushima E, Obayashi S, Kojima T (1996) Correlation between neurophysiological abnormalities and brain morphological changes in schizophrenia. Rinsho Noha (Clinical Electroencephalography) 38:85–91 (in Japanese)
Takahashi S, Tanabe E, Kojima T, Matsushima E, Yara K (1999) Exploratory eye movement of dysfunction in schizophrenic patients and their siblings. In: Abstracts II of the XI World Congress of Psychiatry, Hamburg, p 15
Takahashi T, Suzuki M, Kawasaki Y, Kurokawa K, Hagino H, Yamashita I, Zhou S-Y, Nohara S, Nakamura K, Seto H, Kurachi M (2002) Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorder. Eur Arch Psychiatry Clin Neurosci 252:268–277
Talairach J, Tournoux P (1998) Co-planar stereotaxic atlas of the human brain. Georg Thieme, Stuttgart-New York
Tonoya Y, Matsui M, Kurachi M, Kurokawa K, Sumiyoshi T (2002) Exploratory eye movements in schizophrenia: effects of figure size and the instruction on visual search. Eur Arch Psychiatry Clin Neurosci 252:255–261
Tsuang MT, Bucher KD, Fleming JA (1983) A search for ‘schizophrenia spectrum disorders’. An application of a multiple threshold model to blind family study data. Br J Psychiatry 143:572–577
Tsunoda M, Kurachi M, Yuasa S, Kadono Y, Matsui M, Shimizu A, (1992) Scanning eye movements in schizophrenic patients: relationship to clinical symptoms and regional cerebral blood flow using 123I-IMP SPECT. Schizophr Res 7:159–168
Van Erp TG, Saleh PA, Rosso IM, Huttunen M, Lonnqvist J, Pirkola T, Salonen O, Valanne L, Poutanen VP, Standerskjold- Nordenstam CG, Cannon TD (2002) Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers. Am J Psychiatry 159:1514–1520
Wing JK, Cooper JE, Sartorius N (1974) Measurement and classification of psychiatric symptoms.An introduction manual for the PSE and CATEGO program. Cambridge University Press, London
World Health Organization (1993) The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. World Health Organization, Geneva
Wright IC, Ellison ZR, Sharma T, Friston KJ, Murray RM, McGuire PK (1999) Mapping of grey matter changes in schizophrenia. Schizophr Res 35:1–14
Wright IC, Rabe-Hesketh S, Woodruff PWR, David AS, Murray RM, Bullmore ET (2000) Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry 157:16–25
Xia ML, Takahashi S, Tanabe E, Matsushima M, Kojima T, Matsushima E (1996) Eye movement studies on schizophrenics and their parents. Eur Neuropsychopharm 6(Suppl 3):64
Yoneyama E, Matsui M, Kawasaki Y, Nohara S, Takahashi T, Hagino H, Suzuki M, Seto H, Kurachi M (2003) Gray matter features of schizotypal disorder patients exhibiting the schizophrenia- related code types of the Minnesota Multiphasic Personality Inventory. Acta Psychiatr Scand 108:333–340
Zipursky RB, Lim KO, Sullivan EV, Brown BW, Pfefferbaum A (1992) Widespread cerebral gray matter volume deficits in schizophrenia. Arch Gen Psychiatry 49:195–205