Relación del factor de crecimiento de fibroblastos 21 con indicadores de masa y función muscular en personas mayores con sobrepeso u obesidad. Estudio exploratorio

Anton, 2013, Obesity and diabetes as accelerators of functional decline: Can lifestyle interventions maintain functional status in high risk older adults?, Exp Gerontol., 48, 888, 10.1016/j.exger.2013.06.007 Cruz-Jentoft, 2019, Sarcopenia: Revised European consensus on definition and diagnosis, Age Ageing., 48, 16, 10.1093/ageing/afy169 Bautmans, 2009, Sarcopenia and functional decline: Pathophysiology, prevention and therapy, Acta Clin Belg., 64, 303, 10.1179/acb.2009.048 Moon, 2015, Relationship between low muscle mass and metabolic syndrome in elderly people with normal body mass index, J Bone Metab., 22, 99, 10.11005/jbm.2015.22.3.99 Rubio-Ruiz, 2019, Mechanisms underlying metabolic syndrome-related sarcopenia and possible therapeutic measures, Int J Mol Sci., 20, 647, 10.3390/ijms20030647 Cleasby, 2016, Insulin resistance and sarcopenia: mechanistic links between common co-morbidities, J Endocrinol., 229, R67, 10.1530/JOE-15-0533 Barbat-Artigas, 2012, Muscle quality as a potential explanation of the metabolically healthy but obese and sarcopenic obese paradoxes, Metab Syndr Relat Disord., 10, 117, 10.1089/met.2011.0092 Oh, 2017, Metabolic adaptation in obesity and type II diabetes: Myokines, adipokines and hepatokines, Int J Mol Sci., 18, 8, 10.3390/ijms18010008 Pedersen, 2009, The diseasome of physical inactivity—and the role of myokines in muscle—fat cross talk, J Physiol., 587, 5559, 10.1113/jphysiol.2009.179515 Kharitonenkov, 2014, Inventing new medicines: The FGF21 story, Mol Metab., 3, 221, 10.1016/j.molmet.2013.12.003 Fisher, 2016, Understanding the Physiology of FGF21, Annu Rev Physiol., 78, 223, 10.1146/annurev-physiol-021115-105339 Mashili, 2011, Direct effects of FGF21 on glucose uptake in human skeletal muscle: Implications for type2 diabetes and obesity, Diabetes Metab Res Rev., 27, 286, 10.1002/dmrr.1177 Oost, 2019, Fibroblast growth factor 21 controls mitophagy and muscle mass, J Cachexia Sarcopenia Muscle., 10, 630, 10.1002/jcsm.12409 Fisher, 2010, Obesity is a fibroblast growth factor21 (FGF21)-resistant state, Diabetes., 59, 2781, 10.2337/db10-0193 Barb, 2019, Plasma fibroblast growth factor21 is associated with severity of nonalcoholic steatohepatitis in patients with obesity and type2 diabetes, J Clin Endocrinol Metab., 104, 3327, 10.1210/jc.2018-02414 Hanks, 2015, Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals, J Clin Transl Endocrinol., 2, 77 Barzilai, 2012, The critical role of metabolic pathways in aging, Diabetes., 61, 1315, 10.2337/db11-1300 Gobierno de Chile, Ministerio de Salud. Manual de Aplicación del Examen de Medicina Preventiva del Adulto Mayor 2010. Disponible en: https://www.minsal.cl/portal/url/item/ab1f81f43ef0c2a6e04001011e011907.pdf Wang, 2013, Comparison of two bioelectrical impedance analysis devices with dual energy X-ray absorptiometry and magnetic resonance imaging in the estimation of body composition, J Strength Cond Res., 27, 236, 10.1519/JSC.0b013e31824f2040 Lera, 2014, Anthropometric model for the prediction of appendicular skeletal muscle mass in Chilean older adults, Nutr Hosp., 29, 611 Melo, 2019, The Five Times Sit-to-Stand Test: Safety and reliability with older intensive care unit patients at discharge, Rev Bras Ter Intensiva., 31, 27, 10.5935/0103-507X.20190006 Gale, 2007, Grip strength, body composition, and mortality, Int J Epidemiol., 36, 228, 10.1093/ije/dyl224 Organización Mundial de la Salud. Recomendaciones mundiales sobre la actividad física para la salud: OMS; 2020 [consultado 8 Oct 2020]. Disponible en: https://www.who.int/dietphysicalactivity/factsheet_recommendations/es/ Garmendia, 2009, Valores normativos de resistencia a la insulina mediante HOMA-IR en adultos mayores de Santiago de Chile, Rev Med Chile., 137, 1409, 10.4067/S0034-98872009001100001 Mankowski, 2015, The role of muscle mass muscle quality, and body composition in risk for the metabolic syndrome and functional decline in older adults, Curr Geriatr Rep., 4, 221, 10.1007/s13670-015-0132-y Barbat-Artigas, 2014, Exploring the role of muscle mass, obesity, and age in the relationship between muscle quality and physical function, J Am Med Dir Assoc., 15, 10.1016/j.jamda.2013.12.008 Stenholm, 2008, Sarcopenic obesity: Definition, cause and consequences, Curr Opin Clin Nutr Metab Care., 11, 693, 10.1097/MCO.0b013e328312c37d Hayashida, 2014, Correlation between muscle strength and muscle mass, and their association with walking speed, in community-dwelling elderly Japanese individuals, PLoS One., 9, e111810, 10.1371/journal.pone.0111810 Delmonico, 2009, Longitudinal study of muscle strength, quality, and adipose tissue infiltration, Am J Clin Nutr., 90, 1579, 10.3945/ajcn.2009.28047 Distefano, 2018, Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults, J Cachexia Sarcopenia Muscle., 9, 279, 10.1002/jcsm.12272 Shou, 2020, Mechanism of increased risk of insulin resistance in aging skeletal muscle, Diabetol Metab Syndr., 12, 14, 10.1186/s13098-020-0523-x Opoku, 2019, Therapeutic role of fibroblast growth factor21 (FGF21) in the amelioration of chronic diseases, Int J Pept Res Ther., 26, 107, 10.1007/s10989-019-09820-8 Kim, 2019, Deficiency of fibroblast growth factor21 aggravates obesity-induced atrophic responses in skeletal muscle, J Inflamm (Lond)., 16, 17, 10.1186/s12950-019-0221-3 Tezze, 2019, FGF21 as modulator of metabolism in health and disease, Front Physiol., 10, 419, 10.3389/fphys.2019.00419