Regulatory requirements of bioactive peptides (protein hydrolysates) from food proteins

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Carrillo, 2016, Identification of antioxidant peptides of hen egg–white lysozyme and evaluation of inhibition of lipid peroxidation and cytotoxicity in the Zebrafish model, European Food Research and Technology, 242, 1777, 10.1007/s00217-016-2677-1

Chalamaiah, 2012, Fish protein hydrolysates: Proximate composition, amino acid composition, antioxidant activities and applications: A review, Food Chemistry, 135, 3020, 10.1016/j.foodchem.2012.06.100

Chalamaiah, 2017, Anti-inflammatory capacity of hen egg yolk livetins fraction (α, β & γ livetins) and its enzymatic hydrolysates in lipo-polysaccharide (LPS) induced RAW 264.7 macrophages, Food Research International, 100, 449, 10.1016/j.foodres.2017.07.032

Chalamaiah, 2018, Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: A review, Food Chemistry, 245, 205, 10.1016/j.foodchem.2017.10.087

Daliri, 2017, Bioactive peptides, Foods, 6, 32, 10.3390/foods6050032

Dullius, 2018, Whey protein hydrolysates as a source of bioactive peptides for functional foods – Biotechnological facilitation of industrial scale-up, Journal of Functional Foods, 42, 58, 10.1016/j.jff.2017.12.063

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EFSA Panel (EC) No 1924/2006 (on Dietetic Products, Nutrition and Allergies), 2010, Scientific opinion on the substantiation of health claims related to bonito protein peptide and maintenance of normal blood pressure (ID 1716) pursuant to Article 13(1) of Regulation (EC) No 1924/2006, EFSA Journal, 8, 1730, 10.2903/j.efsa.2010.1730

Gevaert, 2016, Fish hydrolysates: A regulatory perspective of bioactive peptides, Protein & Peptide Letters, 23, 1, 10.2174/0929866523666161102122637

He, 2015, Enzymatic hydrolysis optimization of Paphia undulata and lymphocyte proliferation activity of the isolated peptide fractions, Journal of the Science of Food and Agriculture, 95, 1544, 10.1002/jsfa.6859

Hou, 2016, Immunomodulatory activity of Alaska pollock hydrolysates obtained by glutamic acid biosensor – Artificial neural network and the identification of its active central fragment, Journal of Functional Foods, 24, 37, 10.1016/j.jff.2016.03.033

Huang, 2012, Sepia ink oligopeptide induces apoptosis in prostate cancer cell lines via caspase-3 activation and elevation of Bax/Bcl-2 ratio, Marine Drugs, 10, 2153, 10.3390/md10102153

Lafarga, 2017, Bioactive protein hydrolysates in the functional food ingredient industry: Overcoming current challenges, Food Reviews International, 33, 217, 10.1080/87559129.2016.1175013

Lammi, 2015, Two peptides from soy β–conglycinin induce a hypocholesterolemic effect in HepG2 Cells by a statin-like mechanism: comparative in vitro and in silico modeling studies, Journal of Agricultural and Food Chemistry, 63, 7945, 10.1021/acs.jafc.5b03497

Lee, 2010, A novel angiotensin I converting enzyme inhibitory peptide from tuna frame protein hydrolysate and its antihypertensive effect in spontaneously hypertensive rats, Food Chemistry, 118, 96, 10.1016/j.foodchem.2009.04.086

Liang, 2018, Identification of new anti-inflammatory peptides from zein hydrolysate after simulated gastrointestinal digestion and transport in Caco–2 Cells, Journal of Agriculture and Food Chemistry, 66, 1114, 10.1021/acs.jafc.7b04562

Li-Chan, 2015, Bioactive peptides and protein hydrolysates: Research trends and challenges for application as nutraceuticals and functional food ingredients, Current Opinion in Food Science, 1, 28, 10.1016/j.cofs.2014.09.005

Lin, 2017, Purification and identification of hypocholesterolemic peptides from freshwater clam hydrolysate with in vitro gastrointestinal digestion, Journal of Food Biochemsitry, 41

Majumder, 2013, Egg-derived tri-Peptide IRW exerts antihypertensive effects in spontaneously hypertensive rats, PLoS One, 8, 10.1371/journal.pone.0082829

Majumder, 2015, Egg-derived ACE-inhibitory peptides IQW and LKP reduce blood pressure in spontaneously hypertensive rats, Journal of Functional Foods, 13, 50, 10.1016/j.jff.2014.12.028

Nimalaratne, 2015, Purification and characterization of antioxidant peptides from enzymatically hydrolyzed chicken egg white, Food Chemistry, 188, 467, 10.1016/j.foodchem.2015.05.014

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Rizzello, 2016, Bioactive peptides from vegetable food matrices: research trends and novel biotechnologies for synthesis and recovery, Journal of Functional Foods, 27, 549, 10.1016/j.jff.2016.09.023

Shi, 2018, Identification and mechanism of peptides with activity promoting osteoblast proliferation from bovine lactoferrin, Food Bioscience, 22, 19, 10.1016/j.fbio.2017.12.011

Subhadeep, 2018, Food-derived bioactive peptides in human health: Challenges and opportunities, Nutrients, 10, 1738, 10.3390/nu10111738

Takahashi, 1994, Isolation and characterization of oryzatensin: A novel bioactive peptide with ileumcontracting and immunomodulating activities derived from rice albumin, Biochemistry and Molecular Biology International, 33, 1151

Shimizu, 2002, Newly established regulation in Japan: Foods with health claims, Asia Pacific Journal of Clinical Nutrition, 11, S94, 10.1046/j.1440-6047.2002.00007.x

Tsuruki, 2003, Soymetide, an immunostimulating peptide derived from soybean L-conglycinin, is an fMLP agonist, FEBS Letters, 540, 206, 10.1016/S0014-5793(03)00265-5

Vital, 2014, Peptides in common bean fractions inhibit human colorectal cancer cells, Food Chemistry, 157, 347, 10.1016/j.foodchem.2014.02.050

Xue, 2018, Identification and characterization of an angiotensin-converting enzyme inhibitory peptide derived from bovine casein, Peptides, 99, 161, 10.1016/j.peptides.2017.09.021

Zambrowicz, 2015, Antioxidant and antidiabetic activities of peptides isolated from a hydrolysate of an egg-yolk protein by-product prepared with a proteinase from Asian pumpkin (Cucurbita ficifolia), RSC Advances, 5, 10460, 10.1039/C4RA12943A

Zhang, 2015, Peptides derived from oats improve insulin sensitivity and lower blood glucose in streptozotocin-induced diabetic mice, Journal of Biomedical Science, 4, 1

Zhang, 2010, Isolation and identification of antioxidative peptide from rice endosperm protein enzymatic hydrolysate by consecutive chromatography and MALDI-TOF/TOF MS/MS, Food Chemistry, 119, 226, 10.1016/j.foodchem.2009.06.015