Regulatory T cells in inflammation and resolution of acute lung injury

Clinical Respiratory Journal - Tập 16 Số 9 - Trang 587-595 - 2022
Linlin Wang1, Weipeng Jiang1, Xiaocen Wang1, Lin Tong1, Yuanlin Song1,2,3,4,5,6
1Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
2Jinshan Hospital of Fudan University, Shanghai, China
3National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China
4Shanghai Institute of Infectious Disease and Biosecurity, Shanghai, China
5Shanghai Key Laboratory of Lung Inflammation and Injury, Department of Pulmonary Medicine, Zhongshan Hospital Fudan University Shanghai China
6Shanghai Respiratory Research Institute, Shanghai, China

Tóm tắt

AbstractIntroductionAcute respiratory distress syndrome (ARDS) is characterized by hypoxemia and increased lung permeability and would result in acute respiratory failure and with high mortality. In patients who survive from acute lung injury (ALI)/ARDS, it is an active process of the transition from injury to resolution depending on the coordinated immune system. The roles of regulatory CD4+T cells (Tregs) are now gradually being clarified during inflammation and resolution of ARDS. However, clear conclusions about roles of Tregs in ALI/ARDS are only a few.ObjectiveThis review provides an overview of phenotype, differentiation, and suppressive mechanisms of Tregs and focuses on keys of biology of Tregs in alveolar space during the inflammatory response and resolution of ALI/ARDS.Data SourceLiterature search of Web of Science, PubMed, and EMBASE was made to find relative articles about Tregs in ALI/ARDS. We used the following search terms: Tregs, ALI, ARDS, inflammation, and resolution.ConclusionMore and more studies have indicated Tregs involved in the processes of inflammation and resolution of ALI/ARDS. A deep understanding of the roles of Tregs may indicate new treatments for patients of ARDS. Therapies aimed at expansion or adaptive transfer of Tregs could be an effective therapy to ARDS patients.

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Thông tin xuất bản

Clinical Respiratory Journal

Tập 16 Số 9

587-595

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